JP2025517965A - Ｓｃａｐ発現を阻害するためのｒｎａｉコンストラクト及びその使用方法 - Google Patents

Ｓｃａｐ発現を阻害するためのｒｎａｉコンストラクト及びその使用方法 Download PDF

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JP2025517965A
JP2025517965A JP2024569102A JP2024569102A JP2025517965A JP 2025517965 A JP2025517965 A JP 2025517965A JP 2024569102 A JP2024569102 A JP 2024569102A JP 2024569102 A JP2024569102 A JP 2024569102A JP 2025517965 A JP2025517965 A JP 2025517965A
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rnai construct
scap
nucleotides
rnai
expression
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JP2025517965A5 (enExample
Inventor
ブラッドリー ジェイ． ハーバリック，
アムリタ ダス，
オリバー ホーマン，
ダニエル シー． エイチ． リン，
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Amgen Inc
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Amgen Inc
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Publication of JP2025517965A5 publication Critical patent/JP2025517965A5/ja
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/35—Nature of the modification
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024569102A 2022-05-25 2023-05-24 Ｓｃａｐ発現を阻害するためのｒｎａｉコンストラクト及びその使用方法 Pending JP2025517965A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263345513P 2022-05-25 2022-05-25
US63/345,513 2022-05-25
PCT/US2023/067384 WO2023230495A2 (en) 2022-05-25 2023-05-24 Rnai constructs for inhibiting scap expression and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2025517965A true JP2025517965A (ja) 2025-06-12
JP2025517965A5 JP2025517965A5 (enExample) 2026-05-20

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JP2024569102A Pending JP2025517965A (ja) 2022-05-25 2023-05-24 Ｓｃａｐ発現を阻害するためのｒｎａｉコンストラクト及びその使用方法

Country Status (14)

Country Link
US (1) US20250313834A1 (enExample)
EP (1) EP4531871A2 (enExample)
JP (1) JP2025517965A (enExample)
KR (1) KR20250017218A (enExample)
CN (1) CN119300841A (enExample)
AR (1) AR129463A1 (enExample)
AU (1) AU2023277621A1 (enExample)
CA (1) CA3257118A1 (enExample)
CL (1) CL2024003564A1 (enExample)
IL (1) IL316643A (enExample)
MX (1) MX2024014428A (enExample)
TW (1) TW202413642A (enExample)
UY (1) UY40288A (enExample)
WO (1) WO2023230495A2 (enExample)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2120580B1 (en) * 2007-02-02 2017-12-27 Baylor College Of Medicine Compositions and methods for the treatment of metabolic disorders
SG11202113112WA (en) * 2019-05-30 2021-12-30 Amgen Inc Rnai constructs for inhibiting scap expression and methods of use thereof

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Publication number Publication date
TW202413642A (zh) 2024-04-01
UY40288A (es) 2024-08-30
WO2023230495A3 (en) 2024-01-04
AR129463A1 (es) 2024-08-28
AU2023277621A1 (en) 2024-11-14
KR20250017218A (ko) 2025-02-04
WO2023230495A2 (en) 2023-11-30
CL2024003564A1 (es) 2025-03-14
MX2024014428A (es) 2024-12-06
IL316643A (en) 2024-12-01
EP4531871A2 (en) 2025-04-09
CA3257118A1 (en) 2023-11-30
CN119300841A (zh) 2025-01-10
US20250313834A1 (en) 2025-10-09

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