JP2024515319A - 免疫調節因子を発現するcarベクター及びその応用 - Google Patents

免疫調節因子を発現するcarベクター及びその応用 Download PDF

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JP2024515319A
JP2024515319A JP2023566450A JP2023566450A JP2024515319A JP 2024515319 A JP2024515319 A JP 2024515319A JP 2023566450 A JP2023566450 A JP 2023566450A JP 2023566450 A JP2023566450 A JP 2023566450A JP 2024515319 A JP2024515319 A JP 2024515319A
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car
cells
tumor
csf
nucleic acid
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JP2024515319A5 (https=
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寒朔 ▲楊▼
▲チー▼▲チー▼ 李
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四川大学華西医院
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JP2023566450A 2021-04-30 2022-04-29 免疫調節因子を発現するcarベクター及びその応用 Pending JP2024515319A (ja)

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CN202110481979.9 2021-04-30
CN202110481979 2021-04-30
PCT/CN2022/090106 WO2022228538A1 (zh) 2021-04-30 2022-04-29 一种表达免疫调节因子的car载体及其应用

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JP2024515319A true JP2024515319A (ja) 2024-04-08
JP2024515319A5 JP2024515319A5 (https=) 2025-04-17

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US (1) US20240325442A1 (https=)
JP (1) JP2024515319A (https=)
CN (1) CN114934071B (https=)
AU (1) AU2022263746A1 (https=)
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WO (1) WO2022228538A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117986387A (zh) * 2023-05-31 2024-05-07 四川大学华西医院 一种新型小型化car设计及制备方法和应用
CN119144564B (zh) * 2023-11-24 2025-11-25 成都赛恩吉诺生物科技有限公司 表达GM-CSF的Ahelix功能区的免疫工程细胞及应用
CN119220499B (zh) * 2023-11-24 2025-11-25 成都赛恩吉诺生物科技有限公司 表达gm-csf的非连续截短功能区的免疫工程细胞及应用
CN119144565B (zh) * 2023-11-24 2025-11-25 成都赛恩吉诺生物科技有限公司 表达GM-CSF的exon 2功能区的免疫工程细胞及应用
CN119432754B (zh) * 2023-11-24 2025-10-10 成都赛恩吉诺生物科技有限公司 表达gm-csf的连续截短功能区的免疫工程细胞及应用
CN119144563B (zh) * 2023-11-24 2025-11-25 成都赛恩吉诺生物科技有限公司 表达gm-csf截短功能区片段的免疫工程细胞及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019232370A1 (en) * 2018-06-01 2019-12-05 Mayo Foundation For Medical Education And Research Materials and methods for treating cancer
WO2020106843A1 (en) * 2018-11-20 2020-05-28 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof
JP2021502828A (ja) * 2017-11-14 2021-02-04 メモリアル スローン ケタリング キャンサー センター Il−33を分泌する免疫応答性細胞およびその使用
JP2021502829A (ja) * 2017-11-14 2021-02-04 メモリアル スローン ケタリング キャンサー センター Il−36を分泌する免疫応答性細胞およびその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2828290B1 (en) * 2012-03-23 2018-08-15 The United States of America, represented by the Secretary, Department of Health and Human Services Anti-mesothelin chimeric antigen receptors
EP4166148B1 (en) * 2014-06-06 2026-02-18 Memorial Sloan-Kettering Cancer Center Mesothelin-targeted chimeric antigen receptors and uses thereof
IL315940A (en) * 2015-07-28 2024-11-01 Univ Pennsylvania Altered monocytes/macrophages expressing chimeric antigen receptors and their uses
CN105505869A (zh) * 2015-12-21 2016-04-20 河南大学淮河医院 一种针对肿瘤干细胞的嵌合抗原受体t细胞
US20180028631A1 (en) * 2016-07-29 2018-02-01 Lan Bo Chen Anti-ssea4 chimeric antigen receptors and their use for treating cancer
CN106543288A (zh) * 2016-10-24 2017-03-29 山东兴瑞生物科技有限公司 一种间皮素嵌合抗原受体修饰的t细胞制备及胰腺癌治疗上的应用
JP7296133B2 (ja) * 2018-03-16 2023-06-22 国立大学法人信州大学 遺伝子改変細胞及びその作製方法
CN110760001B (zh) * 2019-07-29 2023-03-24 浙江启新生物技术有限公司 Gm-csf敲低及其中和单链抗体分泌的嵌合抗原受体t细胞构建与应用
CN110396131B (zh) * 2019-08-23 2020-07-10 北京鼎成肽源生物技术有限公司 一种ErbB2单链抗体、靶向人ErbB2的嵌合抗原受体、重组载体、重组细胞和应用
CN110964121B (zh) * 2019-12-20 2022-09-16 山东省齐鲁细胞治疗工程技术有限公司 一种分泌il-7、il-15因子的cd19-car-t细胞及其应用
CN111944760A (zh) * 2020-08-14 2020-11-17 广东先康达生物科技有限公司 一种分泌双特异性抗体的免疫细胞及其应用
CN112210018A (zh) * 2020-10-12 2021-01-12 广东昭泰体内生物医药科技有限公司 一种靶向gpc3的嵌合抗原受体及其应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021502828A (ja) * 2017-11-14 2021-02-04 メモリアル スローン ケタリング キャンサー センター Il−33を分泌する免疫応答性細胞およびその使用
JP2021502829A (ja) * 2017-11-14 2021-02-04 メモリアル スローン ケタリング キャンサー センター Il−36を分泌する免疫応答性細胞およびその使用
WO2019232370A1 (en) * 2018-06-01 2019-12-05 Mayo Foundation For Medical Education And Research Materials and methods for treating cancer
WO2020106843A1 (en) * 2018-11-20 2020-05-28 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expressing therapeutic agent and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AVANZI, MAURO P. ET AL., CELL REPORTS, vol. 23, no. 7, JPN6026010404, 2018, pages 2130 - 2141, ISSN: 0005818168 *
STERNER, ROSALIE M. ET AL., BLOOD, vol. 133, no. 7, JPN6026010405, 2019, pages 697 - 709, ISSN: 0005818169 *

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