JP2024520756A - ＡｐｏＥ及びＡｐｏＢ修飾脂質ナノ粒子組成物及びその使用 - Google Patents

ＡｐｏＥ及びＡｐｏＢ修飾脂質ナノ粒子組成物及びその使用 Download PDF

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JP2024520756A
JP2024520756A JP2023575397A JP2023575397A JP2024520756A JP 2024520756 A JP2024520756 A JP 2024520756A JP 2023575397 A JP2023575397 A JP 2023575397A JP 2023575397 A JP2023575397 A JP 2023575397A JP 2024520756 A JP2024520756 A JP 2024520756A
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pharmaceutical composition
lipid
peg
polypeptide
lnp
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JP2024520756A5 (enExample
Inventor
ミシェル ルブラン，
グレゴリー ファインスタイン，
ランドール ニュートン トイ，
バート ノルティング，
ナサニエル シルバー，
フィリップ サマヨア，
ジョン エドワード チャタートン，
マシュー マンガニエロ，
ダグラス エー． ローズ，
ライアン エム． デラニー，
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ジェネレーション バイオ カンパニー
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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JP2023575397A 2021-06-07 2022-06-07 ＡｐｏＥ及びＡｐｏＢ修飾脂質ナノ粒子組成物及びその使用 Pending JP2024520756A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163197881P 2021-06-07 2021-06-07
US63/197,881 2021-06-07
PCT/US2022/032510 WO2022261101A1 (en) 2021-06-07 2022-06-07 Apoe and apob modified lipid nanoparticle compositions and uses thereof

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JP2024520756A true JP2024520756A (ja) 2024-05-24
JP2024520756A5 JP2024520756A5 (enExample) 2025-06-17

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US (1) US20240299580A1 (enExample)
EP (1) EP4351533A4 (enExample)
JP (1) JP2024520756A (enExample)
KR (1) KR20240019244A (enExample)
CN (1) CN117897143A (enExample)
AU (1) AU2022288618A1 (enExample)
CA (1) CA3221454A1 (enExample)
IL (1) IL308928A (enExample)
WO (1) WO2022261101A1 (enExample)

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WO2024119103A1 (en) 2022-12-01 2024-06-06 Generation Bio Co. Lipid nanoparticles comprising nucleic acids and lipid-anchored polymers
EP4626400A1 (en) 2022-12-01 2025-10-08 Generation Bio Co. Novel polyglycerol-conjugated lipids and lipid nanoparticle compositions comprising the same
WO2024119074A1 (en) 2022-12-01 2024-06-06 Generation Bio Co. Stealth lipid nanoparticle compositions for cell targeting
AU2023406303A1 (en) 2022-12-01 2025-05-29 Generation Bio Co. Lipid nanoparticles comprising nucleic acids, ionizable lipids, sterols, lipid anchored polymers and helper lipids, their uses
US20240226133A1 (en) * 2023-01-09 2024-07-11 Claudia Chimisso Dos Santos Microrna-based particle for the treatment of dysregulated immune response
WO2024200820A1 (en) 2023-03-30 2024-10-03 Ose Immunotherapeutics Method of synthesis of targeted lipid nanoparticle and uses thereof
EP4687991A1 (en) 2023-03-30 2026-02-11 Ose Immunotherapeutics Lipid-based nanoparticle targeted at activated immune cells for the expression of immune cell enhancing molecule and use thereof
WO2024226779A1 (en) * 2023-04-26 2024-10-31 Saliogen Therapeutics, Inc. Lipid nanoparticle (lnp) formulations
IT202300015291A1 (it) * 2023-07-20 2025-01-20 Fond Riccardo Terzi E Silvio Albini Sistema di rilascio comprendente nanoparticelle lipidiche o polimeriche comprendenti ormoni tiroidei
WO2025052180A2 (en) 2023-09-07 2025-03-13 Axelyf ehf. Lipids and lipid nanoparticles
WO2025230906A1 (en) * 2024-04-29 2025-11-06 Saliogen Therapeutics, Inc. Lipid nanoparticle (lnp) formulations
WO2026003582A2 (en) 2024-06-27 2026-01-02 Axelyf ehf. Lipids and lipid nanoparticles
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