JP2024529839A - Ｎｌｒｐ３モジュレーター - Google Patents
Ｎｌｒｐ３モジュレーター Download PDFInfo
- Publication number
- JP2024529839A JP2024529839A JP2023580379A JP2023580379A JP2024529839A JP 2024529839 A JP2024529839 A JP 2024529839A JP 2023580379 A JP2023580379 A JP 2023580379A JP 2023580379 A JP2023580379 A JP 2023580379A JP 2024529839 A JP2024529839 A JP 2024529839A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharma
- solvate
- acceptable salt
- ceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163216446P | 2021-06-29 | 2021-06-29 | |
| US63/216,446 | 2021-06-29 | ||
| US202263320155P | 2022-03-15 | 2022-03-15 | |
| US63/320,155 | 2022-03-15 | ||
| PCT/US2022/035306 WO2023278438A1 (en) | 2021-06-29 | 2022-06-28 | Nlrp3 modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024529839A true JP2024529839A (ja) | 2024-08-14 |
| JP2024529839A5 JP2024529839A5 (https=) | 2025-06-30 |
| JPWO2023278438A5 JPWO2023278438A5 (https=) | 2025-06-30 |
Family
ID=84692056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023580379A Pending JP2024529839A (ja) | 2021-06-29 | 2022-06-28 | Ｎｌｒｐ３モジュレーター |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240327413A1 (https=) |
| EP (1) | EP4362946A4 (https=) |
| JP (1) | JP2024529839A (https=) |
| TW (1) | TW202319054A (https=) |
| WO (1) | WO2023278438A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| HRP20251513T1 (hr) | 2021-07-02 | 2026-01-02 | Astrazeneca Ab | Inhibitori inflamasoma nlrp3 |
| MX2024000984A (es) * | 2021-07-21 | 2024-06-19 | Nico Therapeutics Inc | Compuesto de piridazina anilado. |
| IL310992A (en) | 2021-08-25 | 2024-04-01 | Ptc Therapeutics Inc | NLRP3 inhibitors |
| CN118302417A (zh) * | 2021-08-25 | 2024-07-05 | Ptc医疗公司 | Nlrp3抑制剂 |
| US20240391881A1 (en) * | 2021-09-30 | 2024-11-28 | Origiant Pharmaceutical Co., Ltd. | Pharmaceutical use and preparation method for substituted heteroaryl phthalazine derivative |
| CN116102535A (zh) | 2021-10-22 | 2023-05-12 | 索智生物科技（浙江）有限公司 | 一种含氮化合物、其制备方法及应用 |
| WO2023088856A1 (en) * | 2021-11-17 | 2023-05-25 | F. Hoffmann-La Roche Ag | Heterocyclic nlrp3 inhibitors |
| EP4499646A4 (en) * | 2022-03-31 | 2026-03-18 | Hangzhou Highlightll Pharmaceutical Co Ltd | NLRP3 Inflammasome Inhibitors |
| WO2024006559A1 (en) * | 2022-07-01 | 2024-01-04 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
| EP4554945A1 (en) * | 2022-07-14 | 2025-05-21 | AC Immune SA | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| CN120379995A (zh) * | 2022-12-27 | 2025-07-25 | 正大天晴药业集团股份有限公司 | 一种哒嗪稠芳环化合物及其用途 |
| WO2024157953A1 (ja) * | 2023-01-24 | 2024-08-02 | 第一三共株式会社 | 置換ベンゼン化合物 |
| CN120981462A (zh) * | 2023-01-31 | 2025-11-18 | 詹森药业有限公司 | 咪唑并[1,2-d][1,2,4]三嗪作为NLRP3抑制剂 |
| WO2024160694A1 (en) * | 2023-01-31 | 2024-08-08 | Janssen Pharmaceutica Nv | [1,2,4]TRIAZOLO[4,3-a]PYRIDINES AND [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS NLRP3 INHIBITORS |
| KR20250134147A (ko) | 2023-01-31 | 2025-09-09 | 얀센 파마슈티카 엔브이 | NLRP3 억제제로서의 피롤로[1,2-d][1,2,4]트리아진 및 피라졸로[1,5-d] [1,2,4]트리아진 |
| CN120659791A (zh) * | 2023-04-17 | 2025-09-16 | 上海拓界生物医药科技有限公司 | 稠合哒嗪类衍生物及其用途 |
| AU2024280075A1 (en) | 2023-06-02 | 2025-12-11 | Merck Sharp & Dohme Llc | 5,6-Unsaturated Bicyclic Heterocycles Useful as Inhibitors of Nod-Like Receptor Protein 3 |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003507479A (ja) * | 1999-08-23 | 2003-02-25 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体 |
| WO2018221433A1 (ja) * | 2017-05-29 | 2018-12-06 | 第一三共株式会社 | ヘテロアリールアミン誘導体 |
| WO2020234715A1 (en) * | 2019-05-17 | 2020-11-26 | Novartis Ag | Nlrp3 inflammasome inhibitors |
| WO2021009567A1 (en) * | 2019-07-17 | 2021-01-21 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| WO2023159148A2 (en) * | 2022-02-18 | 2023-08-24 | Ptc Therapeutics, Inc. | Inhibitors of nlrp3 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2868780B1 (fr) * | 2004-04-13 | 2008-10-17 | Sanofi Synthelabo | Derives de la 1-amino-phthalazine, leur preparation et leur application en therapeutique |
| EP1745039A4 (en) * | 2004-05-08 | 2009-07-22 | Neurogen Corp | 3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES |
-
2022
- 2022-06-28 US US18/574,530 patent/US20240327413A1/en active Pending
- 2022-06-28 EP EP22834059.2A patent/EP4362946A4/en active Pending
- 2022-06-28 WO PCT/US2022/035306 patent/WO2023278438A1/en not_active Ceased
- 2022-06-28 JP JP2023580379A patent/JP2024529839A/ja active Pending
- 2022-06-29 TW TW111124256A patent/TW202319054A/zh unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003507479A (ja) * | 1999-08-23 | 2003-02-25 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体リガンドとしてのイミダゾ−トリアジン誘導体 |
| WO2018221433A1 (ja) * | 2017-05-29 | 2018-12-06 | 第一三共株式会社 | ヘテロアリールアミン誘導体 |
| WO2020234715A1 (en) * | 2019-05-17 | 2020-11-26 | Novartis Ag | Nlrp3 inflammasome inhibitors |
| WO2021009567A1 (en) * | 2019-07-17 | 2021-01-21 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| WO2023159148A2 (en) * | 2022-02-18 | 2023-08-24 | Ptc Therapeutics, Inc. | Inhibitors of nlrp3 |
Non-Patent Citations (2)
| Title |
|---|
| GERLINDE FRENZEN, MONIKA RISCHKE UND GUNTHER SEITZ: "Thermisch induzierte formale [3 + 2]-Cycloadditionen von 3,3-Dimethoxycyclopropen an Triazine, eine", CHEMISCHE BERICHTE, vol. 126(10), JPN7026001549, October 1993 (1993-10-01), DE, pages 2317 - 2323, ISSN: 0005833067 * |
| ROLF PAUL, JOHN A. BROCKMAN, W. A. HALLETT, JOHN W. HANIFIN, M. ERNESTINE TARRANT, LAWRENCE W. TORLE: "Imidazo[1,5-d][1,2,4]triazines as Potential Antiasthma Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 28(11), JPN7026001550, 1 November 1985 (1985-11-01), US, pages 1704 - 1716, ISSN: 0005833068 * |
Also Published As
| Publication number | Publication date |
|---|---|
| TW202319054A (zh) | 2023-05-16 |
| WO2023278438A1 (en) | 2023-01-05 |
| EP4362946A1 (en) | 2024-05-08 |
| EP4362946A4 (en) | 2025-05-21 |
| US20240327413A1 (en) | 2024-10-03 |
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Legal Events
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