JP2023546022A - 腸内での繊維合成酵素の発現のための操作されたプロバイオティクス - Google Patents

腸内での繊維合成酵素の発現のための操作されたプロバイオティクス Download PDF

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JP2023546022A
JP2023546022A JP2023521480A JP2023521480A JP2023546022A JP 2023546022 A JP2023546022 A JP 2023546022A JP 2023521480 A JP2023521480 A JP 2023521480A JP 2023521480 A JP2023521480 A JP 2023521480A JP 2023546022 A JP2023546022 A JP 2023546022A
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fiber
synthase
bacillus
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JP2023546022A5 (enExample
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ザッカリー ディー． アボット
ジョン ウィリアム キッダー オリバー
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ジーバイオティクス カンパニー
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
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    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
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    • A61K35/74—Bacteria
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    • A61K35/74—Bacteria
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    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C12N9/1055—Levansucrase (2.4.1.10)
    • C—CHEMISTRY; METALLURGY
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    • C12N9/90—Isomerases (5.)
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/0101—Levansucrase (2.4.1.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99011—Isomaltulose synthase (5.4.99.11)
    • C—CHEMISTRY; METALLURGY
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    • C12N2800/101—Plasmid DNA for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

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  • Health & Medical Sciences (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2023521480A 2020-10-08 2021-10-07 腸内での繊維合成酵素の発現のための操作されたプロバイオティクス Pending JP2023546022A (ja)

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US202063089334P 2020-10-08 2020-10-08
US63/089,334 2020-10-08
PCT/US2021/053983 WO2022076693A1 (en) 2020-10-08 2021-10-07 Engineered probiotics for expression of fiber-synthesizing enzymes in gut

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JP2023546022A true JP2023546022A (ja) 2023-11-01
JP2023546022A5 JP2023546022A5 (enExample) 2024-10-10

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US (1) US20230372453A1 (enExample)
EP (1) EP4225338A4 (enExample)
JP (1) JP2023546022A (enExample)
KR (1) KR20230088715A (enExample)
CN (1) CN116528880A (enExample)
AU (1) AU2021358080A1 (enExample)
CA (1) CA3194677A1 (enExample)
GB (1) GB2616358A (enExample)
MX (1) MX2023003972A (enExample)
WO (1) WO2022076693A1 (enExample)

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US10849938B2 (en) 2017-09-13 2020-12-01 ZBiotics Company Gene expression system for probiotic microorganisms

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018631A1 (en) * 1991-04-22 1992-10-29 Cetus Oncology Corporation Methods and nucleic acid sequences for the expression of the cellulose synthase operon
JP2017536131A (ja) * 2014-12-05 2017-12-07 ダニスコ・ユーエス・インク バチルス・アガラドヘレンス（ｂａｃｉｌｌｕｓ ａｇａｒａｄｈａｅｒｅｎｓ）イヌロスクラーゼ（ｉｎｕｏ）の使用を含む組成物および方法
WO2019055707A1 (en) * 2017-09-13 2019-03-21 ZBiotics Company GENE EXPRESSION SYSTEM FOR PROBIOTIC MICROORGANISMS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10106163B4 (de) * 2000-12-21 2007-03-29 Südzucker AG Mannheim/Ochsenfurt Verfahren zur Herstellung von Kohlenhydraten
US8734814B2 (en) * 2012-03-02 2014-05-27 Asis Datta Recombinant microorganisms and uses thereof
JP2022512639A (ja) * 2018-10-09 2022-02-07 セカンド ゲノム インコーポレイテッド 上皮バリア機能障害の治療に有効なタンパク質を送達するためのラクトコッカス・ラクティス発現系
ES2966260T3 (es) * 2020-08-10 2024-04-19 Inbiose Nv Producción de una mezcla de oligosacáridos neutros no fucosilados por una célula

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992018631A1 (en) * 1991-04-22 1992-10-29 Cetus Oncology Corporation Methods and nucleic acid sequences for the expression of the cellulose synthase operon
JP2017536131A (ja) * 2014-12-05 2017-12-07 ダニスコ・ユーエス・インク バチルス・アガラドヘレンス（ｂａｃｉｌｌｕｓ ａｇａｒａｄｈａｅｒｅｎｓ）イヌロスクラーゼ（ｉｎｕｏ）の使用を含む組成物および方法
WO2019055707A1 (en) * 2017-09-13 2019-03-21 ZBiotics Company GENE EXPRESSION SYSTEM FOR PROBIOTIC MICROORGANISMS

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AU2021358080A9 (en) 2024-08-01
EP4225338A4 (en) 2024-11-06
GB2616358A (en) 2023-09-06
US20230372453A1 (en) 2023-11-23
WO2022076693A1 (en) 2022-04-14
AU2021358080A1 (en) 2023-05-04
CA3194677A1 (en) 2022-04-14
GB202306208D0 (en) 2023-06-14
KR20230088715A (ko) 2023-06-20
EP4225338A1 (en) 2023-08-16
MX2023003972A (es) 2023-06-19
CN116528880A (zh) 2023-08-01

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