JP2023544720A - Dnaメチル化分配アッセイのシグナル対ノイズ比を改善するための方法およびシステム - Google Patents
Dnaメチル化分配アッセイのシグナル対ノイズ比を改善するための方法およびシステム Download PDFInfo
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- JP2023544720A JP2023544720A JP2023519657A JP2023519657A JP2023544720A JP 2023544720 A JP2023544720 A JP 2023544720A JP 2023519657 A JP2023519657 A JP 2023519657A JP 2023519657 A JP2023519657 A JP 2023519657A JP 2023544720 A JP2023544720 A JP 2023544720A
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- C12Q2600/112—Disease subtyping, staging or classification
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- C12Q2600/154—Methylation markers
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- C12Q2600/156—Polymorphic or mutational markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063086000P | 2020-09-30 | 2020-09-30 | |
| US63/086,000 | 2020-09-30 | ||
| US202063105183P | 2020-10-23 | 2020-10-23 | |
| US63/105,183 | 2020-10-23 | ||
| PCT/US2021/071648 WO2022073011A1 (en) | 2020-09-30 | 2021-09-29 | Methods and systems to improve the signal to noise ratio of dna methylation partitioning assays |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023544720A true JP2023544720A (ja) | 2023-10-25 |
| JPWO2022073011A5 JPWO2022073011A5 (https=) | 2024-09-30 |
| JP2023544720A5 JP2023544720A5 (https=) | 2024-09-30 |
Family
ID=78333328
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023519657A Pending JP2023544720A (ja) | 2020-09-30 | 2021-09-29 | Dnaメチル化分配アッセイのシグナル対ノイズ比を改善するための方法およびシステム |
| JP2023519658A Pending JP2023544721A (ja) | 2020-09-30 | 2021-09-29 | 分配およびメチル化依存性ヌクレアーゼを使用してdnaを解析するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023519658A Pending JP2023544721A (ja) | 2020-09-30 | 2021-09-29 | 分配およびメチル化依存性ヌクレアーゼを使用してdnaを解析するための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20220154285A1 (https=) |
| EP (2) | EP4222279A1 (https=) |
| JP (2) | JP2023544720A (https=) |
| CA (2) | CA3193183A1 (https=) |
| WO (2) | WO2022073011A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12234518B2 (en) | 2020-10-23 | 2025-02-25 | Guardant Health, Inc. | Compositions and methods for analyzing DNA using partitioning and base conversion |
| EP4314329A1 (en) * | 2021-03-25 | 2024-02-07 | Guardant Health, Inc. | Methods and compositions for quantifying immune cell dna |
| IL293202A (en) * | 2022-05-22 | 2023-12-01 | Nucleix Ltd | Useful combinations of restriction enzymes |
| WO2023244983A1 (en) * | 2022-06-13 | 2023-12-21 | Freenome Holdings, Inc. | Sequence process validation methods and compositions |
| JP2025522763A (ja) * | 2022-06-30 | 2025-07-17 | ガーダント ヘルス, インコーポレイテッド | 異常にメチル化されたdnaの富化 |
| NL2033070B1 (en) * | 2022-09-19 | 2024-03-25 | Univ Twente | Method for detecting CpG methylation in a DNA target sequence |
| JP2026501670A (ja) * | 2023-01-04 | 2026-01-16 | ナテラ, インコーポレイテッド | メチル化標的dna分子を増幅するための方法および組成物 |
| WO2024159118A1 (en) * | 2023-01-27 | 2024-08-02 | The Regents Of The University Of California | Methods of hyper- and hypo-methylation analysis for disease detection |
| WO2024211551A1 (en) | 2023-04-06 | 2024-10-10 | Glaxosmithkline Intellectual Property (No.4) Limited | Methods for treating and monitoring cancer |
| EP4713480A1 (en) * | 2023-05-19 | 2026-03-25 | Nucleix Ltd. | Detecting methylation changes in dna samples using restriction enzymes and high throughput sequencing |
| CN116926194A (zh) * | 2023-06-29 | 2023-10-24 | 纳昂达(南京)生物科技有限公司 | 一种检测dna样本甲基化状态的方法 |
| WO2025106807A1 (en) * | 2023-11-16 | 2025-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Classification of samples using methylation enrichment |
| WO2025165106A1 (ko) * | 2024-01-29 | 2025-08-07 | 주식회사 지씨지놈 | 핵산의 메틸화 마커 검출 방법 |
Citations (3)
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| JP2007512806A (ja) * | 2003-10-21 | 2007-05-24 | オリオン ゲノミクス エルエルシー | 差次的酵素的断片化の方法 |
| JP2020504606A (ja) * | 2016-12-22 | 2020-02-13 | ガーダント ヘルス, インコーポレイテッド | 核酸分子を解析するための方法およびシステム |
| WO2020160414A1 (en) * | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
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| JP3102800B2 (ja) | 1994-08-19 | 2000-10-23 | パーキン−エルマー コーポレイション | 増幅及び連結反応の共役法 |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
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| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
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| US8394584B2 (en) * | 2008-12-19 | 2013-03-12 | The Board Of Trustees Of The University Of Illinois | Detecting and sorting methylated DNA using a synthetic nanopore |
| US20130157266A1 (en) | 2009-03-15 | 2013-06-20 | Ribomed Biotechnologies, Inc. | Abscription based molecular detection of dna methylation |
| US20110237444A1 (en) * | 2009-11-20 | 2011-09-29 | Life Technologies Corporation | Methods of mapping genomic methylation patterns |
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2021
- 2021-09-29 US US17/489,687 patent/US20220154285A1/en active Pending
- 2021-09-29 JP JP2023519657A patent/JP2023544720A/ja active Pending
- 2021-09-29 EP EP21806592.8A patent/EP4222279A1/en active Pending
- 2021-09-29 US US17/489,677 patent/US20220162670A1/en active Pending
- 2021-09-29 WO PCT/US2021/071648 patent/WO2022073011A1/en not_active Ceased
- 2021-09-29 CA CA3193183A patent/CA3193183A1/en active Pending
- 2021-09-29 EP EP21798252.9A patent/EP4222278A1/en active Pending
- 2021-09-29 JP JP2023519658A patent/JP2023544721A/ja active Pending
- 2021-09-29 CA CA3193090A patent/CA3193090A1/en active Pending
- 2021-09-29 WO PCT/US2021/071649 patent/WO2022073012A1/en not_active Ceased
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2022
- 2022-12-22 US US18/087,724 patent/US11946106B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007512806A (ja) * | 2003-10-21 | 2007-05-24 | オリオン ゲノミクス エルエルシー | 差次的酵素的断片化の方法 |
| JP2020504606A (ja) * | 2016-12-22 | 2020-02-13 | ガーダント ヘルス, インコーポレイテッド | 核酸分子を解析するための方法およびシステム |
| WO2020160414A1 (en) * | 2019-01-31 | 2020-08-06 | Guardant Health, Inc. | Compositions and methods for isolating cell-free dna |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023544721A (ja) | 2023-10-25 |
| US20220154285A1 (en) | 2022-05-19 |
| WO2022073012A1 (en) | 2022-04-07 |
| CA3193183A1 (en) | 2022-04-07 |
| US20220162670A1 (en) | 2022-05-26 |
| US11946106B2 (en) | 2024-04-02 |
| EP4222278A1 (en) | 2023-08-09 |
| WO2022073011A1 (en) | 2022-04-07 |
| EP4222279A1 (en) | 2023-08-09 |
| US20230130140A1 (en) | 2023-04-27 |
| CA3193090A1 (en) | 2022-04-07 |
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