JP2024540318A - Ｃｄ３８阻害剤としてのｎ－（４－アミノシクロヘキシル）ピリミジン－４－カルボキサミド誘導体 - Google Patents
Ｃｄ３８阻害剤としてのｎ－（４－アミノシクロヘキシル）ピリミジン－４－カルボキサミド誘導体 Download PDFInfo
- Publication number
- JP2024540318A JP2024540318A JP2024526654A JP2024526654A JP2024540318A JP 2024540318 A JP2024540318 A JP 2024540318A JP 2024526654 A JP2024526654 A JP 2024526654A JP 2024526654 A JP2024526654 A JP 2024526654A JP 2024540318 A JP2024540318 A JP 2024540318A
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- imidazol
- mmol
- cyclohexyl
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB202116077 | 2021-11-09 | ||
| GB2116077.5 | 2021-11-09 | ||
| PCT/GB2022/052833 WO2023084206A1 (en) | 2021-11-09 | 2022-11-09 | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as cd38 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024540318A true JP2024540318A (ja) | 2024-10-31 |
| JPWO2023084206A5 JPWO2023084206A5 (https=) | 2025-11-18 |
| JP2024540318A5 JP2024540318A5 (https=) | 2025-11-18 |
Family
ID=84360092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024526654A Pending JP2024540318A (ja) | 2021-11-09 | 2022-11-09 | Ｃｄ３８阻害剤としてのｎ－（４－アミノシクロヘキシル）ピリミジン－４－カルボキサミド誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250019369A1 (https=) |
| EP (1) | EP4430034A1 (https=) |
| JP (1) | JP2024540318A (https=) |
| CN (1) | CN118317955A (https=) |
| CA (1) | CA3236793A1 (https=) |
| WO (1) | WO2023084206A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023235880A1 (en) * | 2022-06-02 | 2023-12-07 | Aeovian Pharmaceuticals, Inc. | Cd38 modulators and uses thereof |
| AU2024285368A1 (en) * | 2023-06-07 | 2025-12-18 | Flagship Pioneering Innovations Vi, Llc | Condensed azines as inhibitors of cyclic adp ribose hydrolase |
| WO2026000074A1 (en) * | 2024-06-25 | 2026-01-02 | Welnx Company Inc. | Use of cd38 inhibitors for reducing th2 inflammation |
| WO2026075971A1 (en) | 2024-10-01 | 2026-04-09 | Neolaia Inc. | Combination therapy for treatment of metabolic disorders and inflamation related disorders using incretin compounds and cd38 inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021021986A1 (en) | 2019-07-31 | 2021-02-04 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of cd38 |
| BR112022020291A2 (pt) * | 2020-04-07 | 2022-12-06 | Mitobridge Inc | Inibidores de cd38 |
| US20240254113A1 (en) * | 2021-04-30 | 2024-08-01 | Nanjing Immunophage Biotech Co., Ltd. | Compounds and their uses as cd38 inhibitors |
-
2022
- 2022-11-09 CA CA3236793A patent/CA3236793A1/en active Pending
- 2022-11-09 EP EP22805932.5A patent/EP4430034A1/en active Pending
- 2022-11-09 JP JP2024526654A patent/JP2024540318A/ja active Pending
- 2022-11-09 US US18/708,486 patent/US20250019369A1/en active Pending
- 2022-11-09 WO PCT/GB2022/052833 patent/WO2023084206A1/en not_active Ceased
- 2022-11-09 CN CN202280073666.2A patent/CN118317955A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN118317955A (zh) | 2024-07-09 |
| US20250019369A1 (en) | 2025-01-16 |
| EP4430034A1 (en) | 2024-09-18 |
| CA3236793A1 (en) | 2023-05-19 |
| WO2023084206A1 (en) | 2023-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20251110 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20251110 |