JP2024517871A - プロテアーゼ活性化治療剤を含む組成物および方法 - Google Patents

プロテアーゼ活性化治療剤を含む組成物および方法 Download PDF

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JP2024517871A
JP2024517871A JP2023568310A JP2023568310A JP2024517871A JP 2024517871 A JP2024517871 A JP 2024517871A JP 2023568310 A JP2023568310 A JP 2023568310A JP 2023568310 A JP2023568310 A JP 2023568310A JP 2024517871 A JP2024517871 A JP 2024517871A
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polypeptide
seq
aspects
linker
tumor
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JPWO2022236292A5 (https=
JP2024517871A5 (https=
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ジェフリー ハベル
純 石原
ジュアン メンドーサ
アスラン マンスロフ
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University of Chicago
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University of Chicago
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6843—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2023568310A 2021-05-07 2022-05-05 プロテアーゼ活性化治療剤を含む組成物および方法 Pending JP2024517871A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163185941P 2021-05-07 2021-05-07
US63/185,941 2021-05-07
US202263313087P 2022-02-23 2022-02-23
US63/313,087 2022-02-23
PCT/US2022/072121 WO2022236292A2 (en) 2021-05-07 2022-05-05 Compositions and methods comprising protease-activated therapeutic agents

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JP2024517871A true JP2024517871A (ja) 2024-04-23
JPWO2022236292A5 JPWO2022236292A5 (https=) 2025-05-15
JP2024517871A5 JP2024517871A5 (https=) 2025-05-15

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US (1) US20240228586A1 (https=)
EP (1) EP4333873A4 (https=)
JP (1) JP2024517871A (https=)
WO (1) WO2022236292A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022000991A (es) * 2019-07-25 2022-05-24 Univ Chicago Composiciones y metodos que comprenden agentes terapeuticos activados por proteasa.
BR112022012112A2 (pt) 2019-12-20 2022-09-06 Regeneron Pharma Agonistas de il2 e métodos de uso dos mesmos
TW202321282A (zh) 2021-07-19 2023-06-01 美商再生元醫藥公司 Il12受體促效劑及其使用方法
CR20250279A (es) * 2023-01-20 2025-08-25 Boehringer Ingelheim Int Proteínas de fusión fc de il-12
WO2025242835A1 (en) * 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer
WO2025242836A1 (en) * 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of auto-immune or inflammatory diseases and disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011517934A (ja) * 2008-03-03 2011-06-23 カンザス ステイト ユニバーシティ リサーチ ファウンデーション プロテアーゼアッセイ
TWI759810B (zh) * 2014-08-08 2022-04-01 美商Ａｌｘ腫瘤技術股份有限公司 信號調節蛋白α(signal-regulatory proteinα, SIRP-α)變體構築物及其用途
CA3100005A1 (en) * 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
MX2022000991A (es) * 2019-07-25 2022-05-24 Univ Chicago Composiciones y metodos que comprenden agentes terapeuticos activados por proteasa.
US20220356221A1 (en) * 2019-09-28 2022-11-10 AskGene Pharma, Inc. Cytokine prodrugs and dual-prodrugs

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WO2022236292A2 (en) 2022-11-10
EP4333873A2 (en) 2024-03-13
EP4333873A4 (en) 2025-08-06
WO2022236292A3 (en) 2022-12-15
US20240228586A1 (en) 2024-07-11

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