JP2025512680A - 細胞培養の制御のためのハイブリッド予測モデル化 - Google Patents

細胞培養の制御のためのハイブリッド予測モデル化 Download PDF

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JP2025512680A
JP2025512680A JP2024550827A JP2024550827A JP2025512680A JP 2025512680 A JP2025512680 A JP 2025512680A JP 2024550827 A JP2024550827 A JP 2024550827A JP 2024550827 A JP2024550827 A JP 2024550827A JP 2025512680 A JP2025512680 A JP 2025512680A
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cell culture
attributes
values
model
control
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ラシェディ，モハマド
コダバンデル，ハミド
ラフィエシシャバン，セイデミナ
デマーズ，マシュー・エヌ
トゥルシャン，アディティア
ワン，トニー・ワイ
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アムジエン・インコーポレーテツド
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
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    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
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    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G06N20/10—Machine learning using kernel methods, e.g. support vector machines [SVM]
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    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/04—Architecture, e.g. interconnection topology
    • G06N3/0464—Convolutional networks [CNN, ConvNet]
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    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/084—Backpropagation, e.g. using gradient descent
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    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00—Computing arrangements based on biological models
    • G06N3/02—Neural networks
    • G06N3/08—Learning methods
    • G06N3/09—Supervised learning

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JP2024550827A 2022-03-01 2023-02-24 細胞培養の制御のためのハイブリッド予測モデル化 Pending JP2025512680A (ja)

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US202263315358P 2022-03-01 2022-03-01
US63/315,358 2022-03-01
PCT/US2023/013763 WO2023167802A1 (en) 2022-03-01 2023-02-24 Hybrid predictive modeling for control of cell culture

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JP2025512680A5 JP2025512680A5 (https=) 2026-03-18

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US (1) US12590283B2 (https=)
EP (1) EP4482938A1 (https=)
JP (1) JP2025512680A (https=)
KR (1) KR20240158250A (https=)
CN (1) CN118829718A (https=)
AR (1) AR128639A1 (https=)
AU (1) AU2023228806A1 (https=)
CA (1) CA3252222A1 (https=)
CL (1) CL2024002600A1 (https=)
IL (1) IL314849A (https=)
MX (1) MX2024010609A (https=)
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CN117481629B (zh) * 2023-12-29 2024-03-26 成都水木医疗科技有限公司 一种多功能胶体渗透压仪及其测定方法和应用
WO2025214810A1 (en) * 2024-04-10 2025-10-16 Global Life Sciences Solutions Usa Llc Methods and apparatus for mixer characterization
CN121046585B (zh) * 2025-11-04 2026-02-24 深圳市残友细胞科技实验有限公司 一种基于多模态时序数据的细胞培养动态调控系统

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EP3164481A4 (en) * 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
JP7092879B2 (ja) * 2017-12-29 2022-06-28 エフ．ホフマン－ラ ロシュ アーゲー 細胞培養物の代謝状態の予測
EP3766000A2 (en) * 2018-03-16 2021-01-20 The United States of America as represented by the Secretary of the Department of Health and Human Services Using machine learning and/or neural networks to validate stem cells and their derivatives for use in cell therapy, drug discovery, and diagnostics
MX2021004510A (es) * 2018-10-23 2021-06-08 Amgen Inc Calibracion automatica y mantenimiento automatico de modelos espectroscopicos de raman para predicciones en tiempo real.

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AR128639A1 (es) 2024-05-29
US20230279332A1 (en) 2023-09-07
MX2024010609A (es) 2024-09-06
US12590283B2 (en) 2026-03-31
WO2023167802A8 (en) 2024-09-12
IL314849A (en) 2024-10-01
CL2024002600A1 (es) 2025-01-31
AU2023228806A1 (en) 2024-08-22
WO2023167802A1 (en) 2023-09-07
CN118829718A (zh) 2024-10-22
EP4482938A1 (en) 2025-01-01
KR20240158250A (ko) 2024-11-04
TW202346567A (zh) 2023-12-01
CA3252222A1 (en) 2023-09-07

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