|
US4151042A
(en)
|
1977-03-31 |
1979-04-24 |
Takeda Chemical Industries, Ltd. |
Method for producing maytansinol and its derivatives
|
|
US4137230A
(en)
|
1977-11-14 |
1979-01-30 |
Takeda Chemical Industries, Ltd. |
Method for the production of maytansinoids
|
|
US4265814A
(en)
|
1978-03-24 |
1981-05-05 |
Takeda Chemical Industries |
Matansinol 3-n-hexadecanoate
|
|
JPS5562090A
(en)
|
1978-10-27 |
1980-05-10 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS5566585A
(en)
|
1978-11-14 |
1980-05-20 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164687A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS55164685A
(en)
|
1979-06-08 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
JPS55164686A
(en)
|
1979-06-11 |
1980-12-22 |
Takeda Chem Ind Ltd |
Novel maytansinoid compound and its preparation
|
|
US4309428A
(en)
|
1979-07-30 |
1982-01-05 |
Takeda Chemical Industries, Ltd. |
Maytansinoids
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US6660510B2
(en)
|
2001-12-17 |
2003-12-09 |
Food Industry Research And Development |
Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
US7871607B2
(en)
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
CA2556752C
(en)
|
2004-02-23 |
2016-02-02 |
Genentech, Inc. |
Heterocyclic self-immolative linkers and conjugates
|
|
EP2123756B1
(en)
|
2007-02-15 |
2014-06-04 |
Ajinomoto Co., Inc. |
Transglutaminase having disulfide bond introduced therein
|
|
WO2008102007A1
(en)
|
2007-02-22 |
2008-08-28 |
Novo Nordisk Health Care Ag |
Transglutaminase variants with improved specificity
|
|
EP2197443A4
(en)
|
2007-09-26 |
2014-01-01 |
Gemin X Pharmaceuticals Canada Inc |
COMPOSITIONS AND METHOD FOR LEADING NAD + MIRRORS USING A NICOTINAMIDE PHOSPHORIBOSYL TRANSFERASE HEMMER
|
|
MX2011010469A
(es)
|
2009-04-08 |
2012-03-14 |
Deutsches Krebsforsch |
Radicales de enlace al objetivo, armados con amatoxina para el tratamiento del cancer.
|
|
EP3192529B1
(en)
|
2009-04-08 |
2020-03-25 |
Faulstich, Heinz, Dr. |
Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy
|
|
AR082886A1
(es)
|
2010-09-03 |
2013-01-16 |
Forma Therapeutics Inc |
Compuestos y composiciones farmaceuticas que los contienen
|
|
ES2402254T3
(es)
|
2010-09-30 |
2013-04-30 |
Heidelberg Pharma Ag |
Conjugados de amatoxinas con ligadores mejorados
|
|
CA2813411C
(en)
|
2010-11-05 |
2016-08-02 |
Rinat Neuroscience Corporation |
Engineered polypeptide conjugates and methods for making thereof using transglutaminase
|
|
EP2497499A1
(en)
|
2011-03-10 |
2012-09-12 |
Heidelberg Pharma GmbH |
Amatoxin-conjugates with improved linkages
|
|
CA2858806A1
(en)
|
2011-12-23 |
2013-06-27 |
Innate Pharma |
Enzymatic conjugation of polypeptides
|
|
EP2774624A1
(en)
|
2013-03-04 |
2014-09-10 |
Heidelberg Pharma GmbH |
Amatoxin derivatives
|
|
US10195289B2
(en)
|
2013-07-31 |
2019-02-05 |
Rinat Neuroscience Corp. |
Engineered polypeptide conjugates using transglutaminase
|
|
WO2015054060A1
(en)
|
2013-10-09 |
2015-04-16 |
Eli Lilly And Company |
Novel pyridyloxyacetyl tetrahydroisoquinoline compounds useful as nampt inhibitors
|
|
CA2951887A1
(en)
|
2014-06-12 |
2015-12-17 |
Cspc Dophen Corporation |
Homogenous antibody drug conjugates via enzymatic methods
|
|
ES2736106T3
(es)
|
2015-03-10 |
2019-12-26 |
Bristol Myers Squibb Co |
Anticuerpos que se pueden conjugar mediante la transglutaminasa y conjugados producidos a partir de ellos
|
|
EP3069734A1
(en)
|
2015-03-17 |
2016-09-21 |
Exiris S.r.l. |
Cryptophycin-based antibody-drug conjugates with novel self-immolative linkers
|
|
WO2017025179A1
(en)
|
2015-08-07 |
2017-02-16 |
Merck Patent Gmbh |
A transglutamine tag for efficient site-specific bioconjugation
|
|
TWI714661B
(zh)
|
2015-11-05 |
2021-01-01 |
法商賽諾菲公司 |
新穎念珠藻素化合物及接合物、其製備與其治療用途
|
|
SG10201900628RA
(en)
|
2016-04-07 |
2019-02-27 |
Glaxosmithkline Ip Dev Ltd |
Heterocyclic amides useful as protein modulators
|
|
AU2018224486A1
(en)
*
|
2017-02-24 |
2019-10-03 |
Philogen Spa |
Immunocytokine combination therapy
|
|
WO2018206635A1
(en)
|
2017-05-10 |
2018-11-15 |
Sanofi |
Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation
|
|
AU2018337671B2
(en)
|
2017-09-19 |
2021-03-04 |
Paul Scherrer Institut |
Transglutaminase conjugation method and linker
|
|
CA3082271A1
(en)
*
|
2017-11-14 |
2019-05-23 |
Debiopharm Research & Manufacturing S.A. |
Ligand-drug-conjugates as substrates for selective cleavage by the exopeptidase activity of cathepsin b
|
|
CN113613679A
(zh)
|
2019-03-19 |
2021-11-05 |
保罗·谢勒学院 |
基于甘氨酸的接头的转谷氨酰胺酶缀合方法
|