JP2023539589A - Ｅｇｆｒ変異を有する非小細胞肺がんの治療 - Google Patents

Ｅｇｆｒ変異を有する非小細胞肺がんの治療 Download PDF

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Publication number
JP2023539589A
JP2023539589A JP2023513309A JP2023513309A JP2023539589A JP 2023539589 A JP2023539589 A JP 2023539589A JP 2023513309 A JP2023513309 A JP 2023513309A JP 2023513309 A JP2023513309 A JP 2023513309A JP 2023539589 A JP2023539589 A JP 2023539589A
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egfr
cancer
seq
amivantamab
shows
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Japanese (ja)
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JP2023539589A5 (https=
JPWO2022043895A5 (https=
Inventor
ノブロック，ローランド
ムーアズ，シェリ
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ヤンセン バイオテツク，インコーポレーテツド
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Publication of JP2023539589A publication Critical patent/JP2023539589A/ja
Publication of JP2023539589A5 publication Critical patent/JP2023539589A5/ja
Publication of JPWO2022043895A5 publication Critical patent/JPWO2022043895A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2023513309A 2020-08-25 2021-08-25 Ｅｇｆｒ変異を有する非小細胞肺がんの治療 Pending JP2023539589A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063069748P 2020-08-25 2020-08-25
US63/069,748 2020-08-25
PCT/IB2021/057794 WO2022043895A2 (en) 2020-08-25 2021-08-25 Treatment of non-small lung cancer with egfr mutations

Publications (3)

Publication Number Publication Date
JP2023539589A true JP2023539589A (ja) 2023-09-15
JP2023539589A5 JP2023539589A5 (https=) 2024-09-02
JPWO2022043895A5 JPWO2022043895A5 (https=) 2024-09-02

Family

ID=80352814

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023513309A Pending JP2023539589A (ja) 2020-08-25 2021-08-25 Ｅｇｆｒ変異を有する非小細胞肺がんの治療

Country Status (11)

Country Link
US (2) US12528869B2 (https=)
EP (1) EP4204455A4 (https=)
JP (1) JP2023539589A (https=)
KR (1) KR20230053686A (https=)
CN (1) CN116194141A (https=)
AU (1) AU2021330539A1 (https=)
CA (1) CA3192922A1 (https=)
IL (1) IL300854A (https=)
JO (1) JOP20230039A1 (https=)
MX (1) MX2023002362A (https=)
WO (1) WO2022043895A2 (https=)

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Publication number Priority date Publication date Assignee Title
US20230174677A1 (en) * 2021-11-16 2023-06-08 Janssen Biotech, Inc. Use of Approved Bispecific EGFR and Met Specific Antibody Drug Product to Treat Non-Small Cell Lung Cancer (NSCLCL)
US20240317866A1 (en) * 2022-06-30 2024-09-26 Janssen Biotech, Inc. Use of Anti-EGFR/Anti-Met Antibody to Treat Gastric or Esophageal Cancer
WO2024108193A2 (en) * 2022-11-18 2024-05-23 Epibiologics, Inc. Degradation of cmet using a bispecific binding agent
CN116284335A (zh) * 2023-03-17 2023-06-23 云南中医药大学 Egfr基因突变体的检测方法及应用
WO2025158277A1 (en) * 2024-01-22 2025-07-31 Janssen Biotech, Inc. Use of amivantamab to treat head and neck cancer

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GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
EP1766068A4 (en) 2004-06-04 2010-03-03 Genentech Inc EGFR Mutations
EP1789446A2 (en) 2004-09-02 2007-05-30 Genentech, Inc. Heteromultimeric molecules
EP3050963B1 (en) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
US8871912B2 (en) 2006-03-24 2014-10-28 Merck Patent Gmbh Engineered heterodimeric protein domains
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
KR20100058509A (ko) 2007-07-31 2010-06-03 메디뮨 엘엘씨 다중특이적 에피토프 결합 단백질 및 이의 용도
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
JP2012525149A (ja) 2009-04-27 2012-10-22 オンコメッド ファーマシューティカルズ インコーポレイテッド ヘテロ多量体分子を作製するための方法
EP3511342B1 (en) 2010-03-10 2024-01-17 Genmab A/S Monoclonal antibodies against c-met
DK2560993T3 (da) 2010-04-20 2024-10-14 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
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EP3029067A1 (en) 2014-12-01 2016-06-08 Deutsches Krebsforschungszentrum Use of blocking-reagents for reducing unspecific T cell-activation
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
MA46852A (fr) 2016-11-17 2019-09-25 Univ Texas Composés à activité antitumorale contre des cellules cancéreuses porteuses de mutations egfr ou her2 exon 20
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CRITICAL REVIEWS IN ONCOLOGY/HEMATOLOGY, vol. Volume 148, 102906, JPN6025036570, April 2020 (2020-04-01), pages 1 - 13, ISSN: 0005683349 *

Also Published As

Publication number Publication date
CA3192922A1 (en) 2022-03-03
MX2023002362A (es) 2023-05-19
US20260070993A1 (en) 2026-03-12
EP4204455A2 (en) 2023-07-05
WO2022043895A3 (en) 2022-06-09
KR20230053686A (ko) 2023-04-21
WO2022043895A2 (en) 2022-03-03
WO2022043895A8 (en) 2023-03-09
CN116194141A (zh) 2023-05-30
AU2021330539A1 (en) 2023-05-04
IL300854A (en) 2023-04-01
US12528869B2 (en) 2026-01-20
JOP20230039A1 (ar) 2023-02-23
AU2021330539A9 (en) 2023-07-13
EP4204455A4 (en) 2024-10-16
US20220064306A1 (en) 2022-03-03

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