JP2024535852A - ＡＮＧＰＴＬ４をサイレンシングするためのｉＲＮＡ組成物および方法 - Google Patents

ＡＮＧＰＴＬ４をサイレンシングするためのｉＲＮＡ組成物および方法 Download PDF

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JP2024535852A
JP2024535852A JP2024516862A JP2024516862A JP2024535852A JP 2024535852 A JP2024535852 A JP 2024535852A JP 2024516862 A JP2024516862 A JP 2024516862A JP 2024516862 A JP2024516862 A JP 2024516862A JP 2024535852 A JP2024535852 A JP 2024535852A
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nucleotides
dsrna agent
strand
angptl4
nucleotide
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JP2024516862A
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JP2024535852A5 (https=
Inventor
ズーバー，ジェフリー
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2024516862A 2021-09-17 2022-09-16 ＡＮＧＰＴＬ４をサイレンシングするためのｉＲＮＡ組成物および方法 Pending JP2024535852A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163245693P 2021-09-17 2021-09-17
US63/245,693 2021-09-17
US202263317480P 2022-03-07 2022-03-07
US63/317,480 2022-03-07
PCT/US2022/076613 WO2023044458A1 (en) 2021-09-17 2022-09-16 Irna compositions and methods for silencing angptl4

Publications (2)

Publication Number Publication Date
JP2024535852A true JP2024535852A (ja) 2024-10-02
JP2024535852A5 JP2024535852A5 (https=) 2025-11-06

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JP2024516862A Pending JP2024535852A (ja) 2021-09-17 2022-09-16 ＡＮＧＰＴＬ４をサイレンシングするためのｉＲＮＡ組成物および方法

Country Status (4)

Country Link
US (1) US20250136978A1 (https=)
EP (1) EP4402261A1 (https=)
JP (1) JP2024535852A (https=)
WO (1) WO2023044458A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119343148A (zh) * 2022-06-10 2025-01-21 南洋理工大学 使用angptl4拮抗剂治疗肝纤维化、炎症或相关疾病的方法
CN120019148A (zh) * 2023-08-22 2025-05-16 成都先衍生物技术有限公司 一种靶向ANGPTL4的siRNA及其缀合物和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194704A1 (en) * 2002-04-03 2003-10-16 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
CN115927335A (zh) * 2015-04-13 2023-04-07 阿尔尼拉姆医药品有限公司 类血管生成素3（ANGPTL3）iRNA组合物及其使用方法
CA3164050A1 (en) * 2019-12-09 2021-06-17 Empirico Inc. Oligonucleotides for treatment of angiopoietin like 4 (angptl4) related diseases

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WO2023044458A1 (en) 2023-03-23
US20250136978A1 (en) 2025-05-01
EP4402261A1 (en) 2024-07-24

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