JP2024524388A - Ｗｎｔファミリーメンバー５Ｂ（ＷＮＴ５Ｂ）阻害剤での低下した骨塩密度の処置 - Google Patents

Ｗｎｔファミリーメンバー５Ｂ（ＷＮＴ５Ｂ）阻害剤での低下した骨塩密度の処置 Download PDF

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JP2024524388A
JP2024524388A JP2023580537A JP2023580537A JP2024524388A JP 2024524388 A JP2024524388 A JP 2024524388A JP 2023580537 A JP2023580537 A JP 2023580537A JP 2023580537 A JP2023580537 A JP 2023580537A JP 2024524388 A JP2024524388 A JP 2024524388A
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seq
complement
position corresponding
adenine
positions
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JP2024524388A5 (https=
JP2024524388A6 (ja
Inventor
ボビン、ヨナス
ソシナ、オルカヨデ
アンドレア ロッタ、ルカ
バラス、アリス
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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Publication of JP2024524388A5 publication Critical patent/JP2024524388A5/ja
Publication of JP2024524388A6 publication Critical patent/JP2024524388A6/ja
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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JP2023580537A 2021-07-02 2022-06-30 Ｗｎｔファミリーメンバー５Ｂ（ＷＮＴ５Ｂ）阻害剤での低下した骨塩密度の処置 Pending JP2024524388A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163218209P 2021-07-02 2021-07-02
US63/218,209 2021-07-02
PCT/US2022/035846 WO2023278787A2 (en) 2021-07-02 2022-06-30 Treatment of decreased bone mineral density with wnt family member 5b (wnt5b) inhibitors

Publications (3)

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JP2024524388A true JP2024524388A (ja) 2024-07-05
JP2024524388A5 JP2024524388A5 (https=) 2025-07-07
JP2024524388A6 JP2024524388A6 (ja) 2025-08-08

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JP2023580537A Pending JP2024524388A (ja) 2021-07-02 2022-06-30 Ｗｎｔファミリーメンバー５Ｂ（ＷＮＴ５Ｂ）阻害剤での低下した骨塩密度の処置

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Country Link
US (1) US20230083558A1 (https=)
EP (1) EP4363586A2 (https=)
JP (1) JP2024524388A (https=)
KR (1) KR20240043753A (https=)
CN (1) CN117940565A (https=)
AU (1) AU2022302084A1 (https=)
CA (1) CA3225083A1 (https=)
IL (1) IL309644A (https=)
MX (1) MX2023015271A (https=)
WO (1) WO2023278787A2 (https=)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090047276A1 (en) * 2007-05-15 2009-02-19 University Of Washington Methods for increasing cell or tissue regeneration in a vertebrate subject
WO2017023973A1 (en) * 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof

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WO2023278787A3 (en) 2023-03-23
MX2023015271A (es) 2024-06-11
WO2023278787A9 (en) 2024-05-10
AU2022302084A1 (en) 2024-01-04
IL309644A (en) 2024-02-01
EP4363586A2 (en) 2024-05-08
KR20240043753A (ko) 2024-04-03
US20230083558A1 (en) 2023-03-16
WO2023278787A2 (en) 2023-01-05
CN117940565A (zh) 2024-04-26
CA3225083A1 (en) 2023-01-05

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