JP2024537279A - 合成ゲノム編集システム - Google Patents
合成ゲノム編集システム Download PDFInfo
- Publication number
- JP2024537279A JP2024537279A JP2024521748A JP2024521748A JP2024537279A JP 2024537279 A JP2024537279 A JP 2024537279A JP 2024521748 A JP2024521748 A JP 2024521748A JP 2024521748 A JP2024521748 A JP 2024521748A JP 2024537279 A JP2024537279 A JP 2024537279A
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- nucleic acid
- target
- dbd
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/85—Fusion polypeptide containing an RNA binding domain
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2114453.0 | 2021-10-08 | ||
| GBGB2114453.0A GB202114453D0 (en) | 2021-10-08 | 2021-10-08 | Synthetic genome editing system |
| GBGB2209735.6A GB202209735D0 (en) | 2022-07-01 | 2022-07-01 | Synthetic genome editing system |
| GB2209735.6 | 2022-07-01 | ||
| PCT/GB2022/052555 WO2023057777A1 (en) | 2021-10-08 | 2022-10-07 | Synthetic genome editing system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024537279A true JP2024537279A (ja) | 2024-10-10 |
| JP2024537279A5 JP2024537279A5 (https=) | 2025-10-15 |
| JPWO2023057777A5 JPWO2023057777A5 (https=) | 2025-10-15 |
Family
ID=83902914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024521748A Pending JP2024537279A (ja) | 2021-10-08 | 2022-10-07 | 合成ゲノム編集システム |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20260009008A1 (https=) |
| EP (2) | EP4636084A3 (https=) |
| JP (1) | JP2024537279A (https=) |
| KR (1) | KR20240082405A (https=) |
| AU (1) | AU2022360286A1 (https=) |
| CA (1) | CA3234338A1 (https=) |
| ES (1) | ES3041112T3 (https=) |
| IL (1) | IL311961A (https=) |
| WO (1) | WO2023057777A1 (https=) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12014501360B1 (en) | 2011-12-16 | 2022-05-20 | Targetgene Biotechnologies Ltd | Compositions and methods for modifying a predetermined target nucleic acid sequence |
| WO2020142676A1 (en) * | 2019-01-04 | 2020-07-09 | The University Of Chicago | Systems and methods for modulating rna |
| IL292571A (en) * | 2019-10-28 | 2022-06-01 | Targetgene Biotechnologies Ltd | Pam-reduced and pam-abolished cas derivatives compositions and uses thereof in genetic modulation |
| GB202010692D0 (en) | 2020-07-10 | 2020-08-26 | Horizon Discovery Ltd | RNA scaffolds |
-
2022
- 2022-10-07 KR KR1020247015096A patent/KR20240082405A/ko active Pending
- 2022-10-07 EP EP25195247.9A patent/EP4636084A3/en active Pending
- 2022-10-07 IL IL311961A patent/IL311961A/en unknown
- 2022-10-07 US US18/698,875 patent/US20260009008A1/en active Pending
- 2022-10-07 EP EP22793205.0A patent/EP4413140B1/en active Active
- 2022-10-07 JP JP2024521748A patent/JP2024537279A/ja active Pending
- 2022-10-07 ES ES22793205T patent/ES3041112T3/es active Active
- 2022-10-07 CA CA3234338A patent/CA3234338A1/en active Pending
- 2022-10-07 WO PCT/GB2022/052555 patent/WO2023057777A1/en not_active Ceased
- 2022-10-07 AU AU2022360286A patent/AU2022360286A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4413140A1 (en) | 2024-08-14 |
| EP4413140C0 (en) | 2025-08-13 |
| WO2023057777A1 (en) | 2023-04-13 |
| CA3234338A1 (en) | 2023-04-13 |
| AU2022360286A1 (en) | 2024-05-02 |
| EP4636084A3 (en) | 2025-12-24 |
| EP4636084A2 (en) | 2025-10-22 |
| KR20240082405A (ko) | 2024-06-10 |
| IL311961A (en) | 2024-06-01 |
| ES3041112T3 (en) | 2025-11-07 |
| US20260009008A1 (en) | 2026-01-08 |
| EP4413140B1 (en) | 2025-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20251006 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20251006 |