JP2024535845A - 操作された抗微生物ペプチドおよびその使用方法 - Google Patents

操作された抗微生物ペプチドおよびその使用方法 Download PDF

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Publication number
JP2024535845A
JP2024535845A JP2024516797A JP2024516797A JP2024535845A JP 2024535845 A JP2024535845 A JP 2024535845A JP 2024516797 A JP2024516797 A JP 2024516797A JP 2024516797 A JP2024516797 A JP 2024516797A JP 2024535845 A JP2024535845 A JP 2024535845A
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Prior art keywords
arg
val
trp
pharmaceutical formulation
seq
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JP2024516797A
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English (en)
Japanese (ja)
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JP2024535845A5 (cg-RX-API-DMAC10.html
Inventor
ステックベック，ジョナサン，ディー．
ピコーン，ブラッド，エヌ．
ドビンズ，デスピナ，エックス．
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ぺプチロジックス，インク．
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Publication of JP2024535845A publication Critical patent/JP2024535845A/ja
Publication of JP2024535845A5 publication Critical patent/JP2024535845A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
JP2024516797A 2021-09-17 2022-09-14 操作された抗微生物ペプチドおよびその使用方法 Pending JP2024535845A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163245770P 2021-09-17 2021-09-17
US63/245,770 2021-09-17
US17/730,042 US20230106943A1 (en) 2021-09-17 2022-04-26 Engineered antimicrobial peptides and usage thereof
US17/730,042 2022-04-26
PCT/US2022/076421 WO2023044339A1 (en) 2021-09-17 2022-09-14 Engineered antimicrobial peptides and usage thereof

Publications (2)

Publication Number Publication Date
JP2024535845A true JP2024535845A (ja) 2024-10-02
JP2024535845A5 JP2024535845A5 (cg-RX-API-DMAC10.html) 2026-01-21

Family

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Application Number Title Priority Date Filing Date
JP2024516797A Pending JP2024535845A (ja) 2021-09-17 2022-09-14 操作された抗微生物ペプチドおよびその使用方法

Country Status (6)

Country Link
US (2) US20230106943A1 (cg-RX-API-DMAC10.html)
EP (1) EP4401754A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024535845A (cg-RX-API-DMAC10.html)
AU (1) AU2022345264A1 (cg-RX-API-DMAC10.html)
CA (1) CA3231957A1 (cg-RX-API-DMAC10.html)
WO (1) WO2023044339A1 (cg-RX-API-DMAC10.html)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008070083A2 (en) * 2006-12-04 2008-06-12 Keybay Pharma, Inc. Filter media using peptide-based antimicrobials
WO2019089657A1 (en) * 2017-10-30 2019-05-09 Allvivo Vascular, Inc. Delivery systems for administration of cationic biological actives
WO2021092382A1 (en) * 2019-11-08 2021-05-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions comprising antimicrobial peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030036627A1 (en) * 2001-02-16 2003-02-20 Montelaro Ronald C. Virus derived antimicrobial peptides
RS60101B1 (sr) * 2008-08-15 2020-05-29 Ironwood Pharmaceuticals Inc Formulacije koje sadrže linaklotid za oralnu primenu
US8530409B1 (en) * 2012-06-12 2013-09-10 Dipexium Pharmaceuticals LLC Stable pexiganan formulation
US11236314B2 (en) * 2017-03-30 2022-02-01 Bactoclear Holdings Pte. Ltd Chimeric lysm polypeptides
US20220249599A1 (en) * 2018-03-13 2022-08-11 Peptilogics, Inc. Treatment of implants with engineered antimicrobial amphiphilic peptides
EP4401752A4 (en) * 2021-09-17 2025-07-16 Peptilogics Inc MODIFIED ANTIMICROBIAL PEPTIDES AND THEIR USE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008070083A2 (en) * 2006-12-04 2008-06-12 Keybay Pharma, Inc. Filter media using peptide-based antimicrobials
WO2019089657A1 (en) * 2017-10-30 2019-05-09 Allvivo Vascular, Inc. Delivery systems for administration of cationic biological actives
WO2021092382A1 (en) * 2019-11-08 2021-05-14 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compositions comprising antimicrobial peptides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF ORTHOPAEDIC RESEARCH, vol. 38, JPN6026029653, 2020, pages 2657 - 2663, ISSN: 0005907522 *

Also Published As

Publication number Publication date
US20230106943A1 (en) 2023-04-06
AU2022345264A1 (en) 2024-04-04
EP4401754A1 (en) 2024-07-24
US20250195611A1 (en) 2025-06-19
EP4401754A4 (en) 2025-07-30
WO2023044339A1 (en) 2023-03-23
CA3231957A1 (en) 2023-03-23

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