JP2024521767A - Ｈ因子ファミリータンパク質のための阻害性核酸 - Google Patents

Ｈ因子ファミリータンパク質のための阻害性核酸 Download PDF

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JP2024521767A
JP2024521767A JP2023572717A JP2023572717A JP2024521767A JP 2024521767 A JP2024521767 A JP 2024521767A JP 2023572717 A JP2023572717 A JP 2023572717A JP 2023572717 A JP2023572717 A JP 2023572717A JP 2024521767 A JP2024521767 A JP 2024521767A
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nucleic acid
complement
nucleotide sequence
agent
fhr1
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JP2024521767A5 (OSRAM
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クラーク，サイモン
ムンエ，ムスタファ
ラティ，ソニカ
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コンプリメント・セラピューティクス・リミテッド
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2310/00—Structure or type of the nucleic acid
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JP2023572717A 2021-05-27 2022-05-26 Ｈ因子ファミリータンパク質のための阻害性核酸 Pending JP2024521767A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2107586.6A GB202107586D0 (en) 2021-05-27 2021-05-27 Inhibitory nucleic acids for Factor H family proteins
GB2107586.6 2021-05-27
PCT/EP2022/064376 WO2022248651A2 (en) 2021-05-27 2022-05-26 Inhibitory nucleic acids for factor h family proteins

Publications (2)

Publication Number Publication Date
JP2024521767A true JP2024521767A (ja) 2024-06-04
JP2024521767A5 JP2024521767A5 (OSRAM) 2025-06-03

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JP2023572717A Pending JP2024521767A (ja) 2021-05-27 2022-05-26 Ｈ因子ファミリータンパク質のための阻害性核酸

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Country Link
US (1) US20240209367A1 (OSRAM)
EP (1) EP4347030A2 (OSRAM)
JP (1) JP2024521767A (OSRAM)
CN (1) CN118632711A (OSRAM)
AU (1) AU2022279580A1 (OSRAM)
CA (1) CA3219247A1 (OSRAM)
GB (1) GB202107586D0 (OSRAM)
WO (1) WO2022248651A2 (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024165568A2 (en) * 2023-02-06 2024-08-15 E-Therapeutics Plc Inhibitors of expression and/or function

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790867B2 (en) * 2002-12-05 2010-09-07 Rosetta Genomics Inc. Vaccinia virus-related nucleic acids and microRNA
US20050118625A1 (en) * 2003-10-02 2005-06-02 Mounts William M. Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
EP1752536A4 (en) * 2004-05-11 2008-04-16 Alphagen Co Ltd POLYNUCLEOTIDE CAUSING RNA INTERFERENCE AND METHOD OF REGULATING GENE EXPRESSION WITH THE USE OF THE SAME
US8088579B2 (en) * 2005-02-14 2012-01-03 University Of Iowa Research Foundation Complement factor H for diagnosis of age-related macular degeneration
GB0611606D0 (en) * 2006-06-13 2006-07-19 Univ Belfast Protection against and treatment of age related macular degeneration
US20100324154A1 (en) 2007-11-01 2010-12-23 Hageman Gregory S Assessing susceptibility to vascular disorders
WO2012112955A2 (en) 2011-02-17 2012-08-23 The Trustees Of Columbia University In The City Of New York Methods for identifying subjects with a genetic risk for developing iga nephropathy
WO2013151192A1 (ko) 2012-04-02 2013-10-10 주식회사 성균바이오텍 등골나물속 추출물을 유효성분으로 하는 비만 및 골대사질환 예방 및 치료용 조성물
WO2013185069A1 (en) 2012-06-08 2013-12-12 Shire Human Genetic Therapies, Inc. Pulmonary delivery of mrna to non-lung target cells
SG10202104041PA (en) 2015-10-23 2021-06-29 Harvard College Nucleobase editors and uses thereof
GB201709222D0 (en) 2017-06-09 2017-07-26 Univ Manchester C3b Inactivating Polypeptide
US20200262879A1 (en) * 2017-09-11 2020-08-20 Insideoutbio, Inc. Methods and compositions to enhance the immunogenicity of tumors
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide
CN112470003A (zh) 2018-05-10 2021-03-09 曼彻斯特大学 评估黄斑变性的方法
WO2022058447A1 (en) * 2020-09-16 2022-03-24 The University Of Manchester Complementome assay

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GB202107586D0 (en) 2021-07-14
AU2022279580A1 (en) 2024-01-04
US20240209367A1 (en) 2024-06-27
WO2022248651A2 (en) 2022-12-01
CA3219247A1 (en) 2022-12-01
EP4347030A2 (en) 2024-04-10
CN118632711A (zh) 2024-09-10
WO2022248651A3 (en) 2023-02-02

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