JP2025509233A - デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド - Google Patents

デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド Download PDF

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Publication number
JP2025509233A
JP2025509233A JP2024553171A JP2024553171A JP2025509233A JP 2025509233 A JP2025509233 A JP 2025509233A JP 2024553171 A JP2024553171 A JP 2024553171A JP 2024553171 A JP2024553171 A JP 2024553171A JP 2025509233 A JP2025509233 A JP 2025509233A
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JP
Japan
Prior art keywords
seq
polypeptide
amino acid
deamidase
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2024553171A
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English (en)
Japanese (ja)
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JP2025509233A5 (https=
Inventor
マウヌス エクローフ イェンス
Original Assignee
ノボザイムス アクティーゼルスカブ
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Filing date
Publication date
Priority claimed from EP22160942.3A external-priority patent/EP4242303A1/en
Application filed by ノボザイムス アクティーゼルスカブ filed Critical ノボザイムス アクティーゼルスカブ
Publication of JP2025509233A publication Critical patent/JP2025509233A/ja
Publication of JP2025509233A5 publication Critical patent/JP2025509233A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01044—Protein-glutamine glutaminase (3.5.1.44)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2024553171A 2022-03-08 2023-03-08 デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド Pending JP2025509233A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22160942.3 2022-03-08
EP22160942.3A EP4242303A1 (en) 2022-03-08 2022-03-08 Fusion polypeptides with deamidase inhibitor and deamidase domains
EP22183793 2022-07-08
EP22183793.3 2022-07-08
PCT/EP2023/055936 WO2023170177A1 (en) 2022-03-08 2023-03-08 Fusion polypeptides with deamidase inhibitor and deamidase domains

Publications (2)

Publication Number Publication Date
JP2025509233A true JP2025509233A (ja) 2025-04-11
JP2025509233A5 JP2025509233A5 (https=) 2026-03-16

Family

ID=85477826

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024553171A Pending JP2025509233A (ja) 2022-03-08 2023-03-08 デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド

Country Status (6)

Country Link
US (1) US20250215412A1 (https=)
EP (1) EP4490286A1 (https=)
JP (1) JP2025509233A (https=)
AU (1) AU2023231428A1 (https=)
CA (1) CA3242405A1 (https=)
WO (1) WO2023170177A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025008283A1 (en) 2023-07-05 2025-01-09 Novozymes A/S Foamable dairy products
WO2025132872A1 (en) 2023-12-20 2025-06-26 Novozymes A/S Modified leguminous protein with improved colloidal stability
WO2025233389A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
WO2025233391A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
WO2026060197A1 (en) * 2024-09-13 2026-03-19 International N&H Denmark Aps Novel protein glutaminase for plant based beverages
WO2026073574A1 (en) 2024-10-01 2026-04-09 Novozymes A/S Codon optimized deamidase expression
WO2026076952A1 (en) 2024-10-08 2026-04-16 Novozymes A/S Processes for obtaining dairy protein-based ready-to-drink beverages

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GB1483591A (en) 1973-07-23 1977-08-24 Novo Industri As Process for coating water soluble or water dispersible particles by means of the fluid bed technique
GB1590432A (en) 1976-07-07 1981-06-03 Novo Industri As Process for the production of an enzyme granulate and the enzyme granuate thus produced
DK263584D0 (da) 1984-05-29 1984-05-29 Novo Industri As Enzymholdige granulater anvendt som detergentadditiver
US4713245A (en) 1984-06-04 1987-12-15 Mitsui Toatsu Chemicals, Incorporated Granule containing physiologically-active substance, method for preparing same and use thereof
EG18543A (en) 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
DK435587D0 (da) 1987-08-21 1987-08-21 Novo Industri As Fremgangsmaade til fremstilling af et enzymholdigt granulat
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
DK78089D0 (da) 1989-02-20 1989-02-20 Novo Industri As Detergentholdigt granulat og fremgangsmaade til fremstilling deraf
ES2094155T3 (es) 1989-06-13 1997-01-16 Genencor Int Procedimiento para la neutralizacion de celulas sin lisis celular.
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
KR100278498B1 (ko) 1991-10-07 2001-01-15 웨인 에이치. 피쳐 피복된 효소함유 과립
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FR2704860B1 (fr) 1993-05-05 1995-07-13 Pasteur Institut Sequences de nucleotides du locus cryiiia pour le controle de l'expression de sequences d'adn dans un hote cellulaire.
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Also Published As

Publication number Publication date
AU2023231428A1 (en) 2024-07-11
CA3242405A1 (en) 2023-09-14
EP4490286A1 (en) 2025-01-15
WO2023170177A1 (en) 2023-09-14
WO2023170177A8 (en) 2023-11-09
US20250215412A1 (en) 2025-07-03

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