JP2024520674A - 薬物コンジュゲート及びその使用 - Google Patents

薬物コンジュゲート及びその使用 Download PDF

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JP2024520674A
JP2024520674A JP2023574472A JP2023574472A JP2024520674A JP 2024520674 A JP2024520674 A JP 2024520674A JP 2023574472 A JP2023574472 A JP 2023574472A JP 2023574472 A JP2023574472 A JP 2023574472A JP 2024520674 A JP2024520674 A JP 2024520674A
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iii
heterocyclyl
carbocyclyl
independently
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JP2024520674A5 (https=
Inventor
▲偉▼佳 ▲湯▼
▲しん▼ 周
星星 ▲梅▼
▲輝▼ ▲嚴▼
▲碩▼旭 李
建▲軍▼ 范
学康 ▲齊▼
金泉 ▲兪▼
▲勝▼峰 李
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バイオ－テラ ソリュ－ションズ，エルティーディー．
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Publication of JP2024520674A publication Critical patent/JP2024520674A/ja
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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