JP2024543198A - 中枢神経障害を治療する方法 - Google Patents

中枢神経障害を治療する方法 Download PDF

Info

Publication number
JP2024543198A
JP2024543198A JP2024532463A JP2024532463A JP2024543198A JP 2024543198 A JP2024543198 A JP 2024543198A JP 2024532463 A JP2024532463 A JP 2024532463A JP 2024532463 A JP2024532463 A JP 2024532463A JP 2024543198 A JP2024543198 A JP 2024543198A
Authority
JP
Japan
Prior art keywords
disease
disorder
group
certain embodiments
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024532463A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024543198A5 (https=
Inventor
リアン，ツォンシン
タン，ウェイ
Original Assignee
ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド filed Critical ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド
Publication of JP2024543198A publication Critical patent/JP2024543198A/ja
Publication of JP2024543198A5 publication Critical patent/JP2024543198A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024532463A 2021-09-13 2022-08-22 中枢神経障害を治療する方法 Pending JP2024543198A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202111069990.0 2021-09-13
CN202111069990 2021-09-13
PCT/CN2022/113807 WO2023035913A1 (en) 2021-09-13 2022-08-22 Methods of treating cns disorders

Publications (2)

Publication Number Publication Date
JP2024543198A true JP2024543198A (ja) 2024-11-19
JP2024543198A5 JP2024543198A5 (https=) 2025-08-27

Family

ID=85506085

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024532463A Pending JP2024543198A (ja) 2021-09-13 2022-08-22 中枢神経障害を治療する方法

Country Status (8)

Country Link
US (1) US20250032465A1 (https=)
EP (1) EP4419101A4 (https=)
JP (1) JP2024543198A (https=)
CN (2) CN116490180B (https=)
AU (1) AU2022342095A1 (https=)
CA (1) CA3239065A1 (https=)
IL (1) IL313097A (https=)
WO (1) WO2023035913A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023244611A1 (en) * 2022-06-13 2023-12-21 Emory University Uses of jak inhibitors in the management of inflammation-associated depression and central nervous system (cns) pathologies
CN120152713A (zh) * 2022-07-29 2025-06-13 昂胜医疗科技公司 三环芳基衍生物及其组合物和方法
WO2025224600A1 (en) 2024-04-21 2025-10-30 Biohaven Therapeutics Ltd. Treatment of alpha-synucleinopathies and neuroprotection
WO2025248468A1 (en) * 2024-05-28 2025-12-04 Biohaven Therapeutics Ltd. Use of tyk2/jak1 inhibitors to treat amyloid-related imaging abnormalities (aria)
WO2026032213A1 (zh) * 2024-08-08 2026-02-12 普罗思特(南京)生物科技有限公司 取代的三环衍生物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2473579B (en) * 2008-06-30 2013-01-30 Biotechnology Res Corp Ltd Stat3 and TYK2 as drug targets for neurodegenerative diseases
CN105636962B (zh) * 2013-10-15 2017-10-13 靳博涵 新型化合物、用途及其制备方法
MX390005B (es) * 2016-10-03 2025-03-20 Hangzhou Highlightll Pharmaceutical Co Ltd Inhibidores selectivos de jak1 novedosos y usos de los mismos.
BR112021024533A2 (pt) 2019-06-06 2022-01-18 Highlightll Pharmaceutical Hainan Co Ltd Método de síntese de composto de furoimidazopiridina, forma cristalina de composto de furoimidazopiridina, e forma cristalina de sal do mesmo
WO2020244349A1 (zh) * 2019-06-06 2020-12-10 广州高瓴制药有限公司 呋喃并咪唑并吡啶类化合物的合成方法、多晶型物、及盐的多晶型物

Also Published As

Publication number Publication date
AU2022342095A1 (en) 2024-06-27
US20250032465A1 (en) 2025-01-30
CN116490180B (zh) 2024-03-22
CN118059096A (zh) 2024-05-24
EP4419101A1 (en) 2024-08-28
CA3239065A1 (en) 2023-03-16
IL313097A (en) 2024-07-01
EP4419101A4 (en) 2025-09-03
WO2023035913A1 (en) 2023-03-16
CN116490180A (zh) 2023-07-25

Similar Documents

Publication Publication Date Title
US12209076B2 (en) Imidazolyl kinase inhibitors and uses thereof
US20220242865A1 (en) Inhibitors of cyclin-dependent kinases
US10633348B2 (en) Methods to treat lymphoplasmacytic lymphoma
US10457691B2 (en) Macrocyclic kinase inhibitors and uses thereof
US11406645B2 (en) Acetamide thienotriazolodiazepines and uses thereof
JP2024543198A (ja) 中枢神経障害を治療する方法
US20170008895A1 (en) Uses of diazepane derivatives
US12486289B2 (en) Tricyclic compounds as glycogen synthase kinase 3 (GSK3) inhibitors and uses thereof
JP2017526741A (ja) ジアゼパン誘導体およびその使用
CA2996974A1 (en) Cyano thienotriazolodiazepines and uses thereof
WO2016065138A1 (en) Thiazolyl-containing compounds for treating proliferative diseases
HK40094824B (zh) 治疗cns病症的方法
HK40094824A (zh) 治疗cns病症的方法
HK40108558A (zh) 治疗cns病症的方法

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20250228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250819

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20250819