JP2024543982A - がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体 - Google Patents

がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体 Download PDF

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Publication number
JP2024543982A
JP2024543982A JP2024532554A JP2024532554A JP2024543982A JP 2024543982 A JP2024543982 A JP 2024543982A JP 2024532554 A JP2024532554 A JP 2024532554A JP 2024532554 A JP2024532554 A JP 2024532554A JP 2024543982 A JP2024543982 A JP 2024543982A
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Japan
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alkyl
kras
compound
cancer
group
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Pending
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JP2024532554A
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English (en)
Japanese (ja)
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JP2024543982A5 (https=
Inventor
ブロカー，ヨアヒム
アボット，ジェイソン
ツイ，ジェンウェン
フェシク，スティーヴン・ダブリュー
フックス，ユリアン
ヘルデイス，ローレンツ
ホッジズ，ティム
リトル，アンドリュー
マントゥリディス，アンドレアス
ファン，ジェイソン
ラムハーター，ユルゲン
サルカール，ドルバ
スメスルスト，クリスティアン・アラン・パウル
スン，チー
トロイ，マティアス
ウォーターソン，アレックス
ヴィルディング，ビルギット
ヴュンベルク，トビアス
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Vanderbilt University
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Vanderbilt University
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Publication of JP2024543982A publication Critical patent/JP2024543982A/ja
Publication of JP2024543982A5 publication Critical patent/JP2024543982A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024532554A 2021-12-01 2022-11-30 がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体 Pending JP2024543982A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163284757P 2021-12-01 2021-12-01
US63/284,757 2021-12-01
PCT/EP2022/083930 WO2023099608A1 (en) 2021-12-01 2022-11-30 Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer

Publications (2)

Publication Number Publication Date
JP2024543982A true JP2024543982A (ja) 2024-11-26
JP2024543982A5 JP2024543982A5 (https=) 2025-12-03

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JP2024532554A Pending JP2024543982A (ja) 2021-12-01 2022-11-30 がんの処置のための縮環２－アミノ－３－シアノチオフェン及び誘導体

Country Status (6)

Country Link
US (1) US20250129095A1 (https=)
EP (1) EP4441056A1 (https=)
JP (1) JP2024543982A (https=)
CN (1) CN118613485A (https=)
TW (1) TW202337432A (https=)
WO (1) WO2023099608A1 (https=)

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Also Published As

Publication number Publication date
WO2023099608A1 (en) 2023-06-08
CN118613485A (zh) 2024-09-06
EP4441056A1 (en) 2024-10-09
US20250129095A1 (en) 2025-04-24
TW202337432A (zh) 2023-10-01

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