JP2024523730A - 天然のライアビリティを含まないｃｄｒを使用した抗体親和性成熟 - Google Patents

天然のライアビリティを含まないｃｄｒを使用した抗体親和性成熟 Download PDF

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Publication number
JP2024523730A
JP2024523730A JP2024501196A JP2024501196A JP2024523730A JP 2024523730 A JP2024523730 A JP 2024523730A JP 2024501196 A JP2024501196 A JP 2024501196A JP 2024501196 A JP2024501196 A JP 2024501196A JP 2024523730 A JP2024523730 A JP 2024523730A
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Japan
Prior art keywords
antibody
cdr sequences
sequence
cdr3
cdr1
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Pending
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JP2024501196A
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English (en)
Japanese (ja)
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JP2024523730A5 (https=
Inventor
レイモン モートン ブラッドバリー アンドリュー
ディアンジェロ サラ
テイシェイラ アンドレ
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ルールズ－ベースド メディシン インコーポレイティド
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Publication of JP2024523730A publication Critical patent/JP2024523730A/ja
Publication of JP2024523730A5 publication Critical patent/JP2024523730A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
JP2024501196A 2021-07-07 2022-07-07 天然のライアビリティを含まないｃｄｒを使用した抗体親和性成熟 Pending JP2024523730A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163218919P 2021-07-07 2021-07-07
US63/218,919 2021-07-07
PCT/US2022/036422 WO2023283383A1 (en) 2021-07-07 2022-07-07 Antibody affinity maturation using natural liability-free cdrs

Publications (2)

Publication Number Publication Date
JP2024523730A true JP2024523730A (ja) 2024-06-28
JP2024523730A5 JP2024523730A5 (https=) 2025-07-14

Family

ID=84801095

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024501196A Pending JP2024523730A (ja) 2021-07-07 2022-07-07 天然のライアビリティを含まないｃｄｒを使用した抗体親和性成熟

Country Status (6)

Country Link
US (2) US20230167165A1 (https=)
EP (1) EP4366773A4 (https=)
JP (1) JP2024523730A (https=)
KR (1) KR20240056488A (https=)
CN (1) CN118103065A (https=)
WO (1) WO2023283383A1 (https=)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877688B2 (en) * 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
EP3246434A1 (en) * 2015-01-13 2017-11-22 Ewha University-Industry Collaboration Foundation Method for preparing novel antibody library and library prepared thereby
EP3728705A4 (en) * 2017-12-18 2022-01-19 Charles River Laboratories, Inc. RADICALLY DIVERSE HUMAN ANTIBODY LIBRARY
EP3833685A4 (en) * 2018-07-08 2022-08-17 Specifica Inc. ANTIBODY LIBRARIES WITH FEATURES FOR MAXIMIZED ANTIBODY DEVELOPMENT

Also Published As

Publication number Publication date
US20230167165A1 (en) 2023-06-01
EP4366773A1 (en) 2024-05-15
WO2023283383A1 (en) 2023-01-12
CN118103065A (zh) 2024-05-28
EP4366773A4 (en) 2025-11-05
US20240384438A1 (en) 2024-11-21
KR20240056488A (ko) 2024-04-30

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