JP2024539093A - ２’－デオキシ－２’－ｆ－２’－ｃ－メチルヌクレオチドを有するオリゴヌクレオチド - Google Patents

２’－デオキシ－２’－ｆ－２’－ｃ－メチルヌクレオチドを有するオリゴヌクレオチド Download PDF

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JP2024539093A
JP2024539093A JP2024523413A JP2024523413A JP2024539093A JP 2024539093 A JP2024539093 A JP 2024539093A JP 2024523413 A JP2024523413 A JP 2024523413A JP 2024523413 A JP2024523413 A JP 2024523413A JP 2024539093 A JP2024539093 A JP 2024539093A
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optionally substituted
alkyl
dsrna
formula
nucleoside
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JP2024539093A5 (https=
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ムタイア マノハラン
成夫 松田
デゥルバジョティ ダッタ
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2024523413A 2021-10-19 2022-10-19 ２’－デオキシ－２’－ｆ－２’－ｃ－メチルヌクレオチドを有するオリゴヌクレオチド Pending JP2024539093A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163257289P 2021-10-19 2021-10-19
US63/257,289 2021-10-19
PCT/US2022/047102 WO2023069495A1 (en) 2021-10-19 2022-10-19 Oligonucleotides with 2'-deoxy-2'-f-2'-c-methyl nucleotides

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JP2024539093A true JP2024539093A (ja) 2024-10-28
JP2024539093A5 JP2024539093A5 (https=) 2025-10-23

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JP2024523413A Pending JP2024539093A (ja) 2021-10-19 2022-10-19 ２’－デオキシ－２’－ｆ－２’－ｃ－メチルヌクレオチドを有するオリゴヌクレオチド

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US (1) US20250223588A1 (https=)
EP (1) EP4419536A4 (https=)
JP (1) JP2024539093A (https=)
WO (1) WO2023069495A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024259190A2 (en) * 2023-06-15 2024-12-19 Alnylam Pharmaceuticals, Inc. 5'-modified monomers, oligonucleotides and double-stranded rnas
CN118063533B (zh) * 2023-09-18 2024-08-27 广州必贝特医药股份有限公司 修饰的核苷酸化合物、其寡聚核苷酸及其应用
WO2025260011A1 (en) * 2024-06-14 2025-12-18 Alnylam Pharmaceuticals, Inc. 5'-modified monomers, oligonucleotides and double-stranded rnas
WO2025259992A1 (en) * 2024-06-14 2025-12-18 Alnylam Pharmaceuticals, Inc. 5'-modified monomers, oligonucleotides and double-stranded rnas

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008100447A2 (en) * 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
US20110130440A1 (en) * 2008-03-26 2011-06-02 Alnylam Pharmaceuticals, Inc. Non-natural ribonucleotides, and methods of use thereof
US20120059045A1 (en) * 2008-10-24 2012-03-08 Isis Pharmaceuticals, Inc. Methods of using oligomeric compounds comprising 2'-substituted nucleosides
AU2010221419B2 (en) * 2009-03-02 2015-10-01 Alnylam Pharmaceuticals, Inc. Nucleic acid chemical modifications
WO2011005860A2 (en) * 2009-07-07 2011-01-13 Alnylam Pharmaceuticals, Inc. 5' phosphate mimics
HUE051986T2 (hu) * 2014-06-24 2021-04-28 Janssen Biopharma Inc Helyettesített nukleozidok, nukleotidek és analógjaik virális fertõzés kezelésére való alkalmazásra
IL316808A (en) * 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2020051398A1 (en) * 2018-09-06 2020-03-12 Aptamir Therapeutics, Inc. Metabolic benefits of short mir-22 mirna antagomir therapies
US11820985B2 (en) * 2019-03-26 2023-11-21 University Of Massachusetts Modified oligonucleotides with increased stability
AU2020358016A1 (en) * 2019-10-02 2022-04-21 Dicerna Pharmaceuticals, Inc. Chemical modifications of small interfering RNA with minimal fluorine content

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Publication number Publication date
EP4419536A4 (en) 2026-04-15
WO2023069495A1 (en) 2023-04-27
US20250223588A1 (en) 2025-07-10
EP4419536A1 (en) 2024-08-28

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