JP2024514026A - 哺乳類の樹状細胞の過剰活性化因子 - Google Patents

哺乳類の樹状細胞の過剰活性化因子 Download PDF

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Publication number
JP2024514026A
JP2024514026A JP2024506588A JP2024506588A JP2024514026A JP 2024514026 A JP2024514026 A JP 2024514026A JP 2024506588 A JP2024506588 A JP 2024506588A JP 2024506588 A JP2024506588 A JP 2024506588A JP 2024514026 A JP2024514026 A JP 2024514026A
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composition
lpc
acyl chain
agonist
cells
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JP2024514026A5 (enExample
Inventor
ケルシー ケー． フィン，
ジョナサン チャウ，
エミリー ゴセリン，
ダニア ジヴァキ，
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コーナー セラピューティクス， インコーポレイテッド
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Publication of JP2024514026A publication Critical patent/JP2024514026A/ja
Publication of JP2024514026A5 publication Critical patent/JP2024514026A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2024506588A 2021-04-12 2022-04-11 哺乳類の樹状細胞の過剰活性化因子 Pending JP2024514026A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163173958P 2021-04-12 2021-04-12
US63/173,958 2021-04-12
US202163246740P 2021-09-21 2021-09-21
US63/246,740 2021-09-21
PCT/US2022/071664 WO2022221827A2 (en) 2021-04-12 2022-04-11 Hyperactivators of mammalian dendritic cells

Publications (2)

Publication Number Publication Date
JP2024514026A true JP2024514026A (ja) 2024-03-27
JP2024514026A5 JP2024514026A5 (enExample) 2025-04-21

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JP2024506588A Pending JP2024514026A (ja) 2021-04-12 2022-04-11 哺乳類の樹状細胞の過剰活性化因子

Country Status (7)

Country Link
US (1) US20240197869A1 (enExample)
EP (1) EP4322999A2 (enExample)
JP (1) JP2024514026A (enExample)
AU (1) AU2022257111A1 (enExample)
CA (1) CA3215072A1 (enExample)
IL (1) IL307508A (enExample)
WO (1) WO2022221827A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118843455A (zh) * 2022-02-07 2024-10-25 科纳治疗公司 免疫原性mRNA递送媒介物
TW202342094A (zh) * 2022-02-07 2023-11-01 美商科納療法股份有限公司 高度活化之脂質奈米粒子
WO2024159157A2 (en) * 2023-01-27 2024-08-02 Corner Therapeutics, Inc. Phospholipid analogs for hyperactivation of mammalian dendritic cells
TW202502377A (zh) * 2023-03-13 2025-01-16 美商科納療法股份有限公司 旁觀者抗原增強之腫瘤細胞溶解物免疫原性
WO2025221606A1 (en) * 2024-04-16 2025-10-23 Corner Therapeutics, Inc. Lipids for hyperactivation of mammalian dendritic cells

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2836828A1 (fr) * 2002-03-11 2003-09-12 Bio Merieux Utilisation de l-alpha-lysophosphatidylcholine pour obtenir la differenciation de monocytes en cellules dendritiques matures in vitro
WO2004091603A1 (fr) * 2003-04-07 2004-10-28 Clinigenetics Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires
CN102293743B (zh) * 2010-06-24 2013-09-18 辽宁成大生物股份有限公司 一种脂质微球组合物
KR101951933B1 (ko) * 2013-03-12 2019-02-25 주식회사 아리바이오 라이소포스파티딜콜린 또는 이의 유도체를 포함하는 지질나노물질 및 이의 제조방법

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Publication number Publication date
EP4322999A2 (en) 2024-02-21
WO2022221827A3 (en) 2022-12-29
US20240197869A1 (en) 2024-06-20
AU2022257111A1 (en) 2023-10-26
CA3215072A1 (en) 2022-10-20
WO2022221827A2 (en) 2022-10-20
IL307508A (en) 2023-12-01

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