JP2025514751A - 遺伝子発現のサプレッサー及び／または合成経路活性化因子及び／または誘導性ペイロードを含む細胞 - Google Patents

遺伝子発現のサプレッサー及び／または合成経路活性化因子及び／または誘導性ペイロードを含む細胞 Download PDF

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JP2025514751A
JP2025514751A JP2024561779A JP2024561779A JP2025514751A JP 2025514751 A JP2025514751 A JP 2025514751A JP 2024561779 A JP2024561779 A JP 2024561779A JP 2024561779 A JP2024561779 A JP 2024561779A JP 2025514751 A JP2025514751 A JP 2025514751A
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receptor
nucleic acid
cells
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seq
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JPWO2023205724A5 (https=
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アーロン クーパー
ジョセフ チェ
パナヨトプル ソフィア キリアゾプル
マリアン サンドバル
ギャヴィン シェイヴィー
スティーブン サントロ
ルーク カッセロー
ブライアン スー
ジェイソン ホール
ナタリー ベズマン
トーマス ガードナー
アンジ ヤオ
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アーセナル バイオサイエンシズ インコーポレイテッド
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/41—Vertebrate antigens
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
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JP2024561779A 2022-04-20 2023-04-20 遺伝子発現のサプレッサー及び／または合成経路活性化因子及び／または誘導性ペイロードを含む細胞 Pending JP2025514751A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202263333076P 2022-04-20 2022-04-20
US63/333,076 2022-04-20
US202263369656P 2022-07-27 2022-07-27
US63/369,656 2022-07-27
US202263376499P 2022-09-21 2022-09-21
US202263376531P 2022-09-21 2022-09-21
US63/376,499 2022-09-21
US63/376,531 2022-09-21
US202263384600P 2022-11-21 2022-11-21
US63/384,600 2022-11-21
PCT/US2023/065998 WO2023205724A2 (en) 2022-04-20 2023-04-20 Cells comprising a suppressor of gene expression and/or a synthetic pathway activator and/or an inducible payload

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JP2025514751A true JP2025514751A (ja) 2025-05-09
JPWO2023205724A5 JPWO2023205724A5 (https=) 2026-04-21
JP2025514751A5 JP2025514751A5 (https=) 2026-04-21

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JP2024561779A Pending JP2025514751A (ja) 2022-04-20 2023-04-20 遺伝子発現のサプレッサー及び／または合成経路活性化因子及び／または誘導性ペイロードを含む細胞

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US (1) US20250049854A1 (https=)
EP (1) EP4496806A2 (https=)
JP (1) JP2025514751A (https=)
CN (1) CN119156398A (https=)
AU (1) AU2023256671A1 (https=)
CA (1) CA3248111A1 (https=)
MX (1) MX2024012971A (https=)
WO (1) WO2023205724A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20252678A1 (es) * 2023-03-13 2025-11-24 Arsenal Biosciences Inc Activadores de vias sinteticas
AU2024340744A1 (en) * 2023-09-14 2026-04-16 Outpace Bio, Inc. Anti-mesothelin chimeric antigen receptors and methods of use
WO2025085846A1 (en) * 2023-10-20 2025-04-24 A2 Biotherapeutics, Inc. Engineered interleukins and uses thereof
CN121449751A (zh) * 2024-07-31 2026-02-03 浙江瑞加美生物科技有限公司 一种功能增强的通用型双靶点BCMA/CD19-mbIL15-CAR-DNT细胞的构建、制备与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3095757A1 (en) * 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
WO2021096783A1 (en) * 2019-11-07 2021-05-20 The Regents Of The University Of California Use of mog for priming a treatment for glioblastoma
AU2021334366A1 (en) * 2020-08-28 2023-05-11 Arsenal Biosciences, Inc. Engineered immune cells with priming receptors
AU2022366987A1 (en) * 2021-10-14 2024-05-16 Arsenal Biosciences, Inc. Immune cells having co-expressed shrnas and logic gate systems

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US20250049854A1 (en) 2025-02-13
CA3248111A1 (en) 2023-10-26
WO2023205724A2 (en) 2023-10-26
CN119156398A (zh) 2024-12-17
WO2023205724A3 (en) 2023-11-30
AU2023256671A1 (en) 2024-12-05
MX2024012971A (es) 2025-02-10
EP4496806A2 (en) 2025-01-29

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