JP2024522642A - 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法 - Google Patents

高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法 Download PDF

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JP2024522642A
JP2024522642A JP2023576018A JP2023576018A JP2024522642A JP 2024522642 A JP2024522642 A JP 2024522642A JP 2023576018 A JP2023576018 A JP 2023576018A JP 2023576018 A JP2023576018 A JP 2023576018A JP 2024522642 A JP2024522642 A JP 2024522642A
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liver
gulo
protein
functional
organoids
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JP2024522642A5 (https=
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貴則 武部
レザ、ハッサン、アル
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Cincinnati Childrens Hospital Medical Center
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Cincinnati Childrens Hospital Medical Center
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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    • G01N33/5067—Liver cells
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JP2023576018A 2021-06-11 2022-06-10 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法 Pending JP2024522642A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163209908P 2021-06-11 2021-06-11
US63/209,908 2021-06-11
PCT/US2022/033066 WO2022261471A2 (en) 2021-06-11 2022-06-10 Liver organoid model for hyperbilirubinemia and methods of making and using same

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JP2024522642A true JP2024522642A (ja) 2024-06-21
JP2024522642A5 JP2024522642A5 (https=) 2025-06-23

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JP2023576018A Pending JP2024522642A (ja) 2021-06-11 2022-06-10 高ビリルビン血症のための肝臓オルガノイドモデル及びその作製方法及び使用方法

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US (1) US20240368556A1 (https=)
EP (1) EP4352206A4 (https=)
JP (1) JP2024522642A (https=)
WO (1) WO2022261471A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2024206911A2 (en) * 2023-03-30 2024-10-03 Children's Hospital Medical Center Clinical-grade organoids
WO2025231435A1 (en) * 2024-05-02 2025-11-06 R.P. Scherer Technologies, Llc Development of human hepatocyte differentiation and detection method using ipscs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3350313B1 (en) * 2015-09-15 2025-11-26 Agency For Science, Technology And Research (A*star) Derivation of liver organoids from human pluripotent stem cells
WO2018226267A1 (en) * 2017-06-09 2018-12-13 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3856204A4 (en) * 2018-09-27 2022-06-29 Children's Hospital Medical Center Liver support system comprising liver organoids and methods of making and using same
JP7556502B2 (ja) * 2019-05-09 2024-09-26 フジフィルム セルラー ダイナミクス，インコーポレイテッド ヘパトサイトの作製方法

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WO2022261471A2 (en) 2022-12-15
EP4352206A2 (en) 2024-04-17
EP4352206A4 (en) 2025-12-17
US20240368556A1 (en) 2024-11-07
WO2022261471A3 (en) 2023-03-02

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