JP2023523211A - 眼科遺伝子治療後の、導入遺伝子産物を発現する形質転換細胞に対する免疫応答の誘導を防止するための方法 - Google Patents

眼科遺伝子治療後の、導入遺伝子産物を発現する形質転換細胞に対する免疫応答の誘導を防止するための方法 Download PDF

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JP2023523211A
JP2023523211A JP2022563882A JP2022563882A JP2023523211A JP 2023523211 A JP2023523211 A JP 2023523211A JP 2022563882 A JP2022563882 A JP 2022563882A JP 2022563882 A JP2022563882 A JP 2022563882A JP 2023523211 A JP2023523211 A JP 2023523211A
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transgene
vector
aav
peptide
subretinal
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JPWO2021214282A5 (https=
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シルヴァン，フィソン
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Institut National de la Sante et de la Recherche Medicale INSERM
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    • C12N2750/14011—Parvoviridae
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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JP2022563882A 2020-04-24 2021-04-23 眼科遺伝子治療後の、導入遺伝子産物を発現する形質転換細胞に対する免疫応答の誘導を防止するための方法 Pending JP2023523211A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP20315217.8 2020-04-24
EP20315217 2020-04-24
EP20305407 2020-04-27
EP20305407.7 2020-04-27
PCT/EP2021/060647 WO2021214282A1 (en) 2020-04-24 2021-04-23 Methods for preventing induction of immune responses to the transduced cells expressing a transgene product after ocular gene therapy

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JP2023523211A true JP2023523211A (ja) 2023-06-02
JPWO2021214282A5 JPWO2021214282A5 (https=) 2024-02-08
JP2023523211A5 JP2023523211A5 (https=) 2024-02-08

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US (1) US20230190956A1 (https=)
EP (1) EP4138929A1 (https=)
JP (1) JP2023523211A (https=)
CA (1) CA3179895A1 (https=)
WO (1) WO2021214282A1 (https=)

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WO2026005189A1 (ko) * 2024-06-27 2026-01-02 이엔셀 주식회사 안구 세포 또는 조직을 표적하는 펩타이드 및 이를 포함하는 바이러스 캡시드 단백질 및 바이러스 벡터

Citations (1)

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WO2009105690A2 (en) * 2008-02-21 2009-08-27 Targeted Genetics Corporation Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea

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US5639872A (en) 1993-07-27 1997-06-17 Hybridon, Inc. Human VEGF-specific oligonucleotides
WO1997020925A1 (en) 1995-12-08 1997-06-12 Hybridon, Inc. Modified vegf antisense oligonucleotides for treatment of skin disorders
US20030144221A1 (en) 2001-07-17 2003-07-31 Isis Pharmaceuticals Inc. Antisense modulation of BCL2-associated X protein expression
DK2359869T3 (en) 2001-12-17 2019-04-15 Univ Pennsylvania Sequences of adeno-associated virus (AAV) serotype 8, vectors containing these, and uses thereof
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
AU2005222902B2 (en) 2004-03-12 2010-06-10 Alnylam Pharmaceuticals, Inc. iRNA agents targeting VEGF
EP1919497B1 (en) 2005-07-22 2020-02-12 The Board of Trustees of the Leland Stanford Junior University Light-activated cation channel and uses thereof
EP2019588A4 (en) 2006-05-04 2010-11-24 Univ Wayne State RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
US7872118B2 (en) 2006-09-08 2011-01-18 Opko Ophthalmics, Llc siRNA and methods of manufacture
HRP20171334T1 (hr) 2011-04-22 2017-11-17 The Regents Of The University Of California Virioni adeno-povezanog virusa s kapsid varijantom i postupci njihove upotrebe
JP6348064B2 (ja) * 2011-11-22 2018-06-27 ザ チルドレンズ ホスピタル オブ フィラデルフィア 効率の高いトランスジーン送達のためのウイルスベクター
ES2908467T3 (es) * 2016-04-29 2022-04-29 Adverum Biotechnologies Inc Evasión de anticuerpos neutralizantes por un virus adenoasociado recombinante

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WO2009105690A2 (en) * 2008-02-21 2009-08-27 Targeted Genetics Corporation Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea

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MINGOZZI F. ET AL.: "Overcoming preexisting humoral immunity to AAV using capsid decoys", SCI TRANSL MED. AUTHOR MANUSCRIPT, NIH PUBLIC ACCESS, JPN6025004057, 14 July 2014 (2014-07-14), pages 1 - 20, ISSN: 0005651343 *

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US20230190956A1 (en) 2023-06-22
CA3179895A1 (en) 2021-10-28
WO2021214282A1 (en) 2021-10-28
EP4138929A1 (en) 2023-03-01

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