JP2023554171A - 個別化がん療法用の高精度薬物スクリーニング - Google Patents

個別化がん療法用の高精度薬物スクリーニング Download PDF

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JP2023554171A
JP2023554171A JP2023558298A JP2023558298A JP2023554171A JP 2023554171 A JP2023554171 A JP 2023554171A JP 2023558298 A JP2023558298 A JP 2023558298A JP 2023558298 A JP2023558298 A JP 2023558298A JP 2023554171 A JP2023554171 A JP 2023554171A
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microorganospheres
patient
derived
cells
dissociated
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シリン・シェン
デイヴィッド・スー
ジェフリー・モッチマン
ダニエル・デルバック
ジャオフイ・ワン
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Duke University
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • C40COMBINATORIAL TECHNOLOGY
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    • C40B30/06Methods of screening libraries by measuring effects on living organisms, tissues or cells
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    • C40COMBINATORIAL TECHNOLOGY
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    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2200/10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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JP2023558298A 2020-12-02 2021-12-01 個別化がん療法用の高精度薬物スクリーニング Pending JP2023554171A (ja)

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Application Number Priority Date Filing Date Title
US202063120719P 2020-12-02 2020-12-02
US63/120,719 2020-12-02
US202017118586A 2020-12-10 2020-12-10
US17/118,586 2020-12-10
PCT/US2021/061471 WO2022119966A1 (en) 2020-12-02 2021-12-01 Precision drug screening for personalized cancer therapy

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JP2023554171A true JP2023554171A (ja) 2023-12-26
JP2023554171A5 JP2023554171A5 (https=) 2024-12-10

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JP (1) JP2023554171A (https=)
KR (1) KR20230143134A (https=)
CN (2) CN114410466A (https=)
TW (1) TW202237858A (https=)
WO (1) WO2022119966A1 (https=)

Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
CN114410466A (zh) * 2020-04-01 2022-04-29 沈西凌 用于个性化癌症治疗的精确药物筛选
US20260108889A1 (en) * 2022-10-12 2026-04-23 University Of Florida Research Foundation, Incorporated Collagen droplet-based 3d cell spheroids as 3d printable bio-ink

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US20060051329A1 (en) * 2004-08-27 2006-03-09 The Regents Of The University Of California Microfluidic device for the encapsulation of cells with low and high cell densities
US20170199173A1 (en) * 2014-06-26 2017-07-13 Northeastern University Microfluidic Device and Method for Analysis of Tumor Cell Microenvironments
US20170369829A1 (en) * 2015-01-07 2017-12-28 Dana-Farber Cancer Institute, Inc. Microfluidic cell culture of patient-derived tumor cell spheroids
US20200224137A1 (en) * 2017-07-14 2020-07-16 The Governing Council Of The University Of Toronto Microfluidic platform for the rapid production of organoids/spheroids for compound screening
WO2020215487A1 (zh) * 2019-04-22 2020-10-29 清华-伯克利深圳学院筹备办公室 一种类器官球体的制备方法
JP2022534778A (ja) * 2019-05-28 2022-08-03 シリン・シェン 患者由来ミクロオルガノスフェアのための方法及び装置

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CN114410466A (zh) * 2020-04-01 2022-04-29 沈西凌 用于个性化癌症治疗的精确药物筛选

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* Cited by examiner, † Cited by third party
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US20060051329A1 (en) * 2004-08-27 2006-03-09 The Regents Of The University Of California Microfluidic device for the encapsulation of cells with low and high cell densities
US20170199173A1 (en) * 2014-06-26 2017-07-13 Northeastern University Microfluidic Device and Method for Analysis of Tumor Cell Microenvironments
US20170369829A1 (en) * 2015-01-07 2017-12-28 Dana-Farber Cancer Institute, Inc. Microfluidic cell culture of patient-derived tumor cell spheroids
US20200224137A1 (en) * 2017-07-14 2020-07-16 The Governing Council Of The University Of Toronto Microfluidic platform for the rapid production of organoids/spheroids for compound screening
WO2020215487A1 (zh) * 2019-04-22 2020-10-29 清华-伯克利深圳学院筹备办公室 一种类器官球体的制备方法
JP2022534778A (ja) * 2019-05-28 2022-08-03 シリン・シェン 患者由来ミクロオルガノスフェアのための方法及び装置

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CN218755788U (zh) 2023-03-28
KR20230143134A (ko) 2023-10-11
TW202237858A (zh) 2022-10-01
CN114410466A (zh) 2022-04-29
WO2022119966A1 (en) 2022-06-09

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