JP2024527345A - 改変東部ウマ脳炎ウイルス、自己複製ｒｎａ構築物、及びその使用 - Google Patents

改変東部ウマ脳炎ウイルス、自己複製ｒｎａ構築物、及びその使用 Download PDF

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JP2024527345A
JP2024527345A JP2024500069A JP2024500069A JP2024527345A JP 2024527345 A JP2024527345 A JP 2024527345A JP 2024500069 A JP2024500069 A JP 2024500069A JP 2024500069 A JP2024500069 A JP 2024500069A JP 2024527345 A JP2024527345 A JP 2024527345A
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nucleic acid
cells
cell
human
recombinant
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JP2024527345A5 (https=
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スティーブン ワン ナサニエル
ジョーセフ ミヤケ－ストーナー シゲキ
アリアマド パリナズ
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リプリケイト バイオサイエンス，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/5107—Excipients; Inactive ingredients
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K2039/53—DNA (RNA) vaccination
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    • C12N2770/36011—Togaviridae
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36151—Methods of production or purification of viral material

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JP2024500069A 2021-07-09 2022-07-08 改変東部ウマ脳炎ウイルス、自己複製ｒｎａ構築物、及びその使用 Pending JP2024527345A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163220139P 2021-07-09 2021-07-09
US63/220,139 2021-07-09
PCT/US2022/073563 WO2023283641A1 (en) 2021-07-09 2022-07-08 Modified eastern equine encephalitis viruses, self-replicating rna constructs, and uses thereof

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JP2024527345A true JP2024527345A (ja) 2024-07-24
JP2024527345A5 JP2024527345A5 (https=) 2025-07-15

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JP2024500069A Pending JP2024527345A (ja) 2021-07-09 2022-07-08 改変東部ウマ脳炎ウイルス、自己複製ｒｎａ構築物、及びその使用

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US (1) US20240327865A1 (https=)
EP (1) EP4367253A4 (https=)
JP (1) JP2024527345A (https=)
KR (1) KR20240032932A (https=)
CN (1) CN117897494A (https=)
AU (1) AU2022308056A1 (https=)
CA (1) CA3225064A1 (https=)
IL (1) IL309889A (https=)
WO (1) WO2023283641A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113966221B (zh) * 2019-03-08 2026-03-31 麻省理工学院 合成溶瘤lnp复制子rna和用于癌症免疫治疗的用途
AU2024279218A1 (en) * 2023-05-26 2026-01-15 Replicate Bioscience, Inc. Compositions and methods for expression of il-1ra and il-18bp

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102718353B1 (ko) * 2016-10-17 2024-10-15 얀센 파마슈티칼즈, 인코포레이티드 재조합 바이러스 레플리콘 시스템 및 그의 용도
WO2020076775A1 (en) * 2018-10-08 2020-04-16 Janssen Pharmaceuticals, Inc. Alphavirus-based replicons for administration of biotherapeutics

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AU2022308056A1 (en) 2024-02-01
CA3225064A1 (en) 2023-01-12
US20240327865A1 (en) 2024-10-03
CN117897494A (zh) 2024-04-16
IL309889A (en) 2024-03-01
WO2023283641A1 (en) 2023-01-12
EP4367253A4 (en) 2025-06-04
KR20240032932A (ko) 2024-03-12
EP4367253A1 (en) 2024-05-15

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