JP2509591B2 - Automatic chemical analyzer - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION Object of the Invention (Industrial field of application) The present invention relates to an automatic chemical analyzer for chemical analysis of a desired item by measuring the absorbance of a mixed solution of a sample and a reagent.

(Prior Art) By using this as a sample for human serum and reacting it with various reagents and measuring the absorbance of this mixed solution, chemical analysis of various items such as protein and cholesterol levels is performed for diagnosis. An automatic chemical analysis device adapted to be used is known. FIG. 2 shows a conventional automatic chemical analyzer, which comprises a plurality of reaction tubes arranged in a constant temperature bath 1.
2a, 2b, 2c, ... Are rotated by a drive mechanism (not shown), for example, in the direction of the arrow to move. A washing mechanism 3, a sample dispensing mechanism 4, and a reagent dispensing mechanism 5 are arranged around the constant temperature bath 1. The sample dispensing mechanism 4 is provided with a sample tray 4a in which a plurality of types of samples 4aa, 4ab, 4ac, ... Are dispensed. The sample pipetting mechanism 4 swings and moves to a position opposite to the sample tray 4a, such as a reaction tube 2a.
To serve to dispense the desired sample. The reagent dispensing mechanism 5 is provided with a reagent tray 5a, which has a plurality of types of reagents.
5aa, 5ab, 5ac,… have been dispensed. The reagent dispensing mechanism 5 works to dispense a desired sample to the reaction tube, for example, 2 g, which has moved to a position facing the reagent tray 5a by swinging.

In this way, the reaction tube 2 that has moved via the sample dispensing mechanism 4 and the reagent dispensing mechanism 5 is mixed with an arbitrary sample and reagent, and the measurement mechanism 6 provided in the middle of the moving path of the reaction tube. When moved to the position of, the absorbance of the mixed solution is measured by this. Therefore, the chemical analysis of the desired item is performed. The reaction tube after the measurement of the absorbance is washed by the washing mechanism 3 to prepare for the next measurement. The operation timing of the constant temperature bath 1, the sample dispensing mechanism 4, the reagent dispensing mechanism 5, etc. is controlled by the controller 7.

(Problems to be Solved by the Invention) In such an automatic chemical analyzer, the reaction tube after the measurement of a certain item is washed and then used again for the measurement of the next item, and such a cycle is repeated. returned. For example, each reaction tube is provided with a program of measurement items as shown in FIG. 3 and sequentially provided for measurement.

By the way, when the reaction tube after the measurement is washed, there is a case in which a small amount is left as it is without being sufficiently removed depending on the reagent used.

Therefore, depending on the reagent used for measuring the next item, there is a problem that the reagent reacts with the remaining reagent and a measurement error occurs.

The present invention has been made in consideration of the above problems, and an object of the present invention is to provide an automatic chemical analyzer that eliminates measurement errors.

[Structure of the Invention] (Means for Solving Problems) In order to achieve the above object, the present invention comprises a plurality of reaction tubes, and a sample and a reagent are mixed in the reaction tubes, and the absorbance of the mixed solution is measured. In the automatic chemical analysis device for performing the chemical analysis of the desired item by doing so, the first storage means for recording the item measured in each of the reaction tubes in association with the reaction tube, and the first storage means for recording the combination of the undesired items Two
Of the storage means and the reaction tube in which the next desired item is to be measured, the previous measurement item information is read from the first storage means, the combination information is read from the second storage means, and both pieces of information are referred to. The control means for determining whether or not the desired item and the read measurement item are a desirable combination is provided.

(Operation) With respect to the reaction tube for measuring the next item, the combination information of the undesired items is read from the second memory together with the measurement item information so far from the first memory and provided for reference. As a result, when it is determined that the execution of the measurement item is not desired, this measurement is avoided.

(Embodiment) FIG. 1 is a layout drawing showing an embodiment of the automatic chemical analyzer of the present invention. Reference numeral 11 is a thermostatic chamber so that a plurality of reaction tubes 12a, 12b, 12c ,. Held in.
13 is a cleaning mechanism, 14 is a sample dispensing mechanism, and a sample tray
14a, which includes multiple samples 14aa, 14ab, 14a
c,… are dispensed. 15 is a reagent dispensing mechanism and is a reagent tray
It is equipped with 15a, which contains multiple reagents 15aa, 15ab, 15ac,…
Is being dispensed. The sample dispensing mechanism 14 and the reagent dispensing mechanism 15 work so as to dispense a desired sample and reagent to the reaction tubes that have moved to the opposite positions. Multiple reagents
Each of the symbols 15aa, 15ab, 15ac, ... 16 is a measuring mechanism and a reaction tube 12
The measurement is performed on the absorbance of the mixed liquid of the sample and the reagent in the reaction tube, which is provided in the middle of the movement path of the sample and has moved to the opposite position.

18 is all reaction tubes 12a, 12b, 12c, used in the reaction tube memory,
Record all items measured in. As an example, 1st time, 2
The contents recorded for each reaction tube are shown for the measurement items performed the second time. An interference item memory 19 records a combination of undesirable items among the measurement items performed in each reaction tube. As an example, the content is classified into an interference item and an interfered item, and a content in which the combination of both is not desirable is shown.

This undesired combination of items means that the reagent used for the interference item for a certain reaction tube is assumed to remain after the cleaning process, and it is not possible to measure the interfered item next with this reaction tube. It is meant that undesired reactions occur with the reagents used therein.

Reference numeral 17 is a control unit which controls the operation timing of the constant temperature chamber 11, the sample dispensing mechanism 14, the reagent dispensing mechanism 15, etc., and also inputs for inputting necessary data to the reaction tube memory 18 and the interference item memory 19. It has a function. Therefore, by operating the control unit 17, it is possible to arbitrarily add or cancel necessary items.

 Next, the operation of this embodiment will be described.

As an example, if you try to measure LDH for the reaction tube 12a as the third item of the reaction tube 12a,
The control unit 17 reads from the reaction tube memory 18 the items for which measurement has already been completed. As a result, the previous item is GPT,
It turns out that the item two times before is LDH. Then control unit 1
7 is a third measurement item LD that reads out a combination of an unwanted interference item and an interfered item from the interference item memory 19.
It is judged whether or not the combination of H and the item samples GPT and LDH before and after once is a desirable combination. As a result, since the sample GPT is recorded in the interference item of the interference item memory 19 and the undesirable combination of LDH is recorded in the interfered item, the control unit 17 determines that the combination is not desirable, and the third LDH is performed.
The control operation is performed so as to avoid the measurement of. With it 3
As a second item, measurement other than LDH is performed, or control operation is performed so that measurement by the reaction tube 12a is not performed.

According to the present embodiment as described above, measurement of an undesired combination of items using the same reaction tube is avoided, so that no measurement error occurs.

In the present embodiment, the case where a specific reaction tube is used to measure a specific item has been described as an example, but it is obvious that the present invention is not limited to these cases.

[Effects of the Invention] As described above, according to the present invention, the reagent used for measuring the following items reacts with the reagent used in the previous measurement remaining in the reaction tube to cause a measurement error. It never happens.

[Brief description of drawings]

FIG. 1 is a layout view showing an automatic chemical analyzer according to an embodiment of the present invention, FIG. 2 is a layout view showing a conventional example, and FIG. 3 is a program used in the conventional example. 12, 12a to 12g ... Reaction tube, 13 ... Washing mechanism, 14 ... Sample dispensing mechanism, 15 ... Reagent dispensing mechanism, 15aa to 15ag ...
… Reagent, 17 …… Control unit, 18 …… Reaction tube memory, 19 …… Interference item memory.

Claims (1)

(57) [Claims] 1. An automatic chemical analyzer comprising a plurality of reaction tubes, wherein a sample and a reagent are mixed in the reaction tubes, and the absorbance of the mixed solution is measured to carry out a chemical analysis of a desired item. The first storage means for recording the item measured in 1. in correspondence with the reaction tube, the second storage means for recording the combination of the undesired items, and the reaction tube for performing the measurement of the next desired item. 1
It is determined whether the desired item and the read measurement item are a desirable combination by reading the measurement item information up to this point from the storage unit, reading the combination information from the second storage unit, and referring to both information. And a control means for controlling the automatic chemical analysis device.