JP2023554171A - 個別化がん療法用の高精度薬物スクリーニング - Google Patents
個別化がん療法用の高精度薬物スクリーニング Download PDFInfo
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- JP2023554171A JP2023554171A JP2023558298A JP2023558298A JP2023554171A JP 2023554171 A JP2023554171 A JP 2023554171A JP 2023558298 A JP2023558298 A JP 2023558298A JP 2023558298 A JP2023558298 A JP 2023558298A JP 2023554171 A JP2023554171 A JP 2023554171A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
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- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
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- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
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- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Clinical Laboratory Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Thermal Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063120719P | 2020-12-02 | 2020-12-02 | |
| US63/120,719 | 2020-12-02 | ||
| US202017118586A | 2020-12-10 | 2020-12-10 | |
| US17/118,586 | 2020-12-10 | ||
| PCT/US2021/061471 WO2022119966A1 (en) | 2020-12-02 | 2021-12-01 | Precision drug screening for personalized cancer therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023554171A true JP2023554171A (ja) | 2023-12-26 |
| JP2023554171A5 JP2023554171A5 (https=) | 2024-12-10 |
Family
ID=81260464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023558298A Pending JP2023554171A (ja) | 2020-12-02 | 2021-12-01 | 個別化がん療法用の高精度薬物スクリーニング |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP2023554171A (https=) |
| KR (1) | KR20230143134A (https=) |
| CN (2) | CN114410466A (https=) |
| TW (1) | TW202237858A (https=) |
| WO (1) | WO2022119966A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114410466A (zh) * | 2020-04-01 | 2022-04-29 | 沈西凌 | 用于个性化癌症治疗的精确药物筛选 |
| US20260108889A1 (en) * | 2022-10-12 | 2026-04-23 | University Of Florida Research Foundation, Incorporated | Collagen droplet-based 3d cell spheroids as 3d printable bio-ink |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051329A1 (en) * | 2004-08-27 | 2006-03-09 | The Regents Of The University Of California | Microfluidic device for the encapsulation of cells with low and high cell densities |
| US20170199173A1 (en) * | 2014-06-26 | 2017-07-13 | Northeastern University | Microfluidic Device and Method for Analysis of Tumor Cell Microenvironments |
| US20170369829A1 (en) * | 2015-01-07 | 2017-12-28 | Dana-Farber Cancer Institute, Inc. | Microfluidic cell culture of patient-derived tumor cell spheroids |
| US20200224137A1 (en) * | 2017-07-14 | 2020-07-16 | The Governing Council Of The University Of Toronto | Microfluidic platform for the rapid production of organoids/spheroids for compound screening |
| WO2020215487A1 (zh) * | 2019-04-22 | 2020-10-29 | 清华-伯克利深圳学院筹备办公室 | 一种类器官球体的制备方法 |
| JP2022534778A (ja) * | 2019-05-28 | 2022-08-03 | シリン・シェン | 患者由来ミクロオルガノスフェアのための方法及び装置 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807765B1 (fr) * | 2000-04-18 | 2004-12-31 | Cell Culture Ct Comp | Procede de culture de cellules, amas cellulaires obtenus par ces procedes et utilisation de ceux-ci |
| CA2545482A1 (en) * | 2003-11-10 | 2005-05-26 | Platypus Technologies, Llc | Substrates, devices, and methods for cellular assays |
| AU2006206426B2 (en) * | 2005-01-20 | 2012-03-15 | The Regents Of The University Of California | Cellular microarrays for screening differentiation factors |
| CA2615208A1 (en) * | 2005-07-12 | 2007-01-18 | Tissue Genesis, Inc. | Apparatus and methods for preparing tissue grafts |
| WO2014052835A1 (en) * | 2012-09-29 | 2014-04-03 | Nortis, Inc. | Microfluidic system for reproducing functional units of tissues and organs in vitro |
| KR102257305B1 (ko) * | 2013-03-28 | 2021-05-28 | 더 유니버시티 오브 브리티쉬 콜롬비아 | 미세유동 장치 및 분비물의 다세포 검정법에서의 그의 사용 방법 |
| US20170355950A1 (en) * | 2014-12-04 | 2017-12-14 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Systems for dissociation of biological tissues |
| WO2016145242A1 (en) * | 2015-03-11 | 2016-09-15 | Agenus Inc. | Methods and compositions for high throughput screening of biomolecules using gel microdrops |
| KR20190118702A (ko) * | 2018-04-11 | 2019-10-21 | 연세대학교 산학협력단 | 환자 유래 종양세포를 이용한 생체외 조직체 구조물 및 이의 제조방법 |
| CN114410466A (zh) * | 2020-04-01 | 2022-04-29 | 沈西凌 | 用于个性化癌症治疗的精确药物筛选 |
-
2021
- 2021-04-01 CN CN202110357675.1A patent/CN114410466A/zh active Pending
- 2021-04-01 CN CN202120671205.8U patent/CN218755788U/zh active Active
- 2021-12-01 KR KR1020237022216A patent/KR20230143134A/ko active Pending
- 2021-12-01 JP JP2023558298A patent/JP2023554171A/ja active Pending
- 2021-12-01 WO PCT/US2021/061471 patent/WO2022119966A1/en not_active Ceased
- 2021-12-02 TW TW110144981A patent/TW202237858A/zh unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060051329A1 (en) * | 2004-08-27 | 2006-03-09 | The Regents Of The University Of California | Microfluidic device for the encapsulation of cells with low and high cell densities |
| US20170199173A1 (en) * | 2014-06-26 | 2017-07-13 | Northeastern University | Microfluidic Device and Method for Analysis of Tumor Cell Microenvironments |
| US20170369829A1 (en) * | 2015-01-07 | 2017-12-28 | Dana-Farber Cancer Institute, Inc. | Microfluidic cell culture of patient-derived tumor cell spheroids |
| US20200224137A1 (en) * | 2017-07-14 | 2020-07-16 | The Governing Council Of The University Of Toronto | Microfluidic platform for the rapid production of organoids/spheroids for compound screening |
| WO2020215487A1 (zh) * | 2019-04-22 | 2020-10-29 | 清华-伯克利深圳学院筹备办公室 | 一种类器官球体的制备方法 |
| JP2022534778A (ja) * | 2019-05-28 | 2022-08-03 | シリン・シェン | 患者由来ミクロオルガノスフェアのための方法及び装置 |
Non-Patent Citations (3)
| Title |
|---|
| ACS APPLIED BIO MATERIALS, vol. 3, no. 9, JPN6025046324, 2 August 2020 (2020-08-02), pages 6273 - 6283, ISSN: 0005733254 * |
| PHARMACEUTICS, vol. 10, no. 4, JPN6025046325, 2018, pages 229, ISSN: 0005733256 * |
| SCI. ADV., vol. 4, no. 4, JPN6025046326, 2018, pages 8998, ISSN: 0005733255 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN218755788U (zh) | 2023-03-28 |
| KR20230143134A (ko) | 2023-10-11 |
| TW202237858A (zh) | 2022-10-01 |
| CN114410466A (zh) | 2022-04-29 |
| WO2022119966A1 (en) | 2022-06-09 |
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