JP2025514802A - リンコサミドおよびその使用 - Google Patents

リンコサミドおよびその使用 Download PDF

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Publication number
JP2025514802A
JP2025514802A JP2024562083A JP2024562083A JP2025514802A JP 2025514802 A JP2025514802 A JP 2025514802A JP 2024562083 A JP2024562083 A JP 2024562083A JP 2024562083 A JP2024562083 A JP 2024562083A JP 2025514802 A JP2025514802 A JP 2025514802A
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JP
Japan
Prior art keywords
substituted
pharma
unsubstituted
acceptable salt
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024562083A
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English (en)
Japanese (ja)
Other versions
JP2025514802A5 (enExample
Inventor
マイアーズ，アンドリュー，ジー．
ウー，ケルビン
カルフーン トレスコ，ベン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard University
Original Assignee
Harvard University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard University filed Critical Harvard University
Publication of JP2025514802A publication Critical patent/JP2025514802A/ja
Publication of JP2025514802A5 publication Critical patent/JP2025514802A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2024562083A 2022-04-20 2023-04-19 リンコサミドおよびその使用 Pending JP2025514802A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263332993P 2022-04-20 2022-04-20
US63/332,993 2022-04-20
PCT/US2023/019059 WO2023205206A1 (en) 2022-04-20 2023-04-19 Lincosamides and uses thereof

Publications (2)

Publication Number Publication Date
JP2025514802A true JP2025514802A (ja) 2025-05-09
JP2025514802A5 JP2025514802A5 (enExample) 2026-05-01

Family

ID=88420515

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024562083A Pending JP2025514802A (ja) 2022-04-20 2023-04-19 リンコサミドおよびその使用

Country Status (8)

Country Link
US (1) US20250270246A1 (enExample)
EP (1) EP4511043A4 (enExample)
JP (1) JP2025514802A (enExample)
KR (1) KR20250006139A (enExample)
CN (1) CN119403559A (enExample)
AU (1) AU2023255378A1 (enExample)
CA (1) CA3249734A1 (enExample)
WO (1) WO2023205206A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2026025019A1 (en) 2024-07-26 2026-01-29 President And Fellows Of Harvard College Synthesis of macrobicyclic thiolincosamines
WO2026043875A1 (en) 2024-08-20 2026-02-26 President And Fellows Of Harvard College Synthesis of oxepanoprolines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
CZ307305B6 (cs) * 2017-03-10 2018-05-23 Mikrobiologický ústav AV ČR, v. v. i. Linkosamidy, jejich příprava a použití
US20230203081A1 (en) * 2020-05-22 2023-06-29 President And Fellows Of Harvard College Lincosamide antibiotics and uses thereof

Also Published As

Publication number Publication date
CN119403559A (zh) 2025-02-07
US20250270246A1 (en) 2025-08-28
WO2023205206A1 (en) 2023-10-26
AU2023255378A1 (en) 2024-11-07
EP4511043A1 (en) 2025-02-26
CA3249734A1 (en) 2023-10-26
KR20250006139A (ko) 2025-01-10
EP4511043A4 (en) 2026-06-10

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Effective date: 20260420

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