JP2024532765A - Ｊａｋ阻害剤のプロドラッグを用いたｊａｋ阻害応答性障害の治療 - Google Patents

Ｊａｋ阻害剤のプロドラッグを用いたｊａｋ阻害応答性障害の治療 Download PDF

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Publication number
JP2024532765A
JP2024532765A JP2024508389A JP2024508389A JP2024532765A JP 2024532765 A JP2024532765 A JP 2024532765A JP 2024508389 A JP2024508389 A JP 2024508389A JP 2024508389 A JP2024508389 A JP 2024508389A JP 2024532765 A JP2024532765 A JP 2024532765A
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compound
pharma
deuterium
formula
acceptable salt
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JP2024508389A
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Japanese (ja)
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JP2024532765A5 (enExample
Inventor
モーガン，アダム・ジェイ
Original Assignee
サン ファーマシューティカル インダストリーズ，インコーポレイテッド
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Application filed by サン ファーマシューティカル インダストリーズ，インコーポレイテッド filed Critical サン ファーマシューティカル インダストリーズ，インコーポレイテッド
Publication of JP2024532765A publication Critical patent/JP2024532765A/ja
Publication of JP2024532765A5 publication Critical patent/JP2024532765A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2024508389A 2021-08-12 2022-08-12 Ｊａｋ阻害剤のプロドラッグを用いたｊａｋ阻害応答性障害の治療 Pending JP2024532765A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163232538P 2021-08-12 2021-08-12
US63/232,538 2021-08-12
US202163233059P 2021-08-13 2021-08-13
US63/233,059 2021-08-13
PCT/US2022/040190 WO2023018954A1 (en) 2021-08-12 2022-08-12 Treatment of jak-inhibition-responsive disorders with prodrugs of jak inhibitors

Publications (2)

Publication Number Publication Date
JP2024532765A true JP2024532765A (ja) 2024-09-10
JP2024532765A5 JP2024532765A5 (enExample) 2025-08-19

Family

ID=83188710

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024508389A Pending JP2024532765A (ja) 2021-08-12 2022-08-12 Ｊａｋ阻害剤のプロドラッグを用いたｊａｋ阻害応答性障害の治療

Country Status (6)

Country Link
US (1) US20240307401A1 (enExample)
EP (1) EP4384173A1 (enExample)
JP (1) JP2024532765A (enExample)
AU (1) AU2022328282A1 (enExample)
CA (1) CA3228509A1 (enExample)
WO (1) WO2023018954A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116870012A (zh) * 2023-07-26 2023-10-13 北京大学宁波海洋药物研究院 一类甾体硫酸酯化合物在制备jak激酶抑制剂中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9925962D0 (en) 1999-11-02 1999-12-29 Novartis Ag Organic compounds
PT1390063E (pt) 2001-05-03 2005-03-31 Hoffmann La Roche Forma de dosagem farmaceutica de mesilato de nelfinavir amorfo
US20060094744A1 (en) 2004-09-29 2006-05-04 Maryanoff Cynthia A Pharmaceutical dosage forms of stable amorphous rapamycin like compounds
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
PE20211639A1 (es) 2009-01-15 2021-08-24 Incyte Holdings Corp Procesos para preparar inhibidores de jak y compuestos intermediarios relacionado
DK3882249T3 (da) 2012-06-15 2025-08-25 Sun Pharmaceutical Ind Inc Deutererede derivater af ruxolitinib
LT3452039T (lt) 2016-05-04 2024-10-25 Sun Pharmaceutical Industries, Inc. Plaukų slinkimo sutrikimo gydymas deuterintais jak inhibitoriais
CN107759601B (zh) * 2016-08-23 2020-09-11 苏州旺山旺水生物医药有限公司 一种jak抑制剂及其盐的制备方法
JP2020520955A (ja) * 2017-05-23 2020-07-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ヤヌスキナーゼ阻害剤のグルクロニドプロドラッグ
CN107915738B (zh) 2017-11-14 2019-07-26 海化生命(厦门)科技有限公司 用于合成巴瑞替尼的关键中间体2的制备方法
CA3129096A1 (en) 2019-02-06 2020-08-13 Concert Pharmaceuticals, Inc. Process for preparing enantiomerically enriched jak inhibitors
KR20230044411A (ko) 2020-06-29 2023-04-04 콘서트 파마슈티컬즈, 인크. Jak 억제제를 제조하기 위한 방법 및 중간체

Also Published As

Publication number Publication date
EP4384173A1 (en) 2024-06-19
AU2022328282A1 (en) 2024-02-22
CA3228509A1 (en) 2023-02-16
WO2023018954A1 (en) 2023-02-16
US20240307401A1 (en) 2024-09-19

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