JP2025510666A - Ｃ４－カルボノチオエート置換トリプタミン誘導体および利用法関連する出願 - Google Patents

Ｃ４－カルボノチオエート置換トリプタミン誘導体および利用法関連する出願 Download PDF

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JP2025510666A
JP2025510666A JP2024555281A JP2024555281A JP2025510666A JP 2025510666 A JP2025510666 A JP 2025510666A JP 2024555281 A JP2024555281 A JP 2024555281A JP 2024555281 A JP2024555281 A JP 2024555281A JP 2025510666 A JP2025510666 A JP 2025510666A
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receptor
compound
formula
group
aryl group
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JP2025510666A5 (enExample
Inventor
エム． ヘーゲル，ジリアン
マティンフー，カヴェー
ジェイ． ファッキーニ，ピーター
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エンベリック バイオサイエンシズ カナダ インコーポレイテッド
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Priority claimed from PCT/CA2022/051266 external-priority patent/WO2023173197A1/en
Publication of JP2025510666A publication Critical patent/JP2025510666A/ja
Publication of JP2025510666A5 publication Critical patent/JP2025510666A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024555281A 2022-03-18 2022-08-22 Ｃ４－カルボノチオエート置換トリプタミン誘導体および利用法関連する出願 Pending JP2025510666A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263321440P 2022-03-18 2022-03-18
US63/321,440 2022-03-18
US202263347835P 2022-06-01 2022-06-01
US63/347,835 2022-06-01
PCT/CA2022/051266 WO2023173197A1 (en) 2022-03-18 2022-08-22 C4-carbonothioate-substituted tryptamine derivatives and methods of using

Publications (2)

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JP2025510666A true JP2025510666A (ja) 2025-04-15
JP2025510666A5 JP2025510666A5 (enExample) 2025-08-26

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JP2024555281A Pending JP2025510666A (ja) 2022-03-18 2022-08-22 Ｃ４－カルボノチオエート置換トリプタミン誘導体および利用法関連する出願

Country Status (5)

Country Link
US (1) US20250206701A1 (enExample)
EP (1) EP4493542A4 (enExample)
JP (1) JP2025510666A (enExample)
AU (1) AU2022447256A1 (enExample)
CA (1) CA3246231A1 (enExample)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020181194A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
US20210002226A1 (en) * 2017-04-14 2021-01-07 Kempharm, Inc. Levorphanol prodrugs and processes for making and using them
US20210403425A1 (en) * 2020-06-30 2021-12-30 Field Trip Psychedelics Inc. Tryptamine prodrugs
WO2022038299A1 (en) * 2020-08-21 2022-02-24 Compass Pathfinder Limited Novel psilocin derivatives having prodrug properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4174016B2 (ja) * 2003-07-11 2008-10-29 株式会社ビーエル 競合法によるサイロシン類のイムノクロマトグラフィー検出法及びテストキット
US8349898B2 (en) * 2008-11-18 2013-01-08 Wisconsin Alumni Research Foundation Sigma-1 receptor ligands and methods of use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210002226A1 (en) * 2017-04-14 2021-01-07 Kempharm, Inc. Levorphanol prodrugs and processes for making and using them
WO2020181194A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
US20210403425A1 (en) * 2020-06-30 2021-12-30 Field Trip Psychedelics Inc. Tryptamine prodrugs
WO2022038299A1 (en) * 2020-08-21 2022-02-24 Compass Pathfinder Limited Novel psilocin derivatives having prodrug properties

Also Published As

Publication number Publication date
EP4493542A1 (en) 2025-01-22
AU2022447256A1 (en) 2024-11-07
US20250206701A1 (en) 2025-06-26
CA3246231A1 (en) 2023-09-21
EP4493542A4 (en) 2026-03-04

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