JP2024144435A5 - - Google Patents
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- Publication number
- JP2024144435A5 JP2024144435A5 JP2024111946A JP2024111946A JP2024144435A5 JP 2024144435 A5 JP2024144435 A5 JP 2024144435A5 JP 2024111946 A JP2024111946 A JP 2024111946A JP 2024111946 A JP2024111946 A JP 2024111946A JP 2024144435 A5 JP2024144435 A5 JP 2024144435A5
- Authority
- JP
- Japan
- Prior art keywords
- aav
- bioreactor
- genes encoding
- perfusion
- perfusion culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 13
- 230000010412 perfusion Effects 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 7
- 239000012737 fresh medium Substances 0.000 claims 4
- 239000012510 hollow fiber Substances 0.000 claims 3
- 239000002609 medium Substances 0.000 claims 3
- 241001655883 Adeno-associated virus - 1 Species 0.000 claims 2
- 101100524317 Adeno-associated virus 2 (isolate Srivastava/1982) Rep40 gene Proteins 0.000 claims 2
- 101100524319 Adeno-associated virus 2 (isolate Srivastava/1982) Rep52 gene Proteins 0.000 claims 2
- 101100524321 Adeno-associated virus 2 (isolate Srivastava/1982) Rep68 gene Proteins 0.000 claims 2
- 101100524324 Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 gene Proteins 0.000 claims 2
- 238000009295 crossflow filtration Methods 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims 1
- 241000202702 Adeno-associated virus - 3 Species 0.000 claims 1
- 241000580270 Adeno-associated virus - 4 Species 0.000 claims 1
- 241001634120 Adeno-associated virus - 5 Species 0.000 claims 1
- 241000972680 Adeno-associated virus - 6 Species 0.000 claims 1
- 241001164823 Adeno-associated virus - 7 Species 0.000 claims 1
- 241001164825 Adeno-associated virus - 8 Species 0.000 claims 1
- 241000649045 Adeno-associated virus 10 Species 0.000 claims 1
- 241000649046 Adeno-associated virus 11 Species 0.000 claims 1
- 241000702421 Dependoparvovirus Species 0.000 claims 1
- 101710103669 Protein Rep40 Proteins 0.000 claims 1
- 101710103623 Protein Rep52 Proteins 0.000 claims 1
- 101710103636 Protein Rep68 Proteins 0.000 claims 1
- 101710103500 Protein Rep78 Proteins 0.000 claims 1
- 108091034131 VA RNA Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000005484 gravity Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000012465 retentate Substances 0.000 claims 1
- 230000010415 tropism Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20209811.7 | 2020-11-25 | ||
| EP20209811.7A EP4006141A1 (en) | 2020-11-25 | 2020-11-25 | Method for the production of aav |
| JP2022569478A JP7601339B2 (ja) | 2020-11-25 | 2021-11-23 | Ａａｖを産生する方法 |
| PCT/EP2021/082615 WO2022112218A1 (en) | 2020-11-25 | 2021-11-23 | Method for the production of aav |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022569478A Division JP7601339B2 (ja) | 2020-11-25 | 2021-11-23 | Ａａｖを産生する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024144435A JP2024144435A (ja) | 2024-10-11 |
| JP2024144435A5 true JP2024144435A5 (enExample) | 2025-04-02 |
Family
ID=73597941
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022569478A Active JP7601339B2 (ja) | 2020-11-25 | 2021-11-23 | Ａａｖを産生する方法 |
| JP2024111946A Pending JP2024144435A (ja) | 2020-11-25 | 2024-07-11 | Ａａｖを産生する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022569478A Active JP7601339B2 (ja) | 2020-11-25 | 2021-11-23 | Ａａｖを産生する方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20240263148A1 (enExample) |
| EP (3) | EP4006141A1 (enExample) |
| JP (2) | JP7601339B2 (enExample) |
| KR (1) | KR102700433B1 (enExample) |
| CN (1) | CN116209748A (enExample) |
| AU (1) | AU2021388811B2 (enExample) |
| CA (1) | CA3174017C (enExample) |
| DK (1) | DK4107252T3 (enExample) |
| ES (1) | ES3017247T3 (enExample) |
| FI (1) | FI4107252T3 (enExample) |
| IL (1) | IL296770B2 (enExample) |
| MX (1) | MX2022013385A (enExample) |
| PT (1) | PT4107252T (enExample) |
| WO (1) | WO2022112218A1 (enExample) |
| ZA (1) | ZA202210745B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022373653A1 (en) | 2021-10-18 | 2024-05-02 | Regeneron Pharmaceuticals, Inc. | Eukaryotic cells comprising adenovirus-associated virus polynucleotides |
| JP2025509328A (ja) * | 2022-03-07 | 2025-04-11 | ウルトラジェニックス ファーマシューティカル インコーポレイテッド | 改良されたバッチａａｖ産生システムおよび方法 |
| CN119301260A (zh) * | 2022-06-03 | 2025-01-10 | 豪夫迈·罗氏有限公司 | 用于生产重组aav颗粒的方法 |
| WO2025047766A1 (ja) * | 2023-08-29 | 2025-03-06 | 富士フイルム株式会社 | ウイルスの製造方法および細胞への核酸導入方法 |
| WO2025171001A1 (en) | 2024-02-06 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for improved production of aav viral vectors |
| WO2025168663A1 (en) | 2024-02-09 | 2025-08-14 | F. Hoffmann-La Roche Ag | Method for producing recombinant adeno-associated viral particles |
| EP4606816A1 (en) * | 2024-02-26 | 2025-08-27 | Universitat Autónoma De Barcelona (UAB) | Method for production of gene therapy vehicles in mammalian cells |
| WO2025226558A1 (en) | 2024-04-22 | 2025-10-30 | Ultragenyx Pharmaceutical Inc. | Multi-step filtration and clarification methods for recombinant adeno-associated virus purification |
| WO2025252480A1 (en) | 2024-06-07 | 2025-12-11 | F. Hoffmann-La Roche Ag | Method for purifying plasmid dna |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020168342A1 (en) * | 1994-11-03 | 2002-11-14 | Cell Genesys, Inc. | Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods |
| US6995006B2 (en) * | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| EP1124976A1 (en) * | 1998-10-27 | 2001-08-22 | Crucell Holland B.V. | Improved aav vector production |
| US6844192B2 (en) * | 2001-06-29 | 2005-01-18 | Wake Forest University | Adenovirus E4 protein variants for virus production |
| EP3442688A4 (en) * | 2016-04-12 | 2019-11-20 | Artemis Biosystems, Inc. | FILTRATION SYSTEMS FOR INFUSION |
| EP3456822A1 (en) * | 2017-09-19 | 2019-03-20 | CEVEC Pharmaceuticals GmbH | Inducible aav rep genes |
| EP3914696A4 (en) * | 2019-01-25 | 2022-12-14 | Biogen MA Inc. | SEED CULTIVATION METHOD FOR THE PRODUCTION OF AAV |
| EP3962536A1 (en) * | 2019-04-29 | 2022-03-09 | Voyager Therapeutics, Inc. | Systems and methods for producing baculoviral infected insect cells (biics) in bioreactors |
-
2020
- 2020-11-25 EP EP20209811.7A patent/EP4006141A1/en not_active Withdrawn
-
2021
- 2021-11-23 EP EP25158433.0A patent/EP4596674A3/en active Pending
- 2021-11-23 CA CA3174017A patent/CA3174017C/en active Active
- 2021-11-23 IL IL296770A patent/IL296770B2/en unknown
- 2021-11-23 WO PCT/EP2021/082615 patent/WO2022112218A1/en not_active Ceased
- 2021-11-23 AU AU2021388811A patent/AU2021388811B2/en active Active
- 2021-11-23 DK DK21811385.0T patent/DK4107252T3/da active
- 2021-11-23 JP JP2022569478A patent/JP7601339B2/ja active Active
- 2021-11-23 CN CN202180045906.3A patent/CN116209748A/zh active Pending
- 2021-11-23 PT PT218113850T patent/PT4107252T/pt unknown
- 2021-11-23 FI FIEP21811385.0T patent/FI4107252T3/fi active
- 2021-11-23 MX MX2022013385A patent/MX2022013385A/es unknown
- 2021-11-23 US US18/005,027 patent/US20240263148A1/en active Pending
- 2021-11-23 KR KR1020227040149A patent/KR102700433B1/ko active Active
- 2021-11-23 EP EP21811385.0A patent/EP4107252B1/en active Active
- 2021-11-23 ES ES21811385T patent/ES3017247T3/es active Active
-
2022
- 2022-09-28 ZA ZA2022/10745A patent/ZA202210745B/en unknown
-
2024
- 2024-07-11 JP JP2024111946A patent/JP2024144435A/ja active Pending
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