JP2025501775A - ＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に対して特異的な抗体及びその使用 - Google Patents

ＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に対して特異的な抗体及びその使用 Download PDF

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JP2025501775A
JP2025501775A JP2024539010A JP2024539010A JP2025501775A JP 2025501775 A JP2025501775 A JP 2025501775A JP 2024539010 A JP2024539010 A JP 2024539010A JP 2024539010 A JP2024539010 A JP 2024539010A JP 2025501775 A JP2025501775 A JP 2025501775A
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antibody
antigen
cov
binding fragment
amino acid
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JP2025501775A5 (https=
Inventor
リン，クオ－イー
ウォン，チー－ヒューイ
ワン，ズー－ウェン
チャン，イー－シュアン
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Academia Sinica
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Academia Sinica
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024539010A 2021-12-27 2022-12-27 ＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に対して特異的な抗体及びその使用 Pending JP2025501775A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163266008P 2021-12-27 2021-12-27
US63/266,008 2021-12-27
PCT/US2022/082428 WO2023129928A2 (en) 2021-12-27 2022-12-27 Antibody specific to spike protein of sars-cov-2 and uses thereof

Publications (2)

Publication Number Publication Date
JP2025501775A true JP2025501775A (ja) 2025-01-23
JP2025501775A5 JP2025501775A5 (https=) 2025-02-06

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JP2024539010A Pending JP2025501775A (ja) 2021-12-27 2022-12-27 ＳＡＲＳ－ＣｏＶ－２のスパイクタンパク質に対して特異的な抗体及びその使用

Country Status (6)

Country Link
US (1) US20230279080A1 (https=)
EP (1) EP4457243A4 (https=)
JP (1) JP2025501775A (https=)
CN (1) CN120787235A (https=)
TW (1) TW202342511A (https=)
WO (1) WO2023129928A2 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
US12384811B2 (en) 2019-04-05 2025-08-12 Academia Sinica Sialidase-resistant saccharide and method of making and using the same
TWI870591B (zh) 2020-05-08 2025-01-21 中央研究院 嵌合流感疫苗
BR112023000666A2 (pt) 2021-04-12 2023-10-24 Academia Sinica Imunógeno, composição imunogênica, método para induzir uma resposta imune contra um coronavírus 2 da síndrome respiratória aguda grave e uso da composição imunogênica
TW202334429A (zh) 2021-10-01 2023-09-01 中央研究院 Sars-cov-2棘蛋白特異性抗體及其用途
AU2024252371B2 (en) 2023-04-08 2026-02-12 Rock Biomedical Inc. Methods and compositions for dendritic cell targeting nano-delivery
US12318485B2 (en) 2023-04-08 2025-06-03 Rock Biomedical, Inc. Methods and compositions for targeted delivery by polymersomes
WO2024238734A2 (en) 2023-05-17 2024-11-21 Rock Biomedical Inc. Mgat1 deficient cells and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180243434A1 (en) * 2015-09-09 2018-08-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
JP2021533732A (ja) * 2018-07-13 2021-12-09 シャンハイ ファーマエクスプローラー カンパニー，リミティド Ｓｅｍａ４ｄ抗体及びその製造方法と使用

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
EP2014681A1 (en) * 2007-07-12 2009-01-14 Pierre Fabre Medicament Novel antibodies inhibiting c-met dimerization, and uses thereof
RU2011111640A (ru) * 2008-08-29 2012-10-10 Симфоген А/С (Dk) Антитела против cd5
WO2017062496A2 (en) * 2015-10-05 2017-04-13 University Of Virginia Patent Foundation Anti-sas1b antibodies, associated methods of use, and compositions and methods for detecting and treating cancer
AU2018312563A1 (en) * 2017-08-01 2020-03-12 City Of Hope Anti-IL1RAP antibodies
KR20250107297A (ko) * 2020-04-02 2025-07-11 리제너론 파아마슈티컬스, 인크. 항-sars-cov-2 스파이크 당단백질 항체 및 항원-결합 단편

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180243434A1 (en) * 2015-09-09 2018-08-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
JP2021533732A (ja) * 2018-07-13 2021-12-09 シャンハイ ファーマエクスプローラー カンパニー，リミティド Ｓｅｍａ４ｄ抗体及びその製造方法と使用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CAO, Y ET AL.: "Omicron escapes the majority ofexisting SARS-CoV-2 neutralizing antibodies", NATURE, JPN6025051268, 2022, ISSN: 0005754650 *
DE VLIEGER D ET AL.: "Single-Domain Antibodies and Their Formatting to Combat Viral Infections", ANTIBODIES (BASEL), vol. Vol. 8 (1), JPN6025051269, 20 December 2018 (2018-12-20), ISSN: 0005754648 *
HAN-YI HUANG ET AL.: "Impact of glycosylation on a broad-spectrum vaccine againstSARS-CoV-2", BIORXIV, JPN6025051267, 25 May 2021 (2021-05-25), ISSN: 0005754649 *

Also Published As

Publication number Publication date
EP4457243A2 (en) 2024-11-06
TW202342511A (zh) 2023-11-01
WO2023129928A2 (en) 2023-07-06
US20230279080A1 (en) 2023-09-07
WO2023129928A3 (en) 2023-08-10
EP4457243A4 (en) 2025-12-17
CN120787235A (zh) 2025-10-14

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