JP2024526324A - Ｂｃｍａ指向性細胞免疫療法の組成物および方法 - Google Patents

Ｂｃｍａ指向性細胞免疫療法の組成物および方法 Download PDF

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JP2024526324A
JP2024526324A JP2024501573A JP2024501573A JP2024526324A JP 2024526324 A JP2024526324 A JP 2024526324A JP 2024501573 A JP2024501573 A JP 2024501573A JP 2024501573 A JP2024501573 A JP 2024501573A JP 2024526324 A JP2024526324 A JP 2024526324A
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bcma
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JP2024526324A5 (https=
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ラクシュミ ラジャンガム，カンヤ
バーナビー トレイガー，ジェイムズ
ブーレン，ルシュアン グオ
グオ，チャオ
ライダ リアナ ラゼティック，アレクサンドラ
ラクシュマンバイ パテル，ニティンクマール
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Nkarta Inc
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Nkarta Inc
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4215—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/21—Transmembrane domain
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024501573A 2021-07-12 2022-07-08 Ｂｃｍａ指向性細胞免疫療法の組成物および方法 Pending JP2024526324A (ja)

Applications Claiming Priority (3)

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US202163220842P 2021-07-12 2021-07-12
US63/220,842 2021-07-12
PCT/US2022/073567 WO2023288185A2 (en) 2021-07-12 2022-07-08 Bcma-directed cellular immunotherapy compositions and methods

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JP2024526324A true JP2024526324A (ja) 2024-07-17
JP2024526324A5 JP2024526324A5 (https=) 2026-04-23

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US (1) US20250319185A1 (https=)
EP (1) EP4370554A4 (https=)
JP (1) JP2024526324A (https=)
KR (1) KR20240033025A (https=)
CN (1) CN117916267A (https=)
AU (1) AU2022310676A1 (https=)
CA (1) CA3224478A1 (https=)
IL (1) IL309436A (https=)
MX (1) MX2024000675A (https=)
WO (1) WO2023288185A2 (https=)

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Publication number Priority date Publication date Assignee Title
CN116355081A (zh) * 2023-02-01 2023-06-30 清华大学 一种广谱中和SARS-CoV-2的中和抗体P2-1D5及其应用
WO2024218688A1 (en) * 2023-04-18 2024-10-24 Board Of Regents, The University Of Texas System Bcma chimeric antigen receptors and uses thereof
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2026006767A1 (en) 2024-06-28 2026-01-02 Dispatch Biotherapeutics, Inc. Tethered il-9/il-9r and related engineered cells and methods
WO2026072671A1 (en) 2024-09-24 2026-04-02 City Of Hope Methods comprising oncolytic viruses expressing bcmat and bcma-targeted therapies

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CA2742969A1 (en) * 2008-11-07 2010-05-14 Fabrus Llc Anti-dll4 antibodies and uses thereof
MY191537A (en) * 2014-12-05 2022-06-30 Memorial Sloan Kettering Cancer Center Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
WO2019084057A2 (en) * 2017-10-24 2019-05-02 Magenta Therapeutics, Inc. COMPOSITIONS AND METHODS FOR DEPLOYING CD117 + CELLS
SMT202400408T1 (it) * 2019-01-16 2024-11-15 Caribou Biosciences Inc Anticorpo umanizzato bcma e cellule bcma-car-t

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IL309436A (en) 2024-02-01
CN117916267A (zh) 2024-04-19
US20250319185A1 (en) 2025-10-16
MX2024000675A (es) 2024-02-07
EP4370554A4 (en) 2026-01-07
KR20240033025A (ko) 2024-03-12
WO2023288185A2 (en) 2023-01-19
EP4370554A2 (en) 2024-05-22
WO2023288185A3 (en) 2023-02-23
CA3224478A1 (en) 2023-01-19
AU2022310676A1 (en) 2024-01-18

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