JP2025504481A - ナノボディ-薬物付加物およびその使用 - Google Patents

ナノボディ-薬物付加物およびその使用 Download PDF

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JP2025504481A
JP2025504481A JP2024543162A JP2024543162A JP2025504481A JP 2025504481 A JP2025504481 A JP 2025504481A JP 2024543162 A JP2024543162 A JP 2024543162A JP 2024543162 A JP2024543162 A JP 2024543162A JP 2025504481 A JP2025504481 A JP 2025504481A
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cell
conjugate
cancer
virus
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JP2025504481A5 (https=
Inventor
プロー,ヒド,エル.
リウ,シン
ピシェーシャ,ノヴァリア
ヴェルハー,エリーシャ
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Boston Childrens Hospital
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Boston Childrens Hospital
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    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205Plasmodium
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/42Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
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    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]

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JP2024543162A 2022-01-19 2023-01-19 ナノボディ-薬物付加物およびその使用 Pending JP2025504481A (ja)

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US202263300995P 2022-01-19 2022-01-19
US63/300,995 2022-01-19
US202263423667P 2022-11-08 2022-11-08
US63/423,667 2022-11-08
PCT/US2023/060893 WO2023141500A2 (en) 2022-01-19 2023-01-19 Nanobody-drug adducts and uses thereof

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JP2025504481A true JP2025504481A (ja) 2025-02-12
JP2025504481A5 JP2025504481A5 (https=) 2026-01-27

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