JP2023549850A - マルチパラメトリックな発見および最適化プラットフォーム - Google Patents

マルチパラメトリックな発見および最適化プラットフォーム Download PDF

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JP2023549850A
JP2023549850A JP2023528634A JP2023528634A JP2023549850A JP 2023549850 A JP2023549850 A JP 2023549850A JP 2023528634 A JP2023528634 A JP 2023528634A JP 2023528634 A JP2023528634 A JP 2023528634A JP 2023549850 A JP2023549850 A JP 2023549850A
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cells
library
variants
polymer
variant
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JP2023549850A5 (enExample
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ジェレミー アグレスティ，
バルガス， アンドレス オルネラス
ケビン グレゴリー ホフ，
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トリプルバー バイオ， インコーポレイテッド
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/50—Mutagenesis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B35/00—ICT specially adapted for in silico combinatorial libraries of nucleic acids, proteins or peptides
    • G16B35/10—Design of libraries
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00—Subject matter not provided for in other groups of this subclass

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  • Proteomics, Peptides & Aminoacids (AREA)
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JP2023528634A 2020-11-13 2021-11-13 マルチパラメトリックな発見および最適化プラットフォーム Pending JP2023549850A (ja)

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US202063113571P 2020-11-13 2020-11-13
US63/113,571 2020-11-13
PCT/US2021/059275 WO2022104164A1 (en) 2020-11-13 2021-11-13 Multiparametric discovery and optimization platform

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JP2023549850A true JP2023549850A (ja) 2023-11-29
JP2023549850A5 JP2023549850A5 (enExample) 2024-11-11

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US (3) US11923045B2 (enExample)
EP (1) EP4244353A4 (enExample)
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CN (1) CN116917474A (enExample)
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WO2022104164A1 (en) 2020-11-13 2022-05-19 Triplebar Bio, Inc. Multiparametric discovery and optimization platform
CN116047038B (zh) * 2022-12-21 2025-04-25 南雄市沃太化工有限公司 一种树脂固化条件的实验方法、装置、存储介质及设备
WO2025184561A1 (en) * 2024-03-01 2025-09-04 Deepmind Technologies Limited Optimizing molecule fitness using multiple diverse molecule design techniques
CN119580852B (zh) * 2024-11-19 2025-09-26 中国热带农业科学院环境与植物保护研究所 一种宏基因组数据集的生物地球化学元素循环分析方法及系统

Citations (2)

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US20100100331A1 (en) * 2003-08-01 2010-04-22 Dna Twopointo Inc. Systems and methods for biopolymer engineering
WO2020148956A1 (ja) * 2019-01-18 2020-07-23 富士フイルム株式会社 細胞生成支援装置、方法、及びプログラム

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EP2250594B1 (en) * 2008-02-12 2017-04-19 Codexis, Inc. Method of generating an optimized, diverse population of variants
WO2010111231A1 (en) * 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
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WO2022104164A1 (en) 2020-11-13 2022-05-19 Triplebar Bio, Inc. Multiparametric discovery and optimization platform

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WO2020148956A1 (ja) * 2019-01-18 2020-07-23 富士フイルム株式会社 細胞生成支援装置、方法、及びプログラム

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JSBI BIOINFORMATICS REVIEW, vol. 1, no. 1, JPN6025042706, 30 September 2020 (2020-09-30), pages 12 - 17, ISSN: 0005710256 *
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CN116917474A (zh) 2023-10-20
EP4244353A4 (en) 2024-10-30
US20230174968A1 (en) 2023-06-08
GB2617285A (en) 2023-10-04
WO2022104164A1 (en) 2022-05-19
US20230154562A1 (en) 2023-05-18
US20250061962A1 (en) 2025-02-20
US11972840B2 (en) 2024-04-30
GB202308819D0 (en) 2023-07-26
EP4244353A1 (en) 2023-09-20
US11923045B2 (en) 2024-03-05

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