JP2023526277A5 - - Google Patents
Info
- Publication number
- JP2023526277A5 JP2023526277A5 JP2022569012A JP2022569012A JP2023526277A5 JP 2023526277 A5 JP2023526277 A5 JP 2023526277A5 JP 2022569012 A JP2022569012 A JP 2022569012A JP 2022569012 A JP2022569012 A JP 2022569012A JP 2023526277 A5 JP2023526277 A5 JP 2023526277A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- conjugate product
- linker
- product according
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063024142P | 2020-05-13 | 2020-05-13 | |
| US63/024,142 | 2020-05-13 | ||
| PCT/US2021/031903 WO2021231518A1 (en) | 2020-05-13 | 2021-05-12 | Nucleic acid ligand conjugates and use thereof for delivery to cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023526277A JP2023526277A (ja) | 2023-06-21 |
| JP2023526277A5 true JP2023526277A5 (https=) | 2024-05-17 |
Family
ID=78524924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022569012A Pending JP2023526277A (ja) | 2020-05-13 | 2021-05-12 | 核酸リガンドコンジュゲートおよび細胞への送達のためのその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230285579A1 (https=) |
| EP (1) | EP4149557A4 (https=) |
| JP (1) | JP2023526277A (https=) |
| CN (2) | CN115697416A (https=) |
| CA (1) | CA3174467A1 (https=) |
| WO (1) | WO2021231518A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024102864A2 (en) * | 2022-11-08 | 2024-05-16 | Purdue Research Foundation | Multivalent multispecific conjugates and related compositions and methods of use |
| EP4687988A2 (en) * | 2023-03-28 | 2026-02-11 | KIST (Korea Institute of Science and Technology) | Therapeutic compounds for inhibiting and reducing the expression of cell surface proteins |
| CN117865868B (zh) * | 2023-05-19 | 2024-09-06 | 湖南大学 | 一种功能化分子、其制备方法及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904582A (en) * | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| WO2008079973A2 (en) * | 2006-12-21 | 2008-07-03 | Centocor, Inc. | Egfr binding peptides and uses thereof |
| WO2009002440A2 (en) * | 2007-06-22 | 2008-12-31 | Intradigm Corporation | Compositions comprising human egfr-sirna and methods of use |
| RU2010107199A (ru) * | 2007-07-31 | 2011-09-10 | Дзе Джонс Хопкинс Юниверсити (Us) | Конъюгат полипептид-нуклеиновая кислота для иммунопрофилактики или иммунотерапии для неопластических или инфекционных нарушений |
| GB0814960D0 (en) * | 2008-08-15 | 2008-09-24 | Ge Healthcare As | Method for detecting dysplasia |
| CN105722851A (zh) * | 2013-04-28 | 2016-06-29 | 秦刚 | 一种新型的连接子及其制备方法和用途 |
| WO2017127473A1 (en) * | 2016-01-19 | 2017-07-27 | The University Of North Carolina At Chapel Hill | Methods and compositions using rna interference for inhibition of kras |
| CN109641038A (zh) * | 2016-07-01 | 2019-04-16 | 小利兰·斯坦福大学理事会 | 靶向细胞表面编辑的共轭物 |
| SG11201906728TA (en) * | 2017-02-06 | 2019-08-27 | Mpeg La Llc | Multimeric oligonucleotides having decreased kidney clearance |
| US20200002746A1 (en) * | 2017-02-14 | 2020-01-02 | Seqwell, Inc. | Compositions and methods for sequencing nucleic acids |
| KR102353086B1 (ko) * | 2018-09-07 | 2022-01-20 | 아주대학교산학협력단 | 신규 면역독소 제조방법 |
| JP7839554B2 (ja) * | 2020-04-07 | 2026-04-02 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | Ｋｒａｓの阻害のためのｒｎａ干渉およびアンチセンスオリゴヌクレオチドを使用する方法および組成物 |
-
2021
- 2021-05-12 EP EP21803204.3A patent/EP4149557A4/en active Pending
- 2021-05-12 CA CA3174467A patent/CA3174467A1/en active Pending
- 2021-05-12 CN CN202180037230.3A patent/CN115697416A/zh active Pending
- 2021-05-12 WO PCT/US2021/031903 patent/WO2021231518A1/en not_active Ceased
- 2021-05-12 US US17/997,398 patent/US20230285579A1/en active Pending
- 2021-05-12 JP JP2022569012A patent/JP2023526277A/ja active Pending
- 2021-05-12 CN CN202610037779.7A patent/CN121775155A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10041071B2 (en) | Cell-type specific aptamer-siRNA delivery system for HIV-1 therapy | |
| ES3034830T3 (en) | High-efficiency nanoparticle-type double-helical oligo-rna structure and method for preparing same | |
| CN105705638B (zh) | 改善的具有高效能的纳米颗粒型寡核苷酸结构及其制备方法 | |
| US9267150B2 (en) | Supercoiled minicircle DNA for gene therapy applications | |
| JP2023526277A5 (https=) | ||
| Yu et al. | Improved method for synthesis of low molecular weight protamine–siRNA conjugate | |
| Tripathy et al. | Nanobody-oligonucleotide conjugates (NucleoBodies): the next frontier in oligonucleotide therapy | |
| CN116157521A (zh) | 双链寡核苷酸和用于治疗covid-19的含有其的组合物 | |
| US20240384269A1 (en) | Compositions containing nucleic acid nanoparticles and processes related to alteration of their physiochemical characteristics | |
| US20130108686A1 (en) | Method for the delivery of oligonucleotides | |
| WO2012173994A2 (en) | Phase changing formulations of nucleic acid payloads | |
| Peng et al. | Designing nucleic acid-based therapeutics for cancer treatment: Updates on the state of the art | |
| JP6795492B2 (ja) | ＣＬＣＮ７（ＡＤＯ２ ＣＬＣＮ７依存性）遺伝子変異によって引き起こされる常染色体優性大理石骨病２型（ＡＤＯ２）療法のための短鎖干渉ＲＮＡ（ｓｉＲＮＡ） | |
| US20260015618A1 (en) | Therapeutic Compounds for Red Blood Cell-Mediated Delivery of an Active Pharmaceutical Ingredient to a Target Cell | |
| Amaya | Advancing RNA Therapeutics: Regulation, Immunogenicity, and Delivery | |
| EP4704858A1 (en) | Sugar modified oligonucleotides and uses thereof | |
| WO2025019860A1 (en) | Oligonucleotide constructs with improved function and therapeutics | |
| JP2026509931A (ja) | 完全修飾ｍｉＲ－３４ａおよび関連コンジュゲート、組成物および使用方法 |