JP2024526305A - Ｌｒｒｋ２の野生型および変異体形態の分解剤ならびにその使用 - Google Patents

Ｌｒｒｋ２の野生型および変異体形態の分解剤ならびにその使用 Download PDF

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JP2024526305A
JP2024526305A JP2024500185A JP2024500185A JP2024526305A JP 2024526305 A JP2024526305 A JP 2024526305A JP 2024500185 A JP2024500185 A JP 2024500185A JP 2024500185 A JP2024500185 A JP 2024500185A JP 2024526305 A JP2024526305 A JP 2024526305A
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pharma
stereoisomer
acceptable salt
bifunctional compound
ceutically acceptable
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JP2024526305A5 (https=
Inventor
ナサナエル エス． グレイ，
ジョン ハッチャー，
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ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド
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Publication of JP2024526305A publication Critical patent/JP2024526305A/ja
Publication of JP2024526305A5 publication Critical patent/JP2024526305A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024500185A 2021-07-08 2022-07-07 Ｌｒｒｋ２の野生型および変異体形態の分解剤ならびにその使用 Pending JP2024526305A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163219629P 2021-07-08 2021-07-08
US63/219,629 2021-07-08
PCT/US2022/073517 WO2023283606A1 (en) 2021-07-08 2022-07-07 Degraders of wild-type and mutant forms of lrrk2 and uses thereof

Publications (2)

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JP2024526305A true JP2024526305A (ja) 2024-07-17
JP2024526305A5 JP2024526305A5 (https=) 2025-07-14

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JP2024500185A Pending JP2024526305A (ja) 2021-07-08 2022-07-07 Ｌｒｒｋ２の野生型および変異体形態の分解剤ならびにその使用

Country Status (6)

Country Link
US (1) US20240308982A1 (https=)
EP (1) EP4367115A4 (https=)
JP (1) JP2024526305A (https=)
AU (1) AU2022306049A1 (https=)
CA (1) CA3218951A1 (https=)
WO (1) WO2023283606A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024512501A (ja) 2021-03-19 2024-03-19 アルヴィナス・オペレーションズ・インコーポレイテッド インダゾール系化合物及び関連使用方法
TW202515874A (zh) 2023-09-28 2025-04-16 美商亞文納營運公司 用於靶向降解富含白胺酸之重複激酶２（ｌｒｒｋ２）的基於苯并咪唑及苯并咪唑酮之ｐｒｏｔａｃ化合物
WO2025201511A1 (zh) * 2024-03-29 2025-10-02 上海京新生物医药有限公司 吲唑衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081682A1 (en) * 2018-10-16 2020-04-23 Dana-Farber Cancer Institute, Inc. Degraders of wild-type and mutant forms of lrrk2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014134772A1 (en) * 2013-03-04 2014-09-12 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020081682A1 (en) * 2018-10-16 2020-04-23 Dana-Farber Cancer Institute, Inc. Degraders of wild-type and mutant forms of lrrk2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMMEDCHEM, vol. 16, JPN7026001133, December 2020 (2020-12-01), pages 959 - 965, ISSN: 0005822882 *

Also Published As

Publication number Publication date
CA3218951A1 (en) 2023-01-12
WO2023283606A1 (en) 2023-01-12
US20240308982A1 (en) 2024-09-19
EP4367115A4 (en) 2025-10-08
AU2022306049A1 (en) 2023-11-30
EP4367115A1 (en) 2024-05-15

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