JP2024515714A - 散瞳、緑内障、及び他の眼の病態を治療するための方法及び組成物 - Google Patents

散瞳、緑内障、及び他の眼の病態を治療するための方法及び組成物 Download PDF

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JP2024515714A
JP2024515714A JP2023564598A JP2023564598A JP2024515714A JP 2024515714 A JP2024515714 A JP 2024515714A JP 2023564598 A JP2023564598 A JP 2023564598A JP 2023564598 A JP2023564598 A JP 2023564598A JP 2024515714 A JP2024515714 A JP 2024515714A
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patient
receptor agonist
dosage
acetylcholine receptor
eye
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JP2024515714A5 (enExample
Inventor
スチュアート ペポーズ，ジェイ
スチュアート レイザー，エリオット
スーチ，ミナ
アール マイヤー，アラン
チャリザニス，コンスタンティノス
ホフマン，バーンハート
エイチ ピトリック，ウィリアム
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Opus Genetics Inc
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Ocuphire Pharma Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/08—Mydriatics or cycloplegics
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2023564598A 2021-04-23 2022-04-22 散瞳、緑内障、及び他の眼の病態を治療するための方法及び組成物 Pending JP2024515714A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163178578P 2021-04-23 2021-04-23
US63/178,578 2021-04-23
PCT/US2022/025912 WO2022226286A1 (en) 2021-04-23 2022-04-22 Methods and compositions for treating mydriasis, glaucoma, and other ocular conditions

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JP2024515714A true JP2024515714A (ja) 2024-04-10
JP2024515714A5 JP2024515714A5 (enExample) 2025-04-30

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JP2023564598A Pending JP2024515714A (ja) 2021-04-23 2022-04-22 散瞳、緑内障、及び他の眼の病態を治療するための方法及び組成物

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US (1) US20240216334A1 (enExample)
EP (1) EP4326261A4 (enExample)
JP (1) JP2024515714A (enExample)
CN (1) CN117529316A (enExample)
AU (1) AU2022261123A1 (enExample)
CA (1) CA3216328A1 (enExample)
WO (1) WO2022226286A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3870170T3 (da) 2018-10-26 2026-05-26 Opus Genetics Inc Behandling af presbyopi og mydriasis med fentolamin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506967A (ja) * 2013-02-01 2016-03-07 オキュラリス・ファーマ・リミテッド・ライアビリティ・カンパニーＯｃｕｌａｒｉｓ Ｐｈａｒｍａ， Ｌｌｃ 視機能を改善するためのフェントラミンの連日眼科投与のための方法および組成物
WO2020087021A1 (en) * 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724558D0 (en) * 2007-12-15 2008-01-30 Sharma Anant Optical correction
JP2022508715A (ja) * 2018-10-15 2022-01-19 オキュフィア・ファーマ・インコーポレイテッド 緑内障および関連状態の処置のための方法および組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506967A (ja) * 2013-02-01 2016-03-07 オキュラリス・ファーマ・リミテッド・ライアビリティ・カンパニーＯｃｕｌａｒｉｓ Ｐｈａｒｍａ， Ｌｌｃ 視機能を改善するためのフェントラミンの連日眼科投与のための方法および組成物
WO2020087021A1 (en) * 2018-10-26 2020-04-30 Ocuphire Pharma, Inc. Methods and compositions for treatment of presbyopia, mydriasis, and other ocular disorders

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RETINA MED., vol. 8, no. 1, JPN6026022865, 2019, pages 98 - 99, ISSN: 0005880822 *

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AU2022261123A1 (en) 2023-11-16
CN117529316A (zh) 2024-02-06
EP4326261A1 (en) 2024-02-28
US20240216334A1 (en) 2024-07-04
WO2022226286A1 (en) 2022-10-27
CA3216328A1 (en) 2022-10-27
EP4326261A4 (en) 2025-05-21

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