JP2023536920A5 - - Google Patents
Info
- Publication number
- JP2023536920A5 JP2023536920A5 JP2023507619A JP2023507619A JP2023536920A5 JP 2023536920 A5 JP2023536920 A5 JP 2023536920A5 JP 2023507619 A JP2023507619 A JP 2023507619A JP 2023507619 A JP2023507619 A JP 2023507619A JP 2023536920 A5 JP2023536920 A5 JP 2023536920A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutically acceptable
- acceptable salt
- inventions
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063061515P | 2020-08-05 | 2020-08-05 | |
| US63/061,515 | 2020-08-05 | ||
| PCT/US2021/044673 WO2022031928A1 (en) | 2020-08-05 | 2021-08-05 | Salt inducible kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023536920A JP2023536920A (ja) | 2023-08-30 |
| JP2023536920A5 true JP2023536920A5 (https=) | 2024-08-09 |
Family
ID=80118533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023507619A Pending JP2023536920A (ja) | 2020-08-05 | 2021-08-05 | 塩誘導性キナーゼ阻害剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12600719B2 (https=) |
| EP (2) | EP4660192A1 (https=) |
| JP (1) | JP2023536920A (https=) |
| KR (1) | KR20230049102A (https=) |
| CN (1) | CN116234549B (https=) |
| AU (1) | AU2021320860A1 (https=) |
| BR (1) | BR112023001952A2 (https=) |
| CA (1) | CA3190172A1 (https=) |
| IL (1) | IL300205A (https=) |
| MX (1) | MX2023001236A (https=) |
| WO (1) | WO2022031928A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11241435B2 (en) | 2016-09-16 | 2022-02-08 | The General Hospital Corporation | Uses of salt-inducible kinase (SIK) inhibitors for treating osteoporosis |
| EP3717471B1 (en) | 2017-12-02 | 2022-01-05 | Galapagos NV | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| MA52873A (fr) | 2018-06-15 | 2021-04-21 | Galapagos Nv | Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies |
| CN117843634A (zh) * | 2022-05-24 | 2024-04-09 | 上海美悦生物科技发展有限公司 | Sik抑制剂及其组合物、制备方法和用途 |
| JP2025523524A (ja) * | 2022-07-01 | 2025-07-23 | エフ． ホフマン－ラ ロシュ アーゲー | 関節リウマチの処置のためのＳＩＫモジュレーターとしてのイミダゾ［４，５－ｂ］ピリジンおよびピラゾロ［１，５－ａ］ピリミジン誘導体 |
| US20240124450A1 (en) * | 2022-09-21 | 2024-04-18 | Pfizer Inc. | Novel SIK Inhibitors |
| WO2024233967A2 (en) * | 2023-05-10 | 2024-11-14 | The General Hospital Corporation | Sik inhibitors to treat chronic kidney disease |
| WO2024251187A1 (en) * | 2023-06-06 | 2024-12-12 | Beigene, Ltd. | Benzofuran derivatives as sik inhibitors and use thereof |
| WO2025231112A1 (en) * | 2024-05-01 | 2025-11-06 | Nimbus Salacia, Inc. | Sik2 modulators and uses thereof |
| WO2025231117A1 (en) * | 2024-05-01 | 2025-11-06 | Nimbus Salacia, Inc. | Sik2 modulators and uses thereof |
| WO2025232877A1 (en) * | 2024-05-10 | 2025-11-13 | Insilico Medicine Ip Limited | Salt-inducible kinases (sik) inhibitors |
| WO2025252075A1 (en) * | 2024-06-04 | 2025-12-11 | Insilico Medicine Ip Limited | Novel compounds as salt-inducible kinases inhibitors and uses thereof |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002501532A (ja) * | 1997-05-30 | 2002-01-15 | メルク エンド カンパニー インコーポレーテッド | 新規血管形成阻害薬 |
| US5990146A (en) * | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| US6162804A (en) * | 1997-09-26 | 2000-12-19 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| US6380203B1 (en) * | 1998-01-14 | 2002-04-30 | Merck & Co., Inc. | Angiogenesis inhibitors |
| CA2341409A1 (en) * | 1998-08-31 | 2000-03-09 | Merck And Co., Inc. | Novel angiogenesis inhibitors |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| GB0128499D0 (en) | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| ATE381332T1 (de) * | 2002-05-02 | 2008-01-15 | Merck & Co Inc | Tyrosinkinase-hemmer |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
| EP1641780B1 (en) * | 2003-06-24 | 2008-11-12 | Pfizer Products Incorporated | Processes for the preparation of 1- [(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives |
| WO2006038111A1 (en) * | 2004-10-07 | 2006-04-13 | Pfizer Products Inc. | Benzoimidazole derivatives useful as antiproliferative agents |
| HRP20150642T1 (hr) | 2006-12-22 | 2015-08-14 | Astex Therapeutics Limited | BICIKLIÄŚKE HETEROCIKLIÄŚKE TVARI KAO INHIBITORI FGFR-a |
| JP2010522765A (ja) * | 2007-03-28 | 2010-07-08 | アレイ バイオファーマ、インコーポレイテッド | 受容体チロシンキナーゼとしてのイミダゾ［１，２−ａ］ピリジン化合物 |
| NZ580327A (en) * | 2007-04-03 | 2012-02-24 | Array Biopharma Inc | IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS |
| KR20130059400A (ko) | 2010-08-25 | 2013-06-05 | (주)네오팜 | 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물 |
| US9260426B2 (en) | 2012-12-14 | 2016-02-16 | Arrien Pharmaceuticals Llc | Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors |
| US11998540B2 (en) * | 2015-12-11 | 2024-06-04 | The General Hospital Corporation | Compositions and methods for treating drug-tolerant glioblastoma |
| CN106565704B (zh) | 2016-10-18 | 2018-10-23 | 温州大学 | 一种咪唑并[1,2-a]吡啶的芳基化方法 |
| WO2018136634A1 (en) | 2017-01-18 | 2018-07-26 | Vanderbilt University | Fused heterocyclic compounds as selective bmp inhibitors |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| WO2019081353A1 (de) | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | Substituierte imidazopyridinamide und ihre verwendung |
| EP3717471B1 (en) * | 2017-12-02 | 2022-01-05 | Galapagos NV | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| WO2019155465A1 (en) * | 2018-02-08 | 2019-08-15 | Yeda Research And Development Co. Ltd. | Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction |
| IL257479B (en) | 2018-02-12 | 2022-02-01 | Israel Aerospace Ind Ltd | A radar system and a method for determining the direction of an object |
| MA52873A (fr) * | 2018-06-15 | 2021-04-21 | Galapagos Nv | Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies |
| GB201907616D0 (en) * | 2019-05-29 | 2019-07-10 | Galapagos Nv | Novel compounds and pharmaceutical compositons thereof for the treatment of diseases |
| GB201907558D0 (en) | 2019-05-29 | 2019-07-10 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
| US20240174662A1 (en) | 2021-02-01 | 2024-05-30 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| WO2022165529A1 (en) | 2021-02-01 | 2022-08-04 | Janssen Biotech, Inc. | Small molecule inhibitors of salt inducible kinases |
| CN115197208A (zh) | 2021-04-01 | 2022-10-18 | 江苏恒瑞医药股份有限公司 | 杂芳基类化合物、其制备方法及其在医药上的应用 |
| CN115448881A (zh) | 2021-06-09 | 2022-12-09 | 江苏恒瑞医药股份有限公司 | 杂芳基类化合物、其制备方法及其在医药上的应用 |
-
2021
- 2021-08-05 CN CN202180057654.6A patent/CN116234549B/zh active Active
- 2021-08-05 JP JP2023507619A patent/JP2023536920A/ja active Pending
- 2021-08-05 EP EP25182598.0A patent/EP4660192A1/en active Pending
- 2021-08-05 WO PCT/US2021/044673 patent/WO2022031928A1/en not_active Ceased
- 2021-08-05 AU AU2021320860A patent/AU2021320860A1/en not_active Abandoned
- 2021-08-05 KR KR1020237006438A patent/KR20230049102A/ko active Pending
- 2021-08-05 IL IL300205A patent/IL300205A/en unknown
- 2021-08-05 BR BR112023001952A patent/BR112023001952A2/pt unknown
- 2021-08-05 MX MX2023001236A patent/MX2023001236A/es unknown
- 2021-08-05 US US18/019,527 patent/US12600719B2/en active Active
- 2021-08-05 CA CA3190172A patent/CA3190172A1/en active Pending
- 2021-08-05 EP EP21853415.4A patent/EP4192459A4/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023536920A5 (https=) | ||
| ES2704024T3 (es) | Moduladores P2X7 | |
| AU2022200478B2 (en) | Inhibitors of KEAP1-Nrf2 protein-protein interaction | |
| JP7697954B2 (ja) | Ｋｖ１．３カリウムシェーカーチャネル遮断薬としてのアリールメチレン芳香族化合物 | |
| AU2019255755B2 (en) | STAT3 inhibitors | |
| KR20180120720A (ko) | Wdr5 단백질-단백질 결합의 억제제 | |
| ES3062921T3 (en) | Preparation method for novel rho-related protein kinase inhibitor and intermediate in preparation method | |
| EP3189041A1 (en) | Tetrahydroisoquinoline derived prmt5-inhibitors | |
| WO2014128465A1 (en) | 2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase | |
| WO2016034671A1 (en) | Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived prmt5-inhibitors | |
| WO2014147586A1 (en) | 1-(2-(ethylamino)pyrimidin-4-yl)pyrrolidin-2-ones as inhibitors of mutant idh | |
| WO2014152589A1 (en) | P2x7 modulators | |
| WO2017153518A1 (en) | Prmt5 inhibitors | |
| EP3426351B1 (en) | Benzopiperidine derivatives and their use in the treatment of cancer and hemoglobinopathies | |
| KR20170113629A (ko) | 포유류 티로신 키나제 ROR1 활성의 저해제로서 유용한 2-페닐-3H-이미다조[4,5-b]피리딘 유도체 | |
| AU2025200056B2 (en) | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | |
| WO2017153515A1 (en) | Tetrahydroisoquinolines as prmt5-inhibitors | |
| EP4041714B1 (en) | Bi-aryl dihydroorotate dehydrogenase inhibitors | |
| WO2021240429A1 (en) | Benzofuran and benzopyran dihydroorotate dehydrogenase inhibitors | |
| JP6368043B2 (ja) | 三環式ラクタム化合物の製造法 | |
| JP7083203B2 (ja) | ピラゾロピリミジン誘導体、その用途並びに医薬組成物 | |
| WO2022070071A1 (en) | Dihydroorotate dehydrogenase inhibitors | |
| WO2025099451A1 (en) | New compounds and methods | |
| EA047455B1 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-а]ПИРИДИНИЛА И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ ЗАБОЛЕВАНИЙ | |
| WO2022070069A1 (en) | Dihydroorotate dehydrogenase inhibitors |