JP2025506383A - アフリベルセプトをコードするａａｖ２バリアントを使用して眼内血管新生疾患を処置する方法 - Google Patents

アフリベルセプトをコードするａａｖ２バリアントを使用して眼内血管新生疾患を処置する方法 Download PDF

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JP2025506383A
JP2025506383A JP2024545929A JP2024545929A JP2025506383A JP 2025506383 A JP2025506383 A JP 2025506383A JP 2024545929 A JP2024545929 A JP 2024545929A JP 2024545929 A JP2024545929 A JP 2024545929A JP 2025506383 A JP2025506383 A JP 2025506383A
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unit dose
eye
raav particles
administration
weeks
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JP2025506383A5 (cg-RX-API-DMAC10.html
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ケリー ハンナ，
ケリー シェーファー－スウェール，
ブリジット ライリー，
ルスラン グリシャニン，
アダム トゥルプク，
リチャード ベックマン，
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アドヴェラム バイオテクノロジーズ， インコーポレイテッド
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Publication of JP2025506383A publication Critical patent/JP2025506383A/ja
Publication of JP2025506383A5 publication Critical patent/JP2025506383A5/ja
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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  • Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2024545929A 2022-02-02 2023-02-01 アフリベルセプトをコードするａａｖ２バリアントを使用して眼内血管新生疾患を処置する方法 Pending JP2025506383A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US202263305838P 2022-02-02 2022-02-02
US63/305,838 2022-02-02
US202263336191P 2022-04-28 2022-04-28
US63/336,191 2022-04-28
US202263336789P 2022-04-29 2022-04-29
US63/336,789 2022-04-29
US202263339795P 2022-05-09 2022-05-09
US63/339,795 2022-05-09
US202263435103P 2022-12-23 2022-12-23
US63/435,103 2022-12-23
PCT/US2023/061769 WO2023150566A1 (en) 2022-02-02 2023-02-01 Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Publications (2)

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JP2025506383A true JP2025506383A (ja) 2025-03-11
JP2025506383A5 JP2025506383A5 (cg-RX-API-DMAC10.html) 2026-02-25

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JP2024545929A Pending JP2025506383A (ja) 2022-02-02 2023-02-01 アフリベルセプトをコードするａａｖ２バリアントを使用して眼内血管新生疾患を処置する方法

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US (1) US20250137011A1 (cg-RX-API-DMAC10.html)
EP (1) EP4473003A1 (cg-RX-API-DMAC10.html)
JP (1) JP2025506383A (cg-RX-API-DMAC10.html)
KR (1) KR20240145489A (cg-RX-API-DMAC10.html)
AU (1) AU2023216244A1 (cg-RX-API-DMAC10.html)
CA (1) CA3243256A1 (cg-RX-API-DMAC10.html)
IL (1) IL314455A (cg-RX-API-DMAC10.html)
MX (1) MX2024009478A (cg-RX-API-DMAC10.html)
WO (1) WO2023150566A1 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20240329A1 (es) 2019-06-05 2024-02-27 Regeneron Pharma Dispositivos y metodos para administracion de dosis de precision
US12649031B2 (en) 2021-09-08 2026-06-09 Regeneron Pharmaceuticals, Inc. Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
WO2025010334A2 (en) * 2023-07-05 2025-01-09 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
TW202607144A (zh) * 2024-07-16 2026-02-16 美商愛德維仁生物科技公司 使用編碼阿柏西普（ａｆｌｉｂｅｒｃｅｐｔ）之ａａｖ２變異體治療眼部新生血管性疾病的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3693025T3 (da) 2011-04-22 2022-01-10 Univ California Adenoassocierede virus-virioner med variant capsid og fremgangsmåder til anvendelse heraf
KR102616820B1 (ko) 2017-03-17 2023-12-21 애드베룸 바이오테크놀로지스, 인코포레이티드 향상된 유전자 발현을 위한 조성물 및 방법
MX2020003945A (es) * 2017-10-18 2020-11-09 Regenxbio Inc Tratamiento de enfermedades oculares y cancer de colon metastasico con vegf-trap humano modificado post-traduccionalmente .
AU2021313839A1 (en) * 2020-07-21 2023-03-23 FTGEN Corp Composition and method for treating eye diseases

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WO2023150566A1 (en) 2023-08-10
CA3243256A1 (en) 2023-08-10
AU2023216244A1 (en) 2024-08-08
KR20240145489A (ko) 2024-10-07
US20250137011A1 (en) 2025-05-01
IL314455A (en) 2024-09-01
EP4473003A1 (en) 2024-12-11
MX2024009478A (es) 2024-11-08

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