JP2023529640A - 治療用コンジュゲート - Google Patents

治療用コンジュゲート Download PDF

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Publication number
JP2023529640A
JP2023529640A JP2022574600A JP2022574600A JP2023529640A JP 2023529640 A JP2023529640 A JP 2023529640A JP 2022574600 A JP2022574600 A JP 2022574600A JP 2022574600 A JP2022574600 A JP 2022574600A JP 2023529640 A JP2023529640 A JP 2023529640A
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Prior art keywords
conjugate
group
dendrimer
targeting agent
lys
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JP2022574600A
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Japanese (ja)
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JP2023529640A5 (enExample
Inventor
ラムナトラオ シェングル，スディール
オーウェン，デビッド
ハフトン，リチャード
テュレヒト，クリス
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スターファーマ ピーティーワイ エルティーディー
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Priority claimed from AU2020901833A external-priority patent/AU2020901833A0/en
Application filed by スターファーマ ピーティーワイ エルティーディー filed Critical スターファーマ ピーティーワイ エルティーディー
Publication of JP2023529640A publication Critical patent/JP2023529640A/ja
Publication of JP2023529640A5 publication Critical patent/JP2023529640A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022574600A 2020-06-03 2021-06-03 治療用コンジュゲート Pending JP2023529640A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020901833 2020-06-03
AU2020901833A AU2020901833A0 (en) 2020-06-03 Therapeutic conjugates
PCT/AU2021/050554 WO2021243415A1 (en) 2020-06-03 2021-06-03 Therapeutic conjugates

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Publication Number Publication Date
JP2023529640A true JP2023529640A (ja) 2023-07-11
JP2023529640A5 JP2023529640A5 (enExample) 2024-06-10

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JP2022574600A Pending JP2023529640A (ja) 2020-06-03 2021-06-03 治療用コンジュゲート

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US (1) US20240293588A1 (enExample)
JP (1) JP2023529640A (enExample)
KR (1) KR20230065935A (enExample)
CN (1) CN115989039A (enExample)
AU (1) AU2021284918A1 (enExample)
CA (1) CA3180877A1 (enExample)
WO (1) WO2021243415A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180326081A1 (en) * 2011-06-06 2018-11-15 Starpharma Pty Ltd Macromolecules
WO2023244828A1 (en) * 2022-06-17 2023-12-21 Purdue Research Foundation Fibroblast activation protein-targeted nanoparticle magnetic resonance imaging agents
WO2024007034A2 (en) * 2022-07-01 2024-01-04 The Johns Hopkins University Dendrimer-delivered alpha-particle radiotherapy for treatment of glioblastoma and other cancers in the brain
EP4661914A1 (en) * 2023-02-09 2025-12-17 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates via inverse electron demand diels-alder reactions
WO2026046228A1 (zh) * 2024-08-27 2026-03-05 苏州拓界医药有限公司 树枝状聚合物偶联物及其制备方法
CN120718105A (zh) * 2025-04-23 2025-09-30 湖南中晟全肽生物科技股份有限公司 一种靶向fgfr2的多肽核素配体、探针及其应用

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