JP2024060626A - Aqueous composition for external use and composition for producing ozone water - Google Patents
Aqueous composition for external use and composition for producing ozone water Download PDFInfo
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- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 title claims abstract description 80
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 53
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 239000006210 lotion Substances 0.000 claims description 5
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 17
- 239000004615 ingredient Substances 0.000 abstract description 8
- 238000000034 method Methods 0.000 description 8
- 230000003020 moisturizing effect Effects 0.000 description 7
- 239000000645 desinfectant Substances 0.000 description 5
- 238000005868 electrolysis reaction Methods 0.000 description 5
- 230000000699 topical effect Effects 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 238000011978 dissolution method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229940023579 anhydrous betaine Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
【課題】オゾンによる殺菌作用に加え、追加された外用成分の作用も十分に奏する外用水系組成物を提供する。【解決手段】皮膚塗布用水性組成物が、水と、オゾンと、トリメチルグリシンとを含む。【選択図】なし[Problem] To provide an aqueous composition for external application that satisfactorily exerts the action of added external ingredients in addition to the bactericidal action of ozone. [Solution] The aqueous composition for application to the skin contains water, ozone, and trimethylglycine. [Selected Figures] None
Description
本発明は、外用水系組成物、及びオゾン水製造用組成物に関する。 The present invention relates to an aqueous composition for external use and a composition for producing ozone water.
オゾンを水に溶かしてなるオゾン水は、殺菌作用に優れ、また取り扱いが容易なことから、医療、美容、食品、畜産、半導体等の様々な分野において利用されている。中でも、人体の皮膚表面の殺菌、消毒を目的としたオゾン水の利用が進められており、特にオゾン水を手指消毒用、手洗い用として使用することが知られている（特許文献１、２）。 Ozone water, which is made by dissolving ozone in water, has excellent bactericidal properties and is easy to handle, so it is used in a variety of fields, including medicine, beauty, food, livestock, and semiconductors. In particular, the use of ozone water for the purpose of sterilizing and disinfecting the surface of human skin is being promoted, and it is particularly known that ozone water is used for hand disinfection and hand washing (Patent Documents 1 and 2).
さらに近年、オゾン水を、皮膚等に塗布して使用する外用剤として利用することについての検討も進められている。すなわち、オゾン水に、追加的な効能を有する外用成分（例えば保湿成分等）を添加してなる水系組成物の開発が進められている。しかしながら、オゾン水に、オゾン以外の別の外用成分を添加した場合、当該外用成分がオゾンによって分解されてしまい、その効能を全く発揮できないか又は十分に発揮できない。 In recent years, further research has been conducted into the use of ozone water as an external preparation that is applied to the skin, etc. In other words, development of aqueous compositions in which external components with additional efficacy (e.g., moisturizing components, etc.) are added to ozone water is underway. However, when an external component other than ozone is added to ozone water, the external component is decomposed by the ozone, and the efficacy of the external component cannot be exerted at all or cannot be exerted sufficiently.
上記の点に鑑みて、本発明の一態様は、オゾンによる殺菌作用に加え、追加された外用成分の作用も十分に奏する外用水系組成物を提供することを課題とする。 In view of the above, one aspect of the present invention aims to provide an aqueous composition for external use that fully exerts the effects of added external ingredients in addition to the bactericidal effect of ozone.
上記課題を解決するための本発明の一態様は、外用水系組成物が、水と、オゾンと、トリメチルグリシンとを含む。 In one aspect of the present invention to solve the above problem, the aqueous composition for external use contains water, ozone, and trimethylglycine.
本発明の一態様によれば、オゾンによる殺菌作用に加え、追加された外用成分の作用も十分に奏する外用水系組成物を提供できる。 According to one aspect of the present invention, it is possible to provide an aqueous composition for external use that fully exerts the effects of added external ingredients in addition to the bactericidal action of ozone.
本実施形態による組成物は、外用組成物、すなわち、人や動物の皮膚、毛髪、粘膜等に塗布して利用される組成物であり、特に皮膚に塗布して利用される皮膚塗布用組成物として好適に使用される。また、本形態による組成物は、水系組成物、すなわち水をベースにした組成物である。例えば、本形態による組成物中に含まれる水の割合が、組成物の全量に対して８０質量％以上、好ましくは９０質量％以上、より好ましくは９５質量％以上となり得る。 The composition according to this embodiment is a composition for external use, i.e., a composition to be applied to the skin, hair, mucous membranes, etc. of humans or animals, and is particularly suitable for use as a composition for application to the skin. The composition according to this embodiment is also an aqueous composition, i.e., a composition based on water. For example, the proportion of water contained in the composition according to this embodiment can be 80% by mass or more, preferably 90% by mass or more, and more preferably 95% by mass or more, based on the total amount of the composition.
本形態による外用水系組成物は液体状態であることが好ましい。組成物が粘性を有していてもよいが、その粘性は噴霧可能な程度の低いものであると好ましい。例えば、外用水系組成物の粘度は、３０℃で測定した値で１００ｍＰａ・ｓ以下が好ましい。であってよい。 The aqueous composition for external use according to this embodiment is preferably in a liquid state. The composition may have viscosity, but the viscosity is preferably low enough to be sprayable. For example, the viscosity of the aqueous composition for external use is preferably 100 mPa·s or less as measured at 30°C.
本形態による外用水系組成物は、オゾンによって酸化又は変性された物質の殺菌作用を利用するものではなく、オゾン自体の殺菌作用を利用するものである。そのため、組成物中のオゾンの含有量をそれほど大きくせずとも、高い殺菌作用を供することができる。なお、本明細書において、「殺菌」とは、細菌、ウイルス等の微生物を死滅させたり、減らしたり、或いは弱体化若しくは不活性化させたりすることを指す。本明細書における「殺菌作用」には、除菌、滅菌、消毒等の概念も含まれるものとする。 The aqueous composition for external use according to this embodiment does not utilize the bactericidal action of a substance oxidized or denatured by ozone, but utilizes the bactericidal action of ozone itself. Therefore, a high bactericidal action can be provided without a large amount of ozone in the composition. In this specification, "bactericidal action" refers to the killing, reducing, weakening, or inactivating of microorganisms such as bacteria and viruses. In this specification, "bactericidal action" also includes concepts such as elimination, sterilization, and disinfection.
本形態による外用水系組成物におけるオゾンの濃度は、外用水系組成物の全量に対し、質量基準で、好ましくは１ｍｇ／Ｌ以上、より好ましくは２ｍｇ／Ｌ以上であってよい。オゾン濃度が１ｍｇ／Ｌ以上であることで、微生物に対する殺菌作用が十分に得られる。一方、外用水系組成物中のオゾン濃度の上限は、オゾンの生成方法にもよるが、水に対するオゾンの溶解度に照らすと、外用水系組成物の全量に対して質量比で１０ｍｇ／Ｌ以下であると好ましい。また、上記上限のオゾン濃度であると、人体又は動物に対する確実な安全性が得られる。 The ozone concentration in the aqueous composition for external use according to this embodiment may be, on a mass basis, preferably 1 mg/L or more, more preferably 2 mg/L or more, based on the total amount of the aqueous composition for external use. When the ozone concentration is 1 mg/L or more, a sufficient bactericidal effect against microorganisms is obtained. On the other hand, the upper limit of the ozone concentration in the aqueous composition for external use is preferably 10 mg/L or less based on the mass ratio to the total amount of the aqueous composition for external use, although this depends on the method for generating ozone. In addition, the above upper limit of the ozone concentration ensures safety to humans and animals.
外用水系組成物中のオゾンは、電解法（水の電気分解によるオゾン生成方法）により水中で生成されたものであってよいし、或いは放電法、紫外線ランプ法等によって空気中でオゾンガスを生成し、そのオゾンガスを水又は水系液中に溶解させたものであってもよい。オゾンガスを水又は水系液中に溶解させるための方法は、気泡溶解法、隔膜溶解法、充填層溶解法等であってよく、特に限定されない。このうち、小型の簡便な装置でオゾン生成を行うことができるため、電解法を用いることが好ましい。なお、上記のいずれのオゾン生成方法であっても、オゾン又はオゾン水を発生させる機器は、公知のものを用いることができる。 The ozone in the aqueous composition for external use may be generated in water by electrolysis (a method for generating ozone by electrolysis of water), or may be generated in air by discharge, ultraviolet lamp, or the like, and the ozone gas is dissolved in water or an aqueous liquid. The method for dissolving ozone gas in water or an aqueous liquid is not particularly limited and may be a bubble dissolution method, a diaphragm dissolution method, a packed bed dissolution method, or the like. Of these, it is preferable to use the electrolysis method, since ozone can be generated using a small, simple device. In any of the above ozone generation methods, a known device for generating ozone or ozone water can be used.
本形態による外用水系組成物は、上記のオゾンと共に、トリメチルグリシン（ＴＭＧ）を含有するものである。トリメチルグリシンは、グリシンベタイン、ベタイン、又は無水ベタインと称される成分である。トリメチルグリシンの作用は、主として保湿作用（塗布した対象からの水分の蒸発を防止する作用）である（特許第３５７７１１３号等）。よって、皮膚や毛髪に塗布した場合、皮膚や毛髪の状態を改善することができる。例えば、皮膚に対しては、水分の消失を防止することで皮膚にハリや弾力を与えることができるし、毛髪に対してはツヤを与え、またダメージを防ぐことができる。また、このようなアミノ酸系保湿成分は、安全性が高く、取り扱いも容易であり、帯電防止作用等も有する。 The aqueous composition for external use according to this embodiment contains trimethylglycine (TMG) in addition to the ozone described above. Trimethylglycine is a component known as glycine betaine, betaine, or anhydrous betaine. The main function of trimethylglycine is to moisturize (prevent water from evaporating from the subject to which it is applied) (Patent No. 3577113, etc.). Therefore, when applied to skin or hair, it can improve the condition of the skin or hair. For example, it can give firmness and elasticity to the skin by preventing water loss, and it can give shine to hair and prevent damage. In addition, such amino acid-based moisturizing components are highly safe, easy to handle, and have antistatic properties.
従来、オゾンとオゾン以外の別成分とを配合してなり、且つオゾン及び別成分が十分な機能を発揮できる水系組成物を提供することは、技術的に困難であった。オゾンは酸化力が高いため、併用される別成分がオゾンによって分解され、当該別成分の機能が低下又は消失してしまうと考えられていたからである。この場合、別成分の分解反応によってオゾン自体も還元され、その機能が低下するか又は消失してしまうので、結果として、オゾンも別成分も機能を十分に発揮することができなかった。これに対し、本発明者らは、水中でオゾンとトリメチルグリシンとが共存可能であることを見出し、本発明に至った。よって、本発明の形態によれば、オゾン及びトリメチルグリシンがそれぞれの機能を十分に発揮できる水系組成物を提供できる。より具体的には、オゾンの殺菌作用と、トリメチルグリシンの保湿等の作用とがそれぞれ十分に発揮される水系組成物を提供できる。 In the past, it was technically difficult to provide an aqueous composition that contains ozone and another component other than ozone and that allows the ozone and the other component to fully exert their functions. This is because it was thought that the other component used in combination would be decomposed by ozone due to its high oxidizing power, and the function of the other component would be reduced or lost. In this case, the decomposition reaction of the other component would reduce ozone itself, and its function would be reduced or lost, so that neither ozone nor the other component could fully exert their functions. In response to this, the present inventors discovered that ozone and trimethylglycine can coexist in water, leading to the present invention. Thus, according to the embodiment of the present invention, an aqueous composition can be provided in which ozone and trimethylglycine can fully exert their respective functions. More specifically, an aqueous composition can be provided in which the bactericidal action of ozone and the moisturizing action of trimethylglycine are each fully exerted.
外用水系組成物中のトリメチルグリシンの含有量は、外用水系組成物の全量に対し、好ましくは０．０１質量％以上１０質量％以下、より好ましくは０．１質量％以上５質量％以下であってよい。トリメチルグリシンの含有量が０．０１質量％以上であることで、保湿効果を高めることができ、また１０質量％以下であることで、外用水系組成物の使用触感を良好にできる、すなわちべたつきを抑えた心地良い使用感を付与できる。 The content of trimethylglycine in the aqueous composition for external use may be preferably 0.01% by mass or more and 10% by mass or less, more preferably 0.1% by mass or more and 5% by mass or less, based on the total amount of the aqueous composition for external use. A trimethylglycine content of 0.01% by mass or more can enhance the moisturizing effect, and a trimethylglycine content of 10% by mass or less can improve the feel of the aqueous composition when used, i.e., provide a comfortable feel with reduced stickiness.
なお、トリメチルグリシンとしては、例えば、旭化成ケミカルズ社製「アミノコート（登録商標）」、Ｅｖｏｎｉｋ社製「ＴＥＧＯ（登録商標）Ｎａｔｕｒａｌ Ｂｅｔａｉｎｅ」等の市販品を使用することもできる。 As trimethylglycine, commercially available products such as "Aminocoat (registered trademark)" manufactured by Asahi Kasei Chemicals Corporation and "TEGO (registered trademark) Natural Betaine" manufactured by Evonik Corporation can also be used.
外用水系組成物において、オゾンの含有量（ｗＯ）に対するトリメチルグリシンの含有量（ｗｔ）の比の値（ｗｔ／ｗＯ）は、質量比で、好ましくは１０以上１００，０００以下、より好ましくは１００以上１０，０００以下であってよい。比の値（ｗｔ／ｗＯ）が上記範囲であることで、殺菌作用及びトリメチルグリシンが機能をそれぞれ十分に発揮できる外用水系組成物が得られる。 In the aqueous composition for external use, the ratio ( wt / wO ) of the content of trimethylglycine ( wt ) to the content of ozone ( wO ), in terms of mass ratio, may be preferably from 10 to 100,000, more preferably from 100 to 10,000. When the ratio ( wt / wO ) is within the above range, an aqueous composition for external use can be obtained in which the bactericidal action and the function of trimethylglycine can be fully exerted.
外用水系組成物は、その機能を阻害しない量で、オゾン及びトリメチルグリシン以外の成分、より具体的には無機化合物を添加することも可能である。無機化合物としては、塩、鉱物、顔料等が挙げられる。 The aqueous composition for external use may contain components other than ozone and trimethylglycine, more specifically inorganic compounds, in amounts that do not impair the function of the composition. Examples of inorganic compounds include salts, minerals, pigments, etc.
本発明の一実施形態は、外用水系組成物の製造方法であって、オゾン水を生成し、当該オゾン水にトリメチルグリシンを添加することを含む方法であってよい。或いは、別の製造方法は、水にトリメチルグリシンを溶解させてトリメチルグリシン水溶液を調製し、当該トリメチルグリシン水溶液中に、予め空気中で生成させたオゾンを溶解させることを含む方法であってよい。また、水にトリメチルグリシンを溶解させてトリメチルグリシン水溶液を調製し、当該トリメチルグリシン水溶液中の水を原料としてオゾンを生成することを含む方法であってもよい。水を原料としたオゾンの生成には、上述の電解法等を用いることができる。 One embodiment of the present invention may be a method for producing an aqueous composition for external use, which may include generating ozone water and adding trimethylglycine to the ozone water. Alternatively, another production method may include dissolving trimethylglycine in water to prepare an aqueous trimethylglycine solution, and dissolving ozone previously generated in the air in the aqueous trimethylglycine solution. Alternatively, the method may include dissolving trimethylglycine in water to prepare an aqueous trimethylglycine solution, and generating ozone using the water in the aqueous trimethylglycine solution as a raw material. The above-mentioned electrolysis method or the like may be used to generate ozone using water as a raw material.
本形態による外用水系組成物は、化粧料、衛生日用品（パーソナルケア製品）、医薬部外品として好適に利用できる。例えば、殺菌作用のある化粧水、美容液、ボディーローション、ハンドローション、ヘアローション、として使用できる。 The aqueous composition for external use according to this embodiment can be suitably used as a cosmetic, a daily hygiene product (personal care product), or a quasi-drug. For example, it can be used as a bactericidal lotion, beauty essence, body lotion, hand lotion, or hair lotion.
外用水系組成物を使用する際には、使用者は、組成物を手に取って、塗布対象、例えば手指、顔、身体等の皮膚、毛髪に塗布したり、擦り込んだりすることができる。上記の塗布又は擦り込みのために、組成物はコットン、シート、刷毛等を利用することもできる。また、外用水系組成物を、噴霧器を備えた容器に収容しておき、使用時に対象の表面に噴霧することができる。或いは、シートを外用水系組成物に含侵させてなる、組成物含侵シートを予め製作して密閉容器等に保管しておき、使用者は、使用時にそのシートを取り出して使用することができる。 When using the aqueous composition for external use, the user can take the composition in his/her hands and apply or rub it into the skin or hair of the target, such as the hands, fingers, face, body, etc. For the above-mentioned application or rubbing, the composition can be used with cotton, a sheet, a brush, etc. Also, the aqueous composition for external use can be stored in a container equipped with a sprayer, and sprayed onto the surface of the target when used. Alternatively, a composition-impregnated sheet, which is a sheet impregnated with the aqueous composition for external use, can be produced in advance and stored in a sealed container, etc., and the user can remove the sheet when used.
なお、本形態による外用水系組成物は、保湿作用、帯電防止作用のある殺菌剤としても利用できる。言わば、高保湿性殺菌剤若しくは消毒剤、又は帯電防止性殺菌剤若しくは消毒剤として利用できる。より具体的には、様々な産業又は家庭における手洗い剤、手指消毒剤として利用することで、高い保湿効果を得ることができる。本形態による外用水系組成物を用いた手指消毒剤は、殺菌成分としてオゾンを利用するため、アルコールを用いた従来の手指消毒剤に比べて手荒れしにくいが、さらにトリメチルグリシンを含むことによって手荒れ防止の効果が一層高められ、使用後も皮膚が保湿された状態を持続させることができる。 The aqueous composition for external use according to this embodiment can also be used as a bactericide with moisturizing and antistatic properties. In other words, it can be used as a highly moisturizing bactericide or disinfectant, or an antistatic bactericide or disinfectant. More specifically, it can be used as a hand washing agent or hand disinfectant in various industries or at home, thereby achieving a high moisturizing effect. A hand disinfectant using the aqueous composition for external use according to this embodiment uses ozone as a bactericidal component, so it is less likely to cause rough hands compared to conventional hand disinfectants that use alcohol, but the inclusion of trimethylglycine further enhances the effect of preventing rough hands, and the skin can be kept moisturized even after use.
また、本発明の別の実施形態は、水と、トリメチルグリシンとを含む、オゾン水製造用組成物であってよい。水とトリメチルグリシンとを含む当該組成物は、オゾン水、より具体的にはオゾンによる作用以外の作用が追加されたオゾン水を製造するために使用することができる。その場合、水とトリメチルグリシンとを含む本形態による組成物を、オゾン水と混合するか、或いは、水とトリメチルグリシンとを含む本形態による組成物中に、電解法オゾン生成装置を挿入する等により、当該組成物に含まれる水からオゾンを生成させることができる。 Another embodiment of the present invention may be a composition for producing ozone water, containing water and trimethylglycine. The composition containing water and trimethylglycine can be used to produce ozone water, more specifically, ozone water to which an action other than that of ozone is added. In this case, ozone can be generated from the water contained in the composition by mixing the composition according to this embodiment containing water and trimethylglycine with ozone water, or by inserting an electrolysis ozone generator into the composition according to this embodiment containing water and trimethylglycine.
上記オゾン水製造用組成物において、トリメチルグリシンの含有量は、オゾン水製造用組成物の全量に対し、好ましくは０．０１質量％以上１０質量％以下、より好ましくは０．１質量％以上５質量％以下であってよい。 In the above-mentioned composition for producing ozone water, the content of trimethylglycine may be preferably 0.01% by mass or more and 10% by mass or less, more preferably 0.1% by mass or more and 5% by mass or less, based on the total amount of the composition for producing ozone water.
本発明のさらに別の実施形態は、上記オゾン水製造用組成物を塗布対象に塗布又は噴霧した後、オゾン水を塗布又は噴霧する、オゾン水製造用組成物の使用方法であってもよい。或いは、オゾン水を塗布対象に塗布又は噴霧した後、上記オゾン水製造用組成物を塗布又は噴霧する、使用方法であってもよい。 Yet another embodiment of the present invention may be a method of using the composition for producing ozone water, in which the composition for producing ozone water is applied or sprayed to a target, and then ozone water is applied or sprayed. Alternatively, the method may be a method of using the composition for producing ozone water, in which ozone water is applied or sprayed to a target, and then the composition for producing ozone water is applied or sprayed.
オゾン水生成器（アースウォーカートレーディング株式会社製「オゾンバスター」）を用いてイオン交換水中でオゾンを発生させることによって、オゾン濃度５ｍｇ／Ｌのオゾン水を生成した。このオゾン水に、表１に示す外用成分を、組成物中の濃度が同表に示す値（質量％）になるよう添加して、組成物を調製した。調製後直ちに、荏原実業株式会社製「溶存オゾンチェッカーＤＯＣ－０５Ａ」を用いて、組成物中のオゾン濃度（ｍｇ／Ｌ）を測定した。 Ozone water with an ozone concentration of 5 mg/L was generated by generating ozone in ion-exchanged water using an ozone water generator ("Ozone Buster" manufactured by Earthwalker Trading Co., Ltd.). The topical ingredients shown in Table 1 were added to this ozone water so that the concentrations in the composition were the values (mass%) shown in the same table, to prepare the composition. Immediately after preparation, the ozone concentration (mg/L) in the composition was measured using a "Dissolved Ozone Checker DOC-05A" manufactured by Ebara Jitsugyo Co., Ltd.
表中の％は、質量基準である。 The percentages in the table are by weight.
表１に示すように、トリメチルグリシンを外用成分として使用した組成物（例１及び例２）では、オゾン濃度の低下が抑えられており、組成物調製時の状態が実質的に維持されていると考えられる。一方、トリメチルグリシン以外の外用成分を添加した組成物（例３～例１６）では、オゾン濃度が低下しており、外用成分とオゾンとが反応し、両成分の機能が低下又は消失していると考えられる。 As shown in Table 1, in the compositions using trimethylglycine as the topical ingredient (Examples 1 and 2), the decrease in ozone concentration was suppressed, and it is believed that the state at the time of preparation of the composition was substantially maintained. On the other hand, in the compositions to which topical ingredients other than trimethylglycine were added (Examples 3 to 16), the ozone concentration decreased, and it is believed that the topical ingredient and ozone reacted, causing the functions of both ingredients to decrease or disappear.
Claims (6)
オゾンと、
トリメチルグリシンとを含む、外用水系組成物。 water and,
Ozone and
and trimethylglycine.
トリメチルグリシンとを含む、オゾン水製造用組成物。 water and,
A composition for producing ozone water, comprising:
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| JP2021043649A JP2024060626A (en) | 2021-03-17 | 2021-03-17 | Aqueous composition for external use and composition for producing ozone water |
| PCT/JP2022/010361 WO2022196500A1 (en) | 2021-03-17 | 2022-03-09 | Water-based composition for external use, and composition for producing ozone water |
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| JP2021043649A JP2024060626A (en) | 2021-03-17 | 2021-03-17 | Aqueous composition for external use and composition for producing ozone water |
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| AU2003248582A1 (en) * | 2003-08-01 | 2005-02-15 | Otre Ab | A stabilised ozone solution for use in cleaning systems |
| JP2007332078A (en) * | 2006-06-15 | 2007-12-27 | Ozotech:Kk | Agent for external use containing ozone-dissolved glycerol solution such as cosmetic, quasi-drug or medicament (pharmaceutical) |
| JP5340550B2 (en) * | 2007-02-19 | 2013-11-13 | ライオン株式会社 | Ozone stabilized aqueous solution and production method thereof |
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