JP2025503625A - 非ステロイド性抗炎症薬を含む涙小管内挿入物 - Google Patents

非ステロイド性抗炎症薬を含む涙小管内挿入物 Download PDF

Info

Publication number
JP2025503625A
JP2025503625A JP2024541021A JP2024541021A JP2025503625A JP 2025503625 A JP2025503625 A JP 2025503625A JP 2024541021 A JP2024541021 A JP 2024541021A JP 2024541021 A JP2024541021 A JP 2024541021A JP 2025503625 A JP2025503625 A JP 2025503625A
Authority
JP
Japan
Prior art keywords
insert
sustained release
nepafenac
release biodegradable
biodegradable intraocular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024541021A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025503625A5 (cg-RX-API-DMAC7.html
Inventor
ブリザード，チャールズ，ディー．
デサイ，アンキタ
エル－ハイエク，ラミ
ゴールドステイン，マイケル
ジャレット，ピーター
ウズン，オクテイ
Original Assignee
オキュラ セラピューティクス，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by オキュラ セラピューティクス，インコーポレイテッド filed Critical オキュラ セラピューティクス，インコーポレイテッド
Publication of JP2025503625A publication Critical patent/JP2025503625A/ja
Publication of JP2025503625A5 publication Critical patent/JP2025503625A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024541021A 2022-01-09 2023-01-06 非ステロイド性抗炎症薬を含む涙小管内挿入物 Pending JP2025503625A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263297776P 2022-01-09 2022-01-09
US63/297,776 2022-01-09
PCT/US2023/010319 WO2023133276A1 (en) 2022-01-09 2023-01-06 Intracanalicular insert comprising a non-steroidal anti-inflammatory agent

Publications (2)

Publication Number Publication Date
JP2025503625A true JP2025503625A (ja) 2025-02-04
JP2025503625A5 JP2025503625A5 (cg-RX-API-DMAC7.html) 2026-01-14

Family

ID=87074140

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024541021A Pending JP2025503625A (ja) 2022-01-09 2023-01-06 非ステロイド性抗炎症薬を含む涙小管内挿入物

Country Status (6)

Country Link
US (1) US20250064760A1 (cg-RX-API-DMAC7.html)
EP (1) EP4460285A4 (cg-RX-API-DMAC7.html)
JP (1) JP2025503625A (cg-RX-API-DMAC7.html)
CN (1) CN118742291A (cg-RX-API-DMAC7.html)
CA (1) CA3246431A1 (cg-RX-API-DMAC7.html)
WO (1) WO2023133276A1 (cg-RX-API-DMAC7.html)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104490861A (zh) * 2014-11-21 2015-04-08 三明欣茂药业有限公司 一种缓释型奈帕芬胺眼用制剂
US10603274B2 (en) * 2016-09-30 2020-03-31 Mati Therapeutics Inc. Ophthalmic drug sustained release formulation and uses thereof
AU2020262932B2 (en) * 2019-04-25 2025-11-13 Ocular Therapeutix, Inc. Intracanalicular hydrogel inserts for the delivery of anesthetics
PT3861985T (pt) * 2020-02-06 2023-08-03 Ocular Therapeutix Inc Composições e métodos para tratar doenças oculares
PT3884929T (pt) * 2020-03-25 2023-08-09 Ocular Therapeutix Inc Implante ocular contendo um inibidor da tirosina cinase
EP4216929A1 (en) * 2020-09-24 2023-08-02 Ocular Therapeutix, Inc. Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent

Also Published As

Publication number Publication date
EP4460285A4 (en) 2025-12-31
WO2023133276A1 (en) 2023-07-13
US20250064760A1 (en) 2025-02-27
CA3246431A1 (en) 2023-07-13
EP4460285A1 (en) 2024-11-13
CN118742291A (zh) 2024-10-01

Similar Documents

Publication Publication Date Title
US12161753B2 (en) Sustained release biodegradable intracanalicular inserts comprising a hydrogel and an active agent
TWI910236B (zh) 包含水凝膠及環孢菌素之持續釋放可生物降解淚小管內插入物
CN120346152A (zh) 眼用水凝胶酪氨酸激酶抑制剂植入物
JP2024544025A (ja) 押し出しされる眼内挿入物またはインプラント及びその製造方法
JP2025513338A (ja) ｉｎ ｓｉｔｕで形成された共有結合を有する単一溶液ハイドロゲル、該ハイドロゲルを使用する組成物設計及び医療処置
JP2025503625A (ja) 非ステロイド性抗炎症薬を含む涙小管内挿入物
US20250114373A1 (en) Intracanalicular insert comprising an antimicrobial agent
CN120897764A (zh) 包含阿西替尼多晶型物iv的眼部植入物
WO2021222117A1 (en) Methods of treating allergic conjunctivitis
JP2023534952A (ja) グルココルチコイドを含む眼内挿入物
CN118591369A (zh) 挤出式眼部插入物或植入物及其方法
TWI911436B (zh) 生物可侵蝕之眼用藥物遞送插入物及治療方法
US20220183969A1 (en) Ocular insert containing a glucocorticoid
HK40090731A (zh) 包含水凝胶和环孢菌素的持续释放可生物降解泪小管内插入物
BR122024018825B1 (pt) Composição de depósito e uso da mesma para tratamento de uma condição ocular
BR112019005594B1 (pt) Composição de depósito intracameral e uso da mesma para tratamento de uma condição ocular

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260105

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20260105