JP2023537271A - チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 - Google Patents
チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 Download PDFInfo
- Publication number
- JP2023537271A JP2023537271A JP2023504724A JP2023504724A JP2023537271A JP 2023537271 A JP2023537271 A JP 2023537271A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023504724 A JP2023504724 A JP 2023504724A JP 2023537271 A JP2023537271 A JP 2023537271A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heterocycloalkyl
- aryl
- cycloalkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063056165P | 2020-07-24 | 2020-07-24 | |
| US63/056,165 | 2020-07-24 | ||
| US202063113555P | 2020-11-13 | 2020-11-13 | |
| US63/113,555 | 2020-11-13 | ||
| PCT/US2021/042960 WO2022020714A1 (en) | 2020-07-24 | 2021-07-23 | Thiophene hsd17b13 inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023537271A true JP2023537271A (ja) | 2023-08-31 |
| JPWO2022020714A5 JPWO2022020714A5 (https=) | 2024-07-18 |
| JP2023537271A5 JP2023537271A5 (https=) | 2024-07-18 |
Family
ID=79729016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023504724A Pending JP2023537271A (ja) | 2020-07-24 | 2021-07-23 | チオフェンｈｓｄ１７ｂ１３阻害剤とその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230278978A1 (https=) |
| EP (1) | EP4185381A4 (https=) |
| JP (1) | JP2023537271A (https=) |
| CN (1) | CN116323578A (https=) |
| TW (1) | TW202220967A (https=) |
| WO (1) | WO2022020714A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116670118B (zh) | 2020-11-13 | 2026-02-06 | 伊尼制药公司 | 二氯苯酚hsd17b13抑制剂及其用途 |
| EP4320111A4 (en) * | 2021-04-05 | 2025-03-12 | Inipharm, Inc. | HYDROXYPYRIDINE-TYPE HSD17B13 INHIBITORS AND USES THEREOF |
| CN118103038A (zh) | 2021-08-20 | 2024-05-28 | 英安塔制药有限公司 | 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法 |
| JP2024546946A (ja) * | 2021-12-15 | 2024-12-26 | ブリストル－マイヤーズ スクイブ カンパニー | ベンゾチオフェンｒｘｆｐ１アゴニスト |
| JP2025503953A (ja) * | 2022-01-26 | 2025-02-06 | イニファーム，インク． | ２－置換チアゾールｈｓｄ１７ｂ１３阻害剤およびその使用 |
| DK4514782T3 (da) | 2022-05-19 | 2025-12-15 | Astrazeneca Ab | Heteroaromatiske amidoforbindelser, der er nyttige ved behandling af leversygdomme |
| JP2025523357A (ja) | 2022-06-09 | 2025-07-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｈｓｄ１７ｂ１３阻害剤 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006040966A1 (ja) * | 2004-10-08 | 2006-04-20 | Astellas Pharma Inc. | 芳香環縮合ピリミジン誘導体 |
| US20090023710A1 (en) * | 2005-07-04 | 2009-01-22 | Nigel Vicker | Compound |
| JP2013530240A (ja) * | 2010-07-02 | 2013-07-25 | ギリアード サイエンシーズ， インコーポレイテッド | アポトーシスシグナル調節キナーゼ阻害剤 |
| JP2014514257A (ja) * | 2011-03-03 | 2014-06-19 | ユニバーシテーテ デス ザールランデス | 選択的１７ベータ−ヒドロキシステロイドデヒドロゲナーゼ２型阻害剤としてのビアリール誘導体 |
| WO2018204775A1 (en) * | 2017-05-05 | 2018-11-08 | Hepanova, Inc. | Amino-aryl-benzamide compounds and methods of use thereof |
| WO2019154956A1 (en) * | 2018-02-08 | 2019-08-15 | Enyo Pharma | Non-fused thiophene derivatives and their uses |
| WO2019183329A1 (en) * | 2018-03-21 | 2019-09-26 | Ionis Pharmaceuticals, Inc. | Modulation of hsd17b13 expression |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| WO2004085382A1 (ja) * | 2003-03-27 | 2004-10-07 | Kirin Beer Kabushiki Kaisha | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
| CN101287728A (zh) * | 2005-08-17 | 2008-10-15 | 先灵公司 | 新的高亲和力噻吩基和呋喃基激酶配体 |
| WO2013165606A1 (en) * | 2012-05-04 | 2013-11-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of the relaxin receptor 1 |
| CN105524053B (zh) * | 2014-10-19 | 2020-06-05 | 广东东阳光药业有限公司 | 四氢苯并噻吩化合物 |
| DK3356345T3 (da) * | 2015-09-30 | 2024-02-12 | Max Planck Gesellschaft | Heteroaryl-derivater som sepiapterin-reduktase-inhibitorer |
| KR101870968B1 (ko) * | 2016-02-02 | 2018-06-25 | 부산대학교 산학협력단 | Ppar, fxr 및 ampk 활성화 효능을 갖는 신규 티오펜 화합물 또는 이의 약제학적으로 허용 가능한 염 및 이의 의학적 용도 |
| SI3497091T1 (sl) * | 2016-08-15 | 2020-11-30 | Eli Lilly And Company | Kondenzirani derivati tiofena uporabni kot inhibitorji NAPI-IIB |
-
2021
- 2021-07-23 WO PCT/US2021/042960 patent/WO2022020714A1/en not_active Ceased
- 2021-07-23 TW TW110127231A patent/TW202220967A/zh unknown
- 2021-07-23 CN CN202180065663.XA patent/CN116323578A/zh active Pending
- 2021-07-23 JP JP2023504724A patent/JP2023537271A/ja active Pending
- 2021-07-23 EP EP21846586.2A patent/EP4185381A4/en active Pending
- 2021-07-23 US US18/006,059 patent/US20230278978A1/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006040966A1 (ja) * | 2004-10-08 | 2006-04-20 | Astellas Pharma Inc. | 芳香環縮合ピリミジン誘導体 |
| US20090023710A1 (en) * | 2005-07-04 | 2009-01-22 | Nigel Vicker | Compound |
| JP2013530240A (ja) * | 2010-07-02 | 2013-07-25 | ギリアード サイエンシーズ， インコーポレイテッド | アポトーシスシグナル調節キナーゼ阻害剤 |
| JP2014514257A (ja) * | 2011-03-03 | 2014-06-19 | ユニバーシテーテ デス ザールランデス | 選択的１７ベータ−ヒドロキシステロイドデヒドロゲナーゼ２型阻害剤としてのビアリール誘導体 |
| WO2018204775A1 (en) * | 2017-05-05 | 2018-11-08 | Hepanova, Inc. | Amino-aryl-benzamide compounds and methods of use thereof |
| WO2019154956A1 (en) * | 2018-02-08 | 2019-08-15 | Enyo Pharma | Non-fused thiophene derivatives and their uses |
| WO2019183329A1 (en) * | 2018-03-21 | 2019-09-26 | Ionis Pharmaceuticals, Inc. | Modulation of hsd17b13 expression |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022020714A1 (en) | 2022-01-27 |
| CN116323578A (zh) | 2023-06-23 |
| US20230278978A1 (en) | 2023-09-07 |
| EP4185381A1 (en) | 2023-05-31 |
| EP4185381A4 (en) | 2024-08-21 |
| TW202220967A (zh) | 2022-06-01 |
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