JP2024531446A - 癌免疫療法の増強のためのil-10発現細胞 - Google Patents
癌免疫療法の増強のためのil-10発現細胞 Download PDFInfo
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- JP2024531446A JP2024531446A JP2024510734A JP2024510734A JP2024531446A JP 2024531446 A JP2024531446 A JP 2024531446A JP 2024510734 A JP2024510734 A JP 2024510734A JP 2024510734 A JP2024510734 A JP 2024510734A JP 2024531446 A JP2024531446 A JP 2024531446A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4271—Melanoma antigens
- A61K40/4273—Glycoprotein 100 [Gp100]
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2066—IL-10
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- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
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- A61K2239/54—Pancreas
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/55—Lung
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- A—HUMAN NECESSITIES
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- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/231—Interleukin-10 (IL-10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2510/00—Genetically modified cells
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
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- Biophysics (AREA)
- Molecular Biology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- General Engineering & Computer Science (AREA)
- Hematology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21192853 | 2021-08-24 | ||
| EP21192853.6 | 2021-08-24 | ||
| PCT/EP2022/073462 WO2023025788A1 (en) | 2021-08-24 | 2022-08-23 | Il-10 expressing cells for enhanced cancer immunotherapies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024531446A true JP2024531446A (ja) | 2024-08-29 |
| JP2024531446A5 JP2024531446A5 (https=) | 2025-08-13 |
Family
ID=77499640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024510734A Pending JP2024531446A (ja) | 2021-08-24 | 2022-08-23 | 癌免疫療法の増強のためのil-10発現細胞 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20240424096A1 (https=) |
| EP (1) | EP4392549A1 (https=) |
| JP (1) | JP2024531446A (https=) |
| KR (1) | KR20240049813A (https=) |
| CN (1) | CN118043450A (https=) |
| AU (1) | AU2022334870A1 (https=) |
| CA (1) | CA3228536A1 (https=) |
| MX (1) | MX2024002436A (https=) |
| WO (1) | WO2023025788A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023129929A1 (en) * | 2021-12-30 | 2023-07-06 | Tr1X, Inc. | Cd4+ t cells expressing il-10 and chimeric antigen receptors and uses thereof |
| CN121100177A (zh) * | 2023-04-03 | 2025-12-09 | 香港北恒生物科技有限公司 | 靶向IL10和Claudin 18.2的工程化细胞及其用途 |
| WO2025148750A1 (zh) * | 2024-01-08 | 2025-07-17 | 上药生物治疗(香港)有限公司 | 膜表达il-10及其用途 |
| WO2026061386A1 (zh) * | 2024-09-18 | 2026-03-26 | 上药生物治疗(香港)有限公司 | Gpc3 car及其应用 |
| CN119331826B (zh) * | 2024-12-18 | 2025-08-05 | 智在汉青生物科技(浙江)有限公司 | 用于增强细胞免疫疗法的表达非分泌型il-10的免疫细胞、制备方法及用途 |
| CN119823288A (zh) * | 2025-03-19 | 2025-04-15 | 中山大学 | 一种靶向alppl2及her2蛋白的car-t细胞及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| KR20030032922A (ko) | 2000-02-24 | 2003-04-26 | 싸이트 테라피스 인코포레이티드 | 세포의 동시 자극 및 농축 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9987308B2 (en) | 2011-03-23 | 2018-06-05 | Fred Hutchinson Cancer Research Center | Method and compositions for cellular immunotherapy |
| US20160361415A1 (en) * | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
| AU2018367452B2 (en) * | 2017-11-14 | 2024-06-13 | Memorial Sloan-Kettering Cancer Center | IL-36 secreting immunoresponsive cells and uses thereof |
-
2022
- 2022-08-23 WO PCT/EP2022/073462 patent/WO2023025788A1/en not_active Ceased
- 2022-08-23 KR KR1020247007741A patent/KR20240049813A/ko active Pending
- 2022-08-23 CA CA3228536A patent/CA3228536A1/en active Pending
- 2022-08-23 AU AU2022334870A patent/AU2022334870A1/en active Pending
- 2022-08-23 US US18/684,249 patent/US20240424096A1/en active Pending
- 2022-08-23 CN CN202280064538.1A patent/CN118043450A/zh active Pending
- 2022-08-23 MX MX2024002436A patent/MX2024002436A/es unknown
- 2022-08-23 EP EP22776870.2A patent/EP4392549A1/en active Pending
- 2022-08-23 JP JP2024510734A patent/JP2024531446A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240424096A1 (en) | 2024-12-26 |
| AU2022334870A1 (en) | 2024-03-28 |
| EP4392549A1 (en) | 2024-07-03 |
| MX2024002436A (es) | 2024-06-03 |
| CN118043450A (zh) | 2024-05-14 |
| WO2023025788A1 (en) | 2023-03-02 |
| KR20240049813A (ko) | 2024-04-17 |
| CA3228536A1 (en) | 2023-03-02 |
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