JP2024534416A - 化合物、組成物及び方法 - Google Patents

化合物、組成物及び方法 Download PDF

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Publication number
JP2024534416A
JP2024534416A JP2024516756A JP2024516756A JP2024534416A JP 2024534416 A JP2024534416 A JP 2024534416A JP 2024516756 A JP2024516756 A JP 2024516756A JP 2024516756 A JP2024516756 A JP 2024516756A JP 2024534416 A JP2024534416 A JP 2024534416A
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JP
Japan
Prior art keywords
cycloalkyl
heterocyclyl
compound
heteroaryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024516756A
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English (en)
Japanese (ja)
Other versions
JP2024534416A5 (cg-RX-API-DMAC7.html
Inventor
ロバート エー． ザ セカンド クレイグ，
マクシム オシポフ，
アルン トートゥムカラ，
Original Assignee
ニコ セラピューティクス， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニコ セラピューティクス， インコーポレイテッド filed Critical ニコ セラピューティクス， インコーポレイテッド
Publication of JP2024534416A publication Critical patent/JP2024534416A/ja
Publication of JP2024534416A5 publication Critical patent/JP2024534416A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2024516756A 2021-09-17 2022-09-16 化合物、組成物及び方法 Pending JP2024534416A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163245747P 2021-09-17 2021-09-17
US63/245,747 2021-09-17
PCT/US2022/043860 WO2023044043A1 (en) 2021-09-17 2022-09-16 Compounds, compositions and methods

Publications (2)

Publication Number Publication Date
JP2024534416A true JP2024534416A (ja) 2024-09-20
JP2024534416A5 JP2024534416A5 (cg-RX-API-DMAC7.html) 2025-09-25

Family

ID=85602045

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024516756A Pending JP2024534416A (ja) 2021-09-17 2022-09-16 化合物、組成物及び方法

Country Status (5)

Country Link
US (1) US20240391932A1 (cg-RX-API-DMAC7.html)
EP (1) EP4401739A4 (cg-RX-API-DMAC7.html)
JP (1) JP2024534416A (cg-RX-API-DMAC7.html)
CN (1) CN118302170A (cg-RX-API-DMAC7.html)
WO (1) WO2023044043A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210038877A (ko) * 2018-07-25 2021-04-08 노파르티스 아게 Nlrp3 인플라마좀 억제제
JP2023523418A (ja) * 2020-04-23 2023-06-05 ヤンセン ファーマシューティカ エヌ．ベー． Ｎｌｒｐ３の阻害剤としての三環式化合物

Also Published As

Publication number Publication date
EP4401739A1 (en) 2024-07-24
US20240391932A1 (en) 2024-11-28
CN118302170A (zh) 2024-07-05
WO2023044043A1 (en) 2023-03-23
EP4401739A4 (en) 2025-07-30

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Legal Events

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Effective date: 20250916

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