JP2023526259A - がんまたは腫瘍の治療の方法 - Google Patents

がんまたは腫瘍の治療の方法 Download PDF

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JP2023526259A
JP2023526259A JP2022568820A JP2022568820A JP2023526259A JP 2023526259 A JP2023526259 A JP 2023526259A JP 2022568820 A JP2022568820 A JP 2022568820A JP 2022568820 A JP2022568820 A JP 2022568820A JP 2023526259 A JP2023526259 A JP 2023526259A
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cancer
cells
seq
tumor
amino acid
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JP2023526259A5 (https=
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エドワード ダッドリー，マーク
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アダプティミューン・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/51—Stomach
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
JP2022568820A 2020-05-13 2021-05-13 がんまたは腫瘍の治療の方法 Pending JP2023526259A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063024104P 2020-05-13 2020-05-13
US63/024,104 2020-05-13
PCT/GB2021/051158 WO2021229235A1 (en) 2020-05-13 2021-05-13 Method of treatment of cancer or tumour

Publications (2)

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JP2023526259A true JP2023526259A (ja) 2023-06-21
JP2023526259A5 JP2023526259A5 (https=) 2025-03-27

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JP2022568820A Pending JP2023526259A (ja) 2020-05-13 2021-05-13 がんまたは腫瘍の治療の方法

Country Status (7)

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US (1) US20230190802A1 (https=)
EP (1) EP4149631A1 (https=)
JP (1) JP2023526259A (https=)
CN (1) CN116194472A (https=)
AU (1) AU2021270378A1 (https=)
CA (1) CA3178588A1 (https=)
WO (1) WO2021229235A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2023010541A (es) 2021-03-09 2023-11-24 Cdr Life Ag Proteinas de union al antigeno del peptido del mhc mage-a4.
US12435444B2 (en) 2021-03-09 2025-10-07 Cdr-Life Ag Rabbit-derived antigen binding protein nucleic acid libraries and methods of making the same
GB202205572D0 (en) * 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
CN116449016A (zh) * 2022-08-26 2023-07-18 成都益安博生物技术有限公司 一种食管癌的外周血tcr标志物序列及其检测试剂盒和应用
GB202213050D0 (en) * 2022-09-07 2022-10-19 Adaptimmune Ltd Method of treatment of gastroesophageal cancer
CA3264474A1 (en) 2022-09-14 2024-03-21 Cdr-Life Ag MAGE-A4 DOUBLE T LYMPHOCYTE ENGAGEMENT
EP4659024A1 (en) * 2023-01-31 2025-12-10 Agilent Technologies, Inc. Immunohistochemistry (ihc) mage-a4 scoring protocols and methods for aiding cancer treatments
CN120594199B (zh) * 2025-08-06 2025-11-07 浙江省肿瘤医院 Mhc-ii表达在胃癌免疫治疗疗效预测中的用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019528748A (ja) * 2016-09-23 2019-10-17 アダプティミューン・リミテッド 免疫抑制抵抗性が増したｔ細胞
WO2020049496A1 (en) * 2018-09-05 2020-03-12 Glaxosmithkline Intellectual Property Development Limited T cell modification
JP2020509767A (ja) * 2017-03-15 2020-04-02 フレッド ハッチンソン キャンサー リサーチ センター 高親和性ｍａｇｅ−ａ１特異的ｔｃｒ及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201819540D0 (en) * 2018-11-30 2019-01-16 Adaptimmune Ltd T cell modification
WO2021144338A1 (en) * 2020-01-14 2021-07-22 Adaptimmune Limited Method of treatment of cancer or tumour

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019528748A (ja) * 2016-09-23 2019-10-17 アダプティミューン・リミテッド 免疫抑制抵抗性が増したｔ細胞
JP2020509767A (ja) * 2017-03-15 2020-04-02 フレッド ハッチンソン キャンサー リサーチ センター 高親和性ｍａｇｅ−ａ１特異的ｔｃｒ及びその使用
WO2020049496A1 (en) * 2018-09-05 2020-03-12 Glaxosmithkline Intellectual Property Development Limited T cell modification

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"Enhanced activity of second-generation MAGE-A4 SPEAR T-cells through co-expression of a CD8α homodi", CANCER RES., vol. Vol.79, No.13_Supplement, JPN6025031524, 2019, pages 2313, ISSN: 0005656762 *
"Initial safety assessment of MAGE-A4 SPEAR T-cells", IMMUNOTHERAPY OF CANCER, vol. Vol.29, Suppl.8, JPN6025031523, 2018, pages 412 - 1156, ISSN: 0005656763 *
J. CLIN. MED., vol. Vol.5, No.84, doi:10.3390/jcm5100084, JPN6025031522, 2016, pages 1 - 14, ISSN: 0005656761 *
ONCOIMMUNOLOGY, vol. Vol.9, No.1, e1682381, JPN6025031525, 24 November 2019 (2019-11-24), pages 1682381 - 1, ISSN: 0005656760 *

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Publication number Publication date
AU2021270378A1 (en) 2022-12-15
WO2021229235A1 (en) 2021-11-18
EP4149631A1 (en) 2023-03-22
CN116194472A (zh) 2023-05-30
US20230190802A1 (en) 2023-06-22
CA3178588A1 (en) 2021-11-18

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