JP2023520987A - Pest control composition containing elemental sulfur and anthranilic diamide insecticide - Google Patents

Abstract

The present invention relates to pest control compositions comprising elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable excipient. The present invention particularly presents elemental sulfur in the range of 40% w/w to 95% w/w of the total composition and in the range of 0.1% w/w to 3% w/w of the total composition. , cyantraniliprole, tetraniliprole, cyclaniliprole, tetrachlorantraniliprole, and chlorantraniliprole, and at least one agricultural and a chemically acceptable excipient. The invention is either in the form of a liquid suspension, water-dispersible granules, or spheroidized granules. The granule composition has a granule size ranging from 0.1 mm to 6 mm, and the granules are dispersed into particles ranging in size from 0.1 micron to 50 microns. Liquid suspension compositions have particles ranging in size from 0.1 microns to 50 microns. The present invention also relates to processes for preparing pesticidal compositions.

Description

The present invention relates to pest control compositions comprising elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable excipient. The present invention particularly presents elemental sulfur in the range of 40% w/w to 95% w/w of the total composition and in the range of 0.1% w/w to 3% w/w of the total composition. , cyantraniliprole, tetraniliprole, cyclaniliprole, tetrachlorantraniliprole, and chlorantraniliprole, and at least one agricultural and a chemically acceptable excipient. The pest control composition is in the form of granules or liquid suspensions. Granules are either water-dispersible granules or spheroidized granules. Additionally, the pest control composition comprises granules ranging in size from 0.1 mm to 6 mm, dispersed into particles ranging in size from 0.1 microns to 50 microns. The liquid suspension compositions of the present invention have particles ranging in size from 0.1 microns to 50 microns.

The present invention further relates to processes for preparing pest control compositions.

In describing embodiments of the present invention, specific terminology is chosen for clarity. However, it is not intended that the invention be limited to the specific terms so selected, and that each specific term covers all technical terms that operate in a similar manner to accomplish a similar purpose. It should be understood to include equivalents.

The pesticidal efficacy of known compounds is unsatisfactory, for example in the area of pest control. Due to diverse practices in different areas, pesticides are sometimes administered at relatively high dosages, which ultimately lead to the development of resistance among the pests, thereby leading to higher In addition to economic costs, it leads to soil toxicity and other environmental hazards.

Current pesticidal combinations available are old chemistries and repeated use of such chemical combinations can lead to problems such as pesticide resistance, pest resurgence, secondary pest outbreaks, residue-related problems, and toxic effects on humans. , and caused problems in pest community management such as yield reduction. Therefore, there is a need for new combinations that broaden the spectrum of activity, provide less intolerable toxicity, and better enhance plant health and yield. Accordingly, there is an increasing demand for insecticidal compounds with reduced phytotoxicity, reduced dosage, substantially broadened spectrum, and increased safety to humans and the environment, to name a few.

Limiting the substantial use of chemical pesticides and identifying pesticidal compositions effective at low doses would reduce toxicity without causing cross-resistance to existing products, and would also be environmentally friendly. This is of great importance in today's world striving towards chemical-free pesticides with reduced dependence on chemicals. Therefore, it is economical and effective in terms of insect control, yield, plant growth, broader crop protection spectrum, reduced number of applications, reduced environmental/farmer burden, healthy foliage, labor cost savings, and still the end user. There is a continuing need for new pesticide combinations that are applied to provide cost-effective solutions to pesticides.

Diamide insecticides (such as anthranilic diamides) are a new class of insecticides that provide good control through their action on a novel target, the ryanodine receptor. Anthranilic diamides can activate this receptor, causing the release of stored calcium from the sarcoplasmic reticulum, causing dysregulation of muscle contraction and thus cell death.

The role and benefits of sulfur as a pesticide have long been known. Sulfur is judged to be organic in nature, and much is available in its elemental form. The benefits of using sulfur not only encompass reduced reliance on chemical use as an effective mode of pest control, but being organic in nature is also environmentally friendly and increases yields. improve food safety, human, animal or plant health and quality of life. Different formulations (such as granules, pellets, and powders) are known to provide sulfur in a form used as a fertilization agent or pesticide. The use of sulfur as a fungicide, acaricide and acaricide is of particular importance and has long been used as an environmentally friendly mode of farming.

Pest control compositions containing diamide pesticides and fungicides such as dithiocarbamates are known in the art, but there is no disclosure of combinations containing diamide pesticides and sulfur.

US Pat. No. 5,300,000 relates to combinations of diamide insecticides with at least one fungicidally active compound and another insecticidal compound. It discloses that the pest control composition is effective in controlling target pests due to the use of a triple combination comprising diamide pesticides, dithiocarbamates, and other pesticides. US Pat. No. 6,301,003 relates to combinations of diamide insecticides with at least one multisite fungicide compound and at least one second fungicidal compound. It is effective in controlling target pests due to the use of a triple combination in which the pest control composition comprises diamide insecticides, dithiocarbamate fungicides, and other fungicidal compounds. Disclose that These applications are silent on the effectiveness and synergy of specific combinations of elemental sulfur and anthranilic diamide pesticides in pesticidal effective amounts.

US Pat. No. 5,300,005 describes an agricultural composition containing sulfur present in a ratio of 0.1 to 200:1 and 1 or 2 further pesticidal actives to control various crop diseases and pests. about things. It states that the pesticidal actives can be either acaricides, fungicides, insecticides, or combinations thereof, and provides a detailed list of pesticidal actives. Patent Document 4 discloses fertilization mediators, pesticides (such as pymetrozine and chlorantraniliprole), sustained release agents together with dispersion media for pest control, and sustained release of nutritional supplements in paddy fields. It relates to a sexual granule composition. These applications do not mention the specific combination of elemental sulfur and an anthranilic diamide pesticide in a pesticidal effective amount.

Thus, the specificity of sulfur and anthranilic diamide pesticides that can be effectively used with broad-spectrum pesticidal activity at lower dosages and that can address the above-discussed shortcomings of known compositions. No specific pest control composition containing a combination of these is known or available.

Elemental sulfur is a specific particle size and an effective amount of anthranilic diamide pesticides (including cyantraniliprole, tetraniliprole, cyclaniliprole, tetrachlorantraniliprole, chlorantraniliprole) was found by the inventors to be synergistic in nature and demonstrate excellent field efficacy when combined with Synergy is also demonstrated by the fact that the combination is effective even at very low doses of anthranilic dimaide insecticide.

Sulfur is an essential active ingredient present in the composition and in combination with the anthranilic diamide pesticide used in concentrations as low as 0.1% to 3% w/w of the total composition. is used at higher concentrations of about 40% w/w to 95% w/w of, offering a more sustainable and ecological approach in agriculture and nutrition for crop protection.

Surprisingly, higher loadings of sulfur in combination with chemical pesticides help reduce dependence on chemical pesticides, further reducing induced toxicity to the environment and humans, It was observed to reduce the chances of resistance in pests/insects, avoid subsequent use of chemicals, and promote better plant health and yield.

In addition to the synergistic effect of the compositions of the present invention, the inventors have found that compositions comprising elemental sulfur and an anthranilic diamide pesticide in an effective amount in the form of a liquid suspension or granules are superior pest control agents. It has been surprisingly determined that control is provided and yield is improved when the particles in the composition are present in the size range of 0.1 microns to 50 microns.

The inventors have found that the optimal product type to provide such an organic and ecological combination of elemental sulfur and an effective amount of anthranilic diamide pesticide is a liquid suspension or granules, which are active substances has been found to help provide stable and user-friendly formulations by minimizing the loss of Combinations of pesticides in the form of liquid suspensions and granules with particle sizes ranging from 0.1 microns to 50 microns are suspendable, dispersible upon application via soil or foliar routes. It also facilitates the physical properties of the formulation by providing improved, improved viscosity, immediate dispersion of the active, which provides effective control of the target pest.

International Patent Application Publication No. 2018/224915 International Patent Application Publication No. 2018224914 pamphlet China Patent No. 103355343 China Patent No. 108911893

Accordingly, the inventors of the present invention have found elemental sulfur ranging from 40% w/w to 95% w/w of the total composition and at least one anthranilic diamide pesticide selected from the group consisting of at least one of cyantraniliprole, tetraniliprole, cyclaniliprole, tetrachlorantraniliprole, and chlorantraniliprole in scope; and at least one agrochemically acceptable excipient, wherein the particles are between 0.1 microns and 50 microns. Said compositions were developed, which exist in a range of sizes. The pest control composition is synergistic in nature, providing crop protection and nutrition at reduced dosages. The composition has a granule size ranging from 0.1 mm to 6 mm and is dispersed into particles having a size range from 0.1 microns to 50 microns. The pest control composition of the present invention not only obviates the associated drawbacks as pointed out in the preceding paragraph, but is also a superior composition that would otherwise be difficult to achieve in a cost effective manner. offer.

The present invention provides elemental sulfur in the range of 40% w/w to 95% w/w of the total composition and at least 1 1. A pest control composition comprising one anthranilic diamide pesticide and at least one agrochemically acceptable excipient, wherein the composition is in the form of water dispersible granules or spheroidized granules. wherein the granule size ranges from 0.1 mm to 6 mm, the granules being dispersed into particles ranging in size from 0.1 micron to 50 microns.

The present invention provides elemental sulfur in the range of 40% w/w to 95% w/w of the total composition and at least one sulfur in the range of 0.1% w/w to 3% w/w of the total composition. A liquid suspension pesticide composition comprising a tranilic diamide insecticide and at least one agrochemical excipient, wherein the composition has a particle size in the range of 0.1 microns to 50 microns. There is, it relates to the composition.

The present invention is a process for preparing a granular pesticidal composition in water-dispersible form comprising: a) combining an admixture of elemental sulfur and at least one anthranilic diamide pesticide with at least one agrochemical grinding with excipients to obtain a slurry or wet mixture; b) drying the wet mixture to obtain a water dispersible granular composition, the granules of the composition having a size range of 0.1 to 2.5 mm; and comprising granules of

The present invention is a process for preparing a granular pesticidal composition in the form of spheroidized granules comprising: a) combining an admixture of elemental sulfur and at least one anthranilic diamide pesticide with at least one agrochemical grinding with excipients to obtain a slurry or wet mixture; b) drying the wet mixture to obtain a granular composition, wherein the granules of the composition are from granules in the size range of 0.1 to 2.5 mm; and c) adding water to the dry powder and kneading the mixture to obtain a dough or paste, which is then extruded through an extruder to obtain extruded granules in the size range of 0.1 mm to 6 mm. or agglomerating the wet mixture or dry powder obtained in step (b) in an agglomerator to obtain a granular composition in the size range of 0.1 mm to 6 mm. related.

The present invention is a process for the preparation of a liquid suspended pesticide composition comprising a mixture of elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable excipient. homogenizing to obtain a suspension; and wet milling the resulting suspension to provide a composition with a particle size range of 0.1 microns to 50 microns. related.

In describing embodiments of the present invention, specific terminology is chosen for clarity. However, it is not intended that the invention be limited to the specific terms so selected, and that such specific terms cover all technical equivalents that operate in a similar manner to accomplish a similar purpose. It should be understood to include objects. It should be understood that any numerical range recited herein is intended to include all subranges subsumed. Also, unless otherwise indicated, percentages of components in the composition are given as weight percent.

Sulfur as used in the composition refers to elemental sulfur.

Granules mainly refer to water dispersible granules, extruded granules or spheroidized granules.

Water-dispersible granules are defined as formulations that, when added to water, rapidly disperse or dissolve to give a fine particle suspension. As described herein, "WG" or "WDG" refers to water-dispersible granules. As described herein, "GR" refers to extruded granules or spheronized granules.

Liquid suspensions encompass "aqueous suspension" or "aqueous dispersion" or "suspension concentrate (SC)" compositions. A liquid suspension is defined as a composition in which solid particles are dispersed or suspended in a liquid. The liquid as vehicle can be water and/or a water-miscible solvent.

The present invention relates to pest control compositions comprising elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable excipient.

The present invention provides elemental sulfur in the range of 40% w/w to 95% w/w of the total composition and at least 1 pest control compositions comprising one anthranilic diamide pesticide and at least one agrochemical excipient.

The pesticidal compositions of the present invention are in the form of granules or liquid suspensions.

Granular pest control compositions are in the form of either water-dispersible granules or spheroidized granules.

The granular composition has granules ranging in size from 0.1 mm to 6 mm dispersed into particles ranging in size from 0.1 microns to 50 microns.

The liquid suspension composition also has particles ranging in size from 0.1 microns to 50 microns.

According to one embodiment elemental sulfur is present in the range of 40% w/w to 95% w/w of the total composition. According to one embodiment elemental sulfur is present in the range of 40% w/w to 90% w/w of the total composition. According to one embodiment elemental sulfur is present in the range of 40% w/w to 80% w/w of the total composition. According to one embodiment elemental sulfur is present in the range of 40% w/w to 70% w/w of the total composition. According to one embodiment elemental sulfur is present in the range of 40% w/w to 60% w/w of the total composition. According to one embodiment elemental sulfur is present in the range of 40% w/w to 50% w/w of the total composition.

According to one embodiment, the at least one anthranilic diamide pesticide is especially from the group consisting of cyantraniliprole, tetraniliprole, cyclaniliprole, tetrachlorantraniliprole, and chlorantraniliprole selected.

According to one embodiment, the at least one anthranilic diamide pesticide is present in the range of 0.1% w/w to 3% w/w of the total composition. According to one embodiment, the at least one anthranilic diamide pesticide is present in the range of 0.1% w/w to 2% w/w of the total composition. According to one embodiment, the at least one anthranilic diamide pesticide is present in the range of 0.1% w/w to 1.5% w/w of the total composition. According to one embodiment, the at least one anthranilic diamide pesticide is present in the range of 0.1% w/w to 1% w/w of the total composition.

According to a further embodiment, the particle size of the liquid suspension composition ranges from 0.1 microns to 50 microns. According to a further embodiment, the particle size of the liquid suspension composition ranges from 0.1 microns to 30 microns. According to a further embodiment, the particle size of the liquid suspension composition ranges from 0.1 microns to 25 microns. According to a further embodiment, the particle size of the liquid suspension composition ranges from 0.1 microns to 20 microns. According to a further embodiment, the particle size of the liquid suspension composition ranges from 0.1 microns to 10 microns.

According to one embodiment, the pesticidal composition is in the form of spheronized granules, the granules having a size range of 0.1-6 mm, preferably a size range of 0.1-5 mm, preferably 0.1 -4 mm size range, preferably 0.1-3 mm size range, preferably 0.1-2.5 mm size range. The granules are dispersed into particles ranging in size from 0.1 microns to 50 microns.

According to one embodiment, the pesticidal composition is in the form of water-dispersible granules, the granules having a size range of 0.1-2.5 mm, preferably a size range of 0.1-2 mm, preferably The size range is from 0.1 to 1.5 mm, preferably from 0.1 to 1 mm, preferably from 0.1 to 0.5 mm. The granules are dispersed into particles ranging in size from 0.1 microns to 50 microns, preferably from 0.1 microns to 20 microns.

According to one embodiment, the pest control composition comprises at least one agrochemically acceptable excipient. According to a further embodiment, the agrochemically acceptable excipients are surface-active substances, binding substances or binding agents, disintegrating agents, filling substances or carriers or diluent substances, coating agents, buffer substances or pH adjusting substances or neutralizers, defoamers or foam inhibitors, penetrating substances, UV-absorbing substances, UV-scattering agents, stabilizing substances, pigments, coloring substances, structuring agents, chelating or complexing agents or sequestering agents, thickeners substances, suspending agents or suspending aids or anti-caking agents or anti-settling agents, viscosity modifiers or rheology modifiers, tackifying substances, moisturizing substances, sticking agents, antifreeze agents or freezing point lowering substances, water miscible solvents, and mixtures thereof. However, those skilled in the art will recognize that additional agrochemically acceptable excipients can be utilized without departing from the scope of the invention.

According to one embodiment, the pest control composition in the form of water-dispersible granules or spheronized granules further comprises at least one agrochemical excipient, which excipients include disintegrant, Surfactants, binders or fillers or carriers or diluents, defoamers, UV-absorbing substances, UV-scattering agents, anti-caking agents or anti-settling substances or suspending aids or suspending agents, penetrating agents, sticking agents , tackifying substances, pigments, coloring substances and stabilizing substances. However, those skilled in the art will recognize that additional agrochemically acceptable excipients can be utilized without departing from the scope of the invention.

According to one embodiment, the liquid pesticidal composition further comprises at least one agrochemical excipient, including at least one structuring agent, surfactant, moisturizing agent, water-miscible solvents, suspending agents or suspension aids or anti-caking or anti-settling agents, penetrating agents, sticking agents, UV-absorbing substances, UV-scattering agents, buffering substances or pH adjusting substances or neutralizing agents, stabilizing agents substances, antifreeze or freezing point lowering substances, antifoaming agents. However, those skilled in the art will recognize that additional agrochemically acceptable excipients can be utilized without departing from the scope of the invention.

According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 95% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 10% w/w to 95% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 80% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 70% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 60% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 50% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 40% w/w of the total composition. According to one embodiment, the agrochemically acceptable excipient is present in the range of 5% w/w to 30% w/w of the total composition.

According to one embodiment, surface-active substances include one or more of emulsifying substances, wetting agents, and dispersing agents. According to one embodiment, the surfactants used in the pesticidal composition include anionic surfactants, cationic surfactants, nonionic surfactants, amphoteric surfactants, and One or more of polymeric surfactants are included.

Examples of anionic surfactants include salts of fatty acids, benzoates, polycarboxylates, salts of alkyl sulfates, alkyl ether sulfates, alkyl sulfates, alkylaryl sulfates, alkyl diglycol ether sulfates, and alcohols. sulfate salts, alkylsulfonates, alkylarylsulfonates, arylsulfonates, ligninsulfonates, alkyldiphenyl ether disulfonates, polystyrenesulfonates, salts of alkylphosphates, alkylarylphosphates, styrylaryl phosphate, sulfonate docusate, salt of polyoxyethylene alkyl ether sulfate, polyoxyethylene alkyl aryl ether sulfate, alkyl sarcosinate, α-olefin sulfonate sodium salt, alkylbenzene sulfonate or its salt, Sodium lauroyl sarcosinate, sulfosuccinates, polyacrylates, polyacrylates - free acid and sodium salts, salts of polyoxyethylene alkyl aryl ether sulfates, polyoxyethylene alkyl ether phosphates, polyoxyethylene alkyl aryl Salts of phosphate esters, sulfosuccinate-monoesters and other diesters, phosphate esters, alkylnaphthalenesulfonates-isopropyl and butyl derivatives, alkyl ether sulfates-sodium and ammonium salts; alkylaryl ether phosphates , ethylene oxide and its derivatives, salts of polyoxyethylene aryl ether phosphates, mono-alkyl sulfosuccinates, aromatic hydrocarbon sulfonates, 2-acrylamido-2-methylpropanesulfonic acid, ammonium lauryl sulfate, ammonium perfluorononanoate , Docusate, Disodium Cocoamphodiacetate, Magnesium Laureth Sulfate, Perfluorobutanesulfonic Acid, Perfluorononanoic Acid, Carboxylates, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, Phospholipids, Potassium Lauryl Sulfate, Soap, Soap Substitute, Sodium Alkyl Sulfate, Sodium dodecyl sulfate, sodium dodecylbenzene sulfonate, sodium laurate, sodium laureth sulfate, sodium lauroyl sarcosinate, sodium myreth sulfate, sodium nonanoyloxybenzene sulfonate, alkyl carboxylate, sodium stearate, alpha olefin sulfonate, Naphthalene sulfonates, alkylnaphthalene sulfonic acid fatty acid salts, naphthalene sulfonate condensates-sodium salts, fluorocarboxylates, fatty alcohol sulfates, alkylnaphthalene sulfonate condensates-sodium salts, naphthalene sulfones condensed with formaldehyde Acids, or salts of alkylnaphthalenesulfonic acids condensed with formaldehyde; or salts, derivatives thereof, one or more of these.

Cationic surfactants include dialkyldimethylammonium chloride, alkylmethylethoxylated ammonium chloride or salts, dodecyl-, coco-, hexadecyl-, octadecyl-, octadecyl/behenyl-, behenyl-, cocoamidopropyl-, trimethyl chloride. ammonium; coco-, stearyl-, bis(2-hydroxyethyl)methylammonium chloride, benzalkonium chloride, alkyl-, tetradecyl-, octadecyl-dimethylbenzyl ammonium chloride, dioctyl-, di(octyl-decyl)-, didecyl- , dihexadecyl-distearyl-, di(hydrogenated tallow)-dimethylammonium chloride, di(hydrogenated tallow)benzyl-, trioctyl-, tri(octyl-decyl), tridodecyl, trihexadecyl-methylammonium chloride, dodecyltrimethyl- , dodecyldimethylbenzyl-, di-(octyl-decyl)dimethyl, didecyldimethyl-ammonium bromide, quaternary amine ethoxylates, behentrimonium chloride, benzalkonium chloride, benzethonium chloride, benzododecinium bromide, Bronidox, quaternary ammonium salts, carbetopendecinium bromide, cetalconium chloride, cetrimonium bromide, cetrimonium chloride, cetylpyridium chloride, didecyldimethylammonium chloride, dimethyldioctadecyl ammonium bromide, dimethyldiotadecyl chloride ammonium, domiphene bromide, lauryl methyl gluceth-10 hydroxypropyldimonium chloride, octenidine dihydrochloride, olaflur, N-oleyl 1,3-propanediamine, pufftoxin, stearalkonium chloride, tetramethylammonium hydroxide , tonzonium bromide; one or more of salts or derivatives thereof.

Nonionic surfactants include polyol esters, polyol fatty acid esters, polyethoxylated esters, polyethoxylated alcohols, ethoxylated propoxylated fatty alcohols, ethoxylated propoxylated alcohols, ethylene oxide (EO)/propylene oxide (PO) copolymers; and PO block copolymers, diblock copolymers, triblock copolymers; polyethylene glycol and polypropylene glycol block copolymers, poloxamers, polysorbates, alkyl polysaccharides (such as alkyl polyglycosides and mixtures thereof), amine ethoxylates, sorbitan fatty acid esters, glycols and glycerol. Esters, glucosidyl alkyl ethers, sodium tallow, polyoxyethylene glycol, sorbitan alkyl esters, sorbitan derivatives, fatty acid esters of sorbitan (Span) and their ethoxylated derivatives (Tween), sucrose esters of fatty acids, cetostearyl alcohol , Cetyl Alcohol, Cocamide Diethanolamine (DEA), Cocamide Monoethanolamine (MEA), Decyl Glucoside, Decyl Polyglucose, Glycerol Monostearate, Lauryl Glucoside, Maltoside, Monolaurin, Narrow Range Ethoxylates, Nonidet P-40, Nonoxynol -9, nonoxynol, octaethylene glycol monododecyl ether, N-octyl β-D-thioglucopyranoside, octyl glucoside, oleyl alcohol, PEG-10 sunflower glycerides, pentaethylene glycol monododecyl ether, polidocanol, poloxamer, poloxamer 407, polyethoxy Crude tallow amine, polyglycerol polyricinoleate, polysorbate, polysorbate 20, polysorbate 80, sorbitan, sorbitan monolaurate, sorbitan monostearate, sorbitan tristearate, stearyl alcohol, surfactin, glyceryl laurate, lauryl glucoside, nonylphenol polyethoxy Ethanol, nonylphenol polyglycol ethers, castor oil ethoxylates, polyglycol ethers, polyadducts of ethylene oxide and propylene oxide, block copolymers of polyalkylene glycol ethers and hydroxystearic acid, tributylphenoxypolyethoxyethanol, octylphenoxypolyethoxyethanol, ethoxy - propoxylated tristyryl, ethoxylated alcohol, polyoxyethylene sorbitan, fatty acid polyglyceride, fatty acid alcohol polyglycol ether, acetylene glycol, acetylene alcohol, oxyalkylene block polymer, polyoxyethylene alkyl ether, polyoxyethylene alkylaryl ether, poly Oxyethylene styryl aryl ether, polyoxyethylene glycol alkyl ether, polyethylene glycol, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, alcohol ethoxylate-C6 to C16/18 (linear and branched ) alcohols, alcohol alkoxylates - various hydrophobicities and EO/PO contents and ratios, fatty acid esters - monoesters and diesters; lauric, stearic and oleic; glycerol esters - with and without EO laurin, stearin (from cocoa and tall oil), ethoxylated glycerin, sorbitan esters - with and without EO; laurin, stearin, and olein based; mono and trimester, castor oil ethoxylates - 5-200 mol EO; non-hydrogenated and hydrogenated block polymers, amine oxide-ethoxylated and non-ethoxylated; Polyoxypropylene fatty acid esters; including but not limited to one or more of their salts or derivatives.

Amphoteric or zwitterionic surfactants include betaine, coco and laurylamidopropylbetaine, cocoalkyldimethylamine oxide, alkyldimethylbetaine; C8-C18 alkyldipropionate-sodium lauriminodipropionate, coco Amidopropyl hydroxylsulfobetaine, imidazoline, phospholipids phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelin, lauryldimethylamine oxide, alkyl amphoteric acetates and proprionates, alkyl amphoteric (di)acetates, and diproprionates , lecithin and fatty acid amides of ethanolamine; or salts, derivatives thereof, but are not limited thereto.

Surfactants commercially available under their trademarks include Atlas G5000, TERMUL 5429, TERMUL 2510, ECOTERIC®, EULSOGEN® 118, Genapol® X, Genapol® OX- 080, Genapol® C 100, Emulsogen® EL 200, Arlacel P135, Hypermer 8261, Hypermer B239, Hypermer B261, Hypermer B246sf, Solutol HS 15, Promulgen™ D, Soprophor 7961P, Soprophor TSP/461 , Soprophor TSP/724, Croduret 40, Etocas 200, Etocas 29, Rokacet R26, Cetomacrogol 1000, CHEMONIC OE-20, Triton N-101, Triton X-100, Tween 20, 40, 60, 65, 80 , Span 20, 40, 60, 80, 83, 85, 120, Brij®, Atlox 4912, Atlas G5000, TERMUL 3512, TERMUL 3015, TERMUL 5429, TERMUL 2510, ECOTERIC®, ECOTERIC® T85, ECOTERIC ® T20, TERIC 12A4, EULSOGEN® 118, Genapol® X, Genapol® OX-080, Genapol® C 100, Emulsogen® EL 200, Arlacel P135 , Hypermer 8261, Hypermer B239, Hypermer B261, Hypermer B246sf, Solutol HS 15, Promulgen™ D, Soprophor 7961P, Soprophor TSP/461, Soprophor TSP/724, Cro duret 40, Etocas 200, Etocas 29, Rokacet R26, CHEMONIC OE -20, Triton™ N-101, IGEPAL CA-630, and Isoceteth-20.
However, those skilled in the art will recognize that other conventional and known surfactants can be utilized without departing from the scope of the present invention. Surfactants are manufactured commercially and available through various companies.

According to one embodiment, the surfactant is present in an amount of 0.1% to 60% w/w of the total composition. According to one embodiment, the surfactant is present in an amount of 0.1% to 40% w/w of the total composition. According to one embodiment, the surfactant is present in an amount of 0.1% to 30% w/w of the total composition. According to a further embodiment, the surfactant is present in an amount of 0.1% to 20% w/w of the total composition. According to one embodiment, the surfactant is present in an amount of 0.1% to 10% w/w of the total composition.

According to one embodiment, the water-miscible solvent used in the agricultural composition comprises a water-miscible solvent. Water-miscible solvents include 1,4-dioxane, ethylene glycol, N-methyl-2-pyrrolidone, 1,3-propanediol, 1,5-pentanediol, propylene glycol, triethylene glycol, 1,2-butane Examples include, but are not limited to, diols, 1,3-butanediol, 1,4-butanediol, dimethylformamide, dimethoxyethane, dimethyloctanamide, dimethyldecanamide. However, those skilled in the art will recognize that other water-miscible solvents can be utilized without departing from the scope of the invention.

According to one embodiment, the solvent is present in an amount from 0.1% to 95% w/w of the total composition. According to one embodiment, the solvent is present in an amount of 0.1% to 60% w/w of the total composition. According to one embodiment, the solvent is present in an amount of 0.1% to 40% w/w of the total composition. According to one embodiment, the solvent is present in an amount of 0.1% to 30% w/w of the total composition.

According to one embodiment, disintegrants used in agricultural compositions include inorganic water-soluble salts (e.g. sodium chloride, nitrates); water-soluble organic compounds (agar, hydroxypropyl starch, carboxymethyl starch ether, tragacanth , gelatin, casein, microcrystalline cellulose, crosslinked sodium carboxymethylcellulose, carboxymethylcellulose, calcium carboxymethylcellulose, sodium tripolyphosphate, sodium hexametaphosphate, metal stearate, cellulose powder, dextrin, methacrylate copolymer, Polyplasdone Trademarks) XL-10 (crosslinked polyvinylpyrrolidone), poly(vinylpyrrolidone), sulfonated styrene-isobutylene-maleic anhydride copolymer, salt of polyacrylate of methacrylate, starch-polyacrylonitrile graft copolymer, etc.), Sodium or potassium bicarbonate/sodium or potassium carbonate, or mixtures thereof with or salts with acids (such as citric acid and fumaric acid) or one or more of their salts, derivatives but not limited to these. However, those skilled in the art will recognize that different disintegrants can be utilized without departing from the scope of the invention. Disintegrants are manufactured commercially and available through various companies.

According to one embodiment, the disintegrant is present in an amount of 0.1% to 50% w/w of the composition. According to one embodiment, the disintegrant is present in an amount of 0.1% to 30% w/w of the composition. According to one embodiment, the disintegrant is present in an amount of 0.1% to 20% w/w of the composition. According to one embodiment, the disintegrant is present in an amount of 0.1% to 10% w/w of the composition.

According to one embodiment, the hydrophobic agents include one or more of modified starches, hydrophobically modified silicates, bentonites, attapulgite, talc, metal stearates, and fluorinated silanes. but not limited to these. However, those skilled in the art will recognize that different hydrophobic agents can be utilized without departing from the scope of the invention. According to one embodiment, the hydrophobic agent is present at a concentration of 0.1% to 50% w/w of the total composition.

According to one embodiment, binders or binders used in the agricultural composition include proteins, lipoproteins, lipids, glycolipids, glycoproteins, carbohydrates (monosaccharides, disaccharides, oligosaccharides and polysaccharides). etc.), complex organic substances, synthetic organic polymers, or derivatives and combinations thereof. However, those skilled in the art will recognize that different binding agents can be utilized without departing from the scope of the invention. Binders are manufactured commercially and available through various companies.

According to a further embodiment, the binder is present in an amount of 0.1% to 30% w/w of the composition. According to a further embodiment, the binder is present in an amount of 0.1% to 20% w/w of the composition. According to a further embodiment, the binder is present in an amount of 0.1% to 10% w/w of the composition.

According to one embodiment, carriers used in agricultural compositions include, but are not limited to, one or more of a solid carrier or filler or diluent substance. According to another embodiment, the carrier includes mineral carriers, botanical carriers, synthetic carriers, water-soluble carriers. However, those skilled in the art will recognize that different carriers can be utilized without departing from the scope of the invention. Carriers are manufactured commercially and available through a variety of companies.

Solid carriers include clay (pottery clay, acid clay, etc.), kaolin (kaolinite, dickite, nacrite, halloysite, etc.), serpentine (chrysotile, lizardite, antigorite, amesite, etc.), synthetic silica and diatomaceous silica. , montmorillonite minerals (such as sodium montmorillonite), smectites (such as saponite, hectorite, sauconite, and hyderite), mica (such as pyrophyllite, talc, agarmatolite, muscovite, phengite, sericite, and illite), silica (such as cristobalite), and quartz (such as attapulgite and sepiolite); vermiculite, laponite, pumice, bauxite, hydrated alumina, perlite, sodium bicarbonate, volclay, vermiculite, limestone, natural and synthetic silicates, activated carbon. , silica, wet silica, fumed silica, calcined products of wet silica, surface-modified silica, mica, zeolites, diatomaceous earth, derivatives thereof; chalk (Omya®), Fuller's earth, loess, sulfite, white carbon , slaked lime, synthetic silicic acid, starch, modified starch (Pineflow, available from Matsutani Chemical Industry Co., Ltd.), cellulose, vegetable carriers (cellulose, rice husks, wheat flour, wood flour, starch, rice bran, bran and soy flour, tobacco powder, vegetable powder, etc.), polyethylene, polypropylene, poly(vinylidene chloride), methylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium carboxymethylcellulose, propylene glycol alginate, polyvinylpyrrolidone, carboxyvinyl polymer, sodium caseinate, sucrose , mirabilite, potassium pyrophosphate, sodium tripolyphosphate, maleic acid, fumaric acid, and malic acid, or derivatives or mixtures thereof. Commercially available silicates are Aerosil brand, Sipernat brand as Sipernat® 50S, and CALFLO E, and Kaolin 1777. However, those skilled in the art will recognize that different solid supports can be utilized without departing from the scope of the invention. Solid supports are manufactured commercially and available through a variety of companies.

According to one embodiment, the carrier is present in an amount of 0.1% to 98% w/w of the composition. According to a further embodiment, the carrier is present in an amount of 0.1% to 80% w/w of the composition. According to a further embodiment, the carrier is present in an amount of 0.1% to 60% w/w of the composition. According to a further embodiment, the carrier is present in an amount of 0.1% to 40% w/w of the composition. According to a further embodiment, the carrier is present in an amount of 0.1% to 20% w/w of the composition.

According to one embodiment, defoamers or suds suppressors used in agricultural compositions include silica, siloxanes, silicone dioxides, polydimethylsiloxanes, polyalkyl acrylates, ethylene oxide/propylene oxide copolymers, polyethylene. Examples include, but are not limited to, one or more of glycols, silicone oils, and magnesium stearate, or derivatives thereof. Preferred defoamers include silicone emulsions (such as Silicone® SRE, Wacker, or Rhodorsil® from Rhodia), long chain alcohols, fatty acids, fluoro-organic compounds. However, those skilled in the art will recognize that other conventionally known antifoam agents can be utilized without departing from the scope of the present invention. Defoamers are manufactured commercially and available through various companies. According to one embodiment, the antifoam agent is present in an amount of 0.01% to 20% w/w of the total composition.

According to one embodiment, pH adjusting or buffering or neutralizing agents used in agricultural compositions include both organic or inorganic type acids and bases, and mixtures thereof. According to further embodiments, pH adjusting or buffering or neutralizing agents include, but are not limited to, one or more of organic and inorganic acids and alkali metal compounds, or salts, derivatives thereof. not. According to one embodiment, the organic acids include citric, malic, adipic, fumaric, maleic, succinic, and tartaric acids, or salts, derivatives thereof; Including but not limited to one or more of the base salts, or tribasic salts, or derivatives thereof. Examples of alkali metal compounds include alkali metal hydroxides (sodium hydroxide, potassium hydroxide, etc.), alkali metal carbonates (sodium carbonate, etc.), alkali metal hydrogencarbonates (sodium hydrogencarbonate, etc.), and alkali metal Including, but not limited to, one or more of phosphate salts (such as sodium phosphate), as well as mixtures thereof. According to one embodiment, salts of inorganic acids include alkali metal salts (lithium chloride, sodium chloride, potassium chloride, lithium nitrate, sodium nitrate, potassium nitrate, lithium sulfate, sodium sulfate, potassium sulfate, sodium monohydrogen phosphate, potassium monohydrogen phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, and the like). Mixtures can also be used to produce pH adjusting or buffering or neutralizing agents. However, those skilled in the art will recognize that other conventionally known pH adjusting or buffering or neutralizing agents can be utilized without departing from the scope of the present invention. pH adjusting or buffering or neutralizing agents are manufactured commercially and available through various companies.

According to one embodiment, the pH adjusting or buffering substance is present in an amount of 0.01% to 20% w/w of the total composition. According to one embodiment, the pH adjusting or buffering substance is present in an amount of 0.01% to 10% w/w of the total composition. According to one embodiment, the pH adjusting or buffering substance is present in an amount of 0.01% to 5% w/w of the total composition. According to one embodiment, the pH adjusting or buffering substance is present in an amount of 0.01% to 1% w/w of the total composition.

According to one embodiment, the spreading agents used in the agricultural composition include cellulose powder, dextrins, modified starches, crosslinked poly(vinylpyrrolidone), copolymers of maleic acid and styrenic compounds, (Meth)acrylic acid copolymers, polymer half-esters composed of dicarboxylic acid anhydrides and polyhydric alcohols, water-soluble salts of polystyrene sulfonic acid, fatty acids, latexes, fatty alcohols, vegetable oils (such as cottonseed) or inorganic oils, petroleum distillation compounds, modified trisiloxanes, polyglycols, polyethers, clathrates, or salts or derivatives thereof. However, those skilled in the art will recognize that other conventionally known spreading agents can be utilized without departing from the scope of the present invention. Spreading agents are manufactured commercially and available through various companies.

According to one embodiment, the spreading agent is present in an amount of 0.01% to 20% w/w of the total composition. According to one embodiment, the spreading agent is present in an amount of 0.01% to 5% w/w of the total composition.

According to one embodiment, the sticking agents used in the agricultural composition include paraffins, polyamide resins, polyacrylates, polyoxyethylenes, waxes, polyvinyl alkyl ethers, alkylphenol-formalin condensates, fatty acids, latexes. , fatty alcohols, vegetable oils (such as cottonseed) or inorganic oils, petroleum distillates, modified trisiloxanes, polyglycols, polyethers, clathrates, synthetic resin emulsions, or salts or derivatives thereof. Including but not limited to one or more. However, those skilled in the art will recognize that other conventionally known adhesives can be utilized without departing from the scope of the present invention. Sticking agents are manufactured commercially and available through various companies.

According to one embodiment, the sticking agent may be present in an amount of 0.01% to 30% w/w of the total composition. According to one embodiment, the sticking agent is present in an amount of 0.01% to 15% w/w of the total composition.

According to one embodiment, stabilizing substances used in agricultural compositions include peroxide compounds (such as hydrogen peroxide and organic peroxides), alkyl nitrites (such as ethyl nitrite) and glyoxylic acid. Including, but not limited to, one or more of alkyls (such as ethyl glyoxylate), zeolites, antioxidants (such as phenolic compounds), phosphate compounds, and the like. However, those skilled in the art will recognize that other conventionally known stabilizing agents can be utilized without departing from the scope of the present invention. Stabilizing agents are manufactured commercially and available through various companies.

According to one embodiment, the stabilizing substance is present in an amount of 0.01% to 30% w/w of the total composition. According to one embodiment, the stabilizing agent is present in an amount of 0.01% to 20% w/w of the total composition. According to one embodiment, the stabilizing agent is present in an amount of 0.01% to 10% w/w of the total composition.

According to one embodiment, the preservatives used in the agricultural composition include one or more of fungicides, antifungals, biocides, antimicrobials, and antioxidants. but not limited to these. Non-limiting examples of preservatives include parabens, their esters and salts, propionic acid and its salts, 2,4-hexadienoic acid (sorbic acid) and its salts, formaldehyde and paraformaldehyde, 2-hydroxybiphenyl ether and its salts, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, dehydraacetic acid, formic acid, 1,6-bis(4-amidino-2-bromophenoxy)-n-hexane and its salts, 5- amino-1,3-bis(2-ethylhexyl)-5-methylhexahydropyrimidine, 5-bromo-5-nitro-1,3-dioxane, 2-bromo-2-nitropropane-1,3-diol, 2 ,4-dichlorobenzyl alcohol, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)urea, 4-chloro-m-cresol, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 4-chloro-3,5-dimethylphenol, 1,1′-methylene-bis(3-(1-hydroxymethyl-2,4-di-oximidazolidin-5-yl)urea)poly(hexa methylenediguanide) hydrochloride, 2-phenoxyethanol, hexamethylenetetramine, 1-(3-chloroallyl)-3,5,7-triaza-1-azonia-adamantane chloride, 1(4-chlorophenoxy)-1-( 1H-imidazol-1-yl)-3,3-dimethyl-2-butanone, 1,3-bis(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidinedione, benzyl alcohol, octopirox, 1,2-dibromo-2,4-dicyanobutane, 2,2′-methylenebis(6-bromo-4-chlorophenol), bromochlorophene, dichlorophene, 2-benzyl-4-chlorophenol, 2-chloroacetamide , chlorhexidine, chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, 1-phenoxypropan-2-ol, N-alkyl (C12-C22) trimethylammonium bromide and chloride, 4,4-dimethyl-1,3-oxazolidine, N- Hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'-hydroxymethylurea, 1,6-bis(4-amidinophenoxy)-n Hexane and its salts, glutaraldehyde, 5-ethyl-1-aza-3,7-dioxabicyclo(3.3.0)octane, 3-(4-chlorophenoxy)propane-1,2-diol, Hyamine, Alkyl (C8-C18) dimethylbenzylammonium chloride, Alkyl (C8-C18) dimethylbenzylammonium bromide, Alkyl (C8-C18) dimethylbenzylammonium saccharin, Benzylhemiformal, 3-iodo-2-propynylbutylcarbamate, Hydroxymethyl sodium aminoacetate, cetyltrimethylammonium bromide, cetylpyridium chloride, and derivatives of 2H isothiazol-3-one (so-called isothiazolone derivatives) alkylisothiazolones, etc. (for example 2-methyl-2H-isothiazol-3-one, MIT; chloro-2-methyl-2H-isothiazol-3-one, CIT), benzisothiazolones (eg 1,2-benzisothiazol-3(2H)-one, BIT, ICI to Proxel® type) ) or 2-methyl-4,5-trimethylene-2H-isothiazol-3-one (MTIT), C1-C4-alkyl para-hydroxybenzoate, dichlorophene, Proxel® from ICI or Thor Acticide® RS from Chemie and Kathon® MK from Rohm & Haas, Bacto-100, Thimerosal, Sodium Propionate, Sodium Benzoate, Propylparaben, Sodium Propylparaben, Potassium Sorbate, Potassium Benzoate , phenylmercuric nitrate, phenylethyl alcohol, sodium, ethylparaben, methylparaben, butylparaben, bezyla alcohol, benzothonium chloride, cetylpyridium chloride, benzalkonium chloride, 1,2-benzothiazole-3 -one, Preventol® (Lanxess®), butylhydroxytoluene, potassium sorbate, iodine-containing organic compounds (3-bromo-2,3-diiodo-2-propenylethyl carbonate, 3-iodo-2 -propynyl butyl carbamate, 2,3,3-triiodoallyl alcohol, and parachlorophenyl-3-iodopropargyl formal, etc.); benzimidazole compounds and benzothiazole compounds (2-(4-thiazolyl)benzimidazole and 2-thiocyano methylthiobenzo-thiazole, etc.); triazole compounds (1-(2-(2',4'-dichlorophenyl)-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazole, 1-(2 -(2′,4′-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl)-1H-1,2,4-triazole and α-(2-(4-chlorophenyl)ethyl)- α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol, etc.); and naturally occurring compounds (4-isopropyltropolone (hinokitiol) and boraxor salts, etc.), or one or more of their derivatives. Antioxidants include imidazole and imidazole derivatives (eg urocanic acid), 4,4′-thiobis-6-t-butyl-3-methylphenol, 2,6-di-t-butyl-p-cresol (BHT) , pentaerythrityl tetrakis[3-(3,5,-di-t-butyl-4-hydroxyphenyl)]propionate; amine antioxidants (N,N'-di-2-naphthyl-P-paraphenylenediamine, etc. ); hydroquinoline antioxidants (2,5-di(t-amyl)hydroquinoline, etc.); phosphorus-containing antioxidants (triphenyl phosphate, etc.), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene ), and derivatives thereof, lipoic acid and its derivatives (eg dihydrolipoic acid), aurothioglucose, propylthiouracil, and further thio compounds (eg thioglycerol, thiosorbitol, thioglycolic acid, thioredoxin, N-acetyl, methyl , ethyl, propyl, amyl, butyl, lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl, and their glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid , and derivatives thereof (esters, ethers, lipids, nucleotides and nucleosides and salts), and very low tolerable doses (eg, pmol/kg to pmol/kg) of sulfoximine compounds (eg, buthionine sulfoximine, homocysteine sulfoximine, amine, buthionine sulfone, penta-, hexa-, heptathionine sulfoximine), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, gallates (e.g. propyl gallate, octyl gallate, and dodecyl gallate), unsaturated fatty acids and derivatives, hydroquinone and its derivatives (e.g. arbutin), ubiquinone and ubiquinol and their derivatives, ascorbyl palmitate, ascorbyl stearate, ascorbyl dipalmitate, ascorbyl acetate, Mg ascorbyl phosphate , disodium ascorbyl phosphate and disodium ascorbyl sulfate, potassium ascorbyl tocopheryl phosphate, isoascorbic acid and their derivatives, coniferyl benzoate of benzoin resins, rutin, rutinic acid and their derivatives, rutinyl disodium disulfate, dibutylhydroxytoluene, 4,4-thiobis-6-tert-butyl-3-methylphenol, butylhydroxyanisole, p-octylphenol, mono-(di- or tri-)methylbenzylphenol, 2,6 -tert-butyl-4-methylphenol, pentaerythritol-tetrakis 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate, butylhydroxyanisole, nordihydroguaiacic acid, nordihydro one of guaiaretic acid, trihydroxybutyrophenone, uric acid and derivatives thereof, mannose and its derivatives, selenium and selenium derivatives (eg selenomethionine), stilbene and stilbene derivatives (eg stilbene oxide, trans-stilbene oxide) or multiple, including but not limited to. However, those skilled in the art will recognize that other conventionally known preservatives can be utilized without departing from the scope of the present invention. Antiseptics are manufactured commercially and available through a variety of companies.

According to one embodiment the antiseptic or bactericidal or antifungal or biocide or antimicrobial or antioxidant is present in an amount of 0.01% to 20% w/w of the total composition. According to a further embodiment the antiseptic or bactericidal or antifungal or biocide or antimicrobial or antioxidant is present in an amount of 0.01% to 10% w/w of the total composition. According to a further embodiment the antiseptic or bactericidal or antifungal or biocide or antimicrobial or antioxidant is present in an amount of 0.01% to 5% w/w of the total composition. According to a further embodiment the antiseptic or bactericidal or antifungal or biocide or antimicrobial or antioxidant is present in an amount of 0.01% to 1% w/w of the total composition.

According to one embodiment, the structurant used in the agricultural composition includes among thickeners, viscosity modifiers, tackifiers, suspension aids, rheology modifiers or anti-settling agents. including but not limited to one or more of Structuring agents prevent sedimentation of active ingredient particles after long-term storage.

According to one embodiment, the structuring agent used in the aqueous suspension composition includes one or more polymers (polyacrylic acid and polyacrylamide, polysaccharides, hydrophobically modified cellulose derivatives, cellulose derivatives carboxyvinyl or polyvinylpyrrolidone, polyethylene, polyethylene oxide, polyvinyl alcohol, and derivatives thereof, etc.); gum, tragacanth gum, rhamzan gum, locust bean gum, carrageenan, welan gum, veegum, etc.), gelatin, dextrin, collagen; polyacrylic acid and their sodium salts; polyglycol ethers of fatty alcohols and polyethylene oxide or polypropylene oxide condensation products; mixtures thereof, and those containing ethoxylated alkylphenols (also indicated in the art as alkylarylpolyether alcohols); ethoxylated fatty alcohols (or alkylpolyether alcohols); ethoxylated fatty acids (or polyoxyethylene fatty acid esters) ); ethoxylated sorbitol anhydride esters (or polyethylene sorbitan fatty acid esters), nonionic long-chain amines and cyclic amine oxides in basic solution; long-chain tertiary phosphine oxides; and long-chain dialkyl sulfoxides, fumed silica, Mixtures of fumed silica and fumed aluminum oxide, swellable polymers, polyamides or derivatives thereof; polyols (such as glycerin), poly(vinyl acetate), sodium polyacrylate, poly(ethylene glycol), phospholipids (e.g. cephalin and similar stachyose, fructo-oligosaccharides, amylose, pectin, alginates, hydrocolloids, and mixtures thereof. Cellulose (hemicellulose, carboxymethylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylethylcellulose, hydroxylethylpropylcellulose, methylhydroxyethylcellulose, methylcellulose, etc.); starch (starch acetate, starch hydroxyethyl ether, ionic starch, long-chain alkyl starch, dextrin, maltodextrin, corn starch, amine starch, phosphate starch, dialdehyde starch, etc.); vegetable starches (corn starch and potato starch, etc.); other carbohydrates (pectin, dextrin, amylopectin, xylan, glycogen, agar, gluten, alginic acid, phycochoroid, etc.), or derivatives thereof. However, those skilled in the art will recognize that other conventionally known structuring agents can be utilized without departing from the scope of the present invention.

Preferred structurants include one or more of xanthan gum, guar gum, aluminum silicate, methylcellulose and its derivatives, polysaccharides, alkaline earth metal silicates, and polyvinyl alcohol. Structuring agents are manufactured commercially and available through various companies.

According to one embodiment, the structurant is present in an amount of 0.01% to 5% w/w of the composition. According to one embodiment, the structurant is present in an amount of 0.01% to 4% w/w of the composition. According to one embodiment, the structurant is present in an amount of 0.01% to 3% w/w of the composition. According to one embodiment, the structurant is present in an amount of 0.01% to 2% w/w of the composition. According to one embodiment, the structurant is present in an amount of 0.01% to 1% w/w of the composition. According to one embodiment, the structurant is present in an amount of 0.01% to 0.1% w/w of the composition.

According to one embodiment, the anti-caking or anti-settling or suspending agents used include polysaccharides (starch, mannose, galactose, etc.), cellulose derivatives (sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxy gums (sagar, carrageenan, alginate, arabic, tragacanth, karaya, gati, guar, etc.), dextrans, starches (pregelatinized starches and modified starch), poly(vinylpyrrolidone), fumed silica (white carbon), ester gum, petroleum resin, Foammaster® Soap L sodium stearate, Brij® 700, polyoxyethylene (100 ) stearyl ether, Aerosol® OT-B sodium dioctyl sulfosuccinate, Silwet® L-77 silicone-polyether copolymer, sodium acetate, sodium metasilicate, sodium alkyl sulfosuccinate, salts or derivatives thereof. but not limited to these. However, those skilled in the art will recognize that different anti-caking agents can be utilized without departing from the scope of the present invention. Anti-caking agents or anti-settling agents or suspending agents or suspending aids are manufactured commercially and available through various companies.

According to one embodiment the anti-caking agent or anti-settling agent or suspending agent or suspending aid is present in an amount of 0.01% to 20% w/w of the total composition. According to one embodiment the anti-caking agent or anti-settling agent or suspending agent or suspending aid is present in an amount of 0.01% to 15% w/w of the total composition. According to one embodiment, the anti-caking or anti-settling agent or suspending agent or suspending aid is present in an amount of 0.01% to 10% w/w of the total composition.

According to one embodiment, antifreeze agents or freezing point depressants used in the aqueous suspension compositions include polyhydric alcohols (ethylene glycol, diethylene glycol, dipropylene glycol, propylene glycol, etc.), butyrolactone, N,N - dimethyl-formamide, glycerol, monohydric or polyhydric alcohols, glycol ethers, glycol ethers, glycol monoethers (such as the methyl, ethyl, propyl and butyl ethers of ethylene glycol, diethylene glycol, propylene glycol and dipropylene glycol) glycol di Ethers (such as the methyl and ethyl diethers of ethylene glycol, diethylene glycol and dipropylene glycol), or urea, glycerol, isopropanol, propylene glycol monomethyl ether, di- or tripropylene glycol monomethyl ether, or cyclohexanol, carbohydrates (glucose, mannose, fructose, galactose, sucrose, lactose, maltose, xylose, arabinose, sorbitol, mannitol, trehalose, raffinose, etc.) or derivatives thereof. However, those skilled in the art will recognize that different cryoprotectants can be utilized without departing from the scope of the invention. Cryoprotectants are manufactured commercially and available through various companies. According to one embodiment, the cryoprotectant is present in an amount of 0.1% to 20% w/w of the total composition.

According to one embodiment, osmotic agents used in the composition include alcohols, glycols, glycol ethers, esters, amines, alkanolamines, amine oxides, quaternary ammonium compounds, triglycerides, fatty acid esters, fatty acid ethers, N-methylpyrrolidone, dimethylformamide, dimethylacetamide or dimethylsulfoxide, polyoxyethylene trimethylolpropane monooleate, polyoxyethylene trimethylolpropane dioleate, polyoxyethylene trimethylolpropane trioleate, polyoxyethylene sorbitan monooleate , polyoxyethylene sorbitol hexaoleate. However, those skilled in the art will recognize that different permeants can be utilized without departing from the scope of the present invention. Osmotic agents are manufactured commercially and available through a variety of companies. According to one embodiment, the penetrant is present in an amount of 0.01% to 10% w/w of the total composition.

According to one embodiment, the UV-absorbing material is 2-(2′-hydroxy-5′-methylphenyl)benzotriazole, 2-ethoxy-2′-ethyloxazalinic acid bisanilide, dimethyl-1-succinate ( 2-hydroxyethyl)-4-hydroxy-2,2,6,6-tetramethylpiperidine polycondensate, benzotriazole compound (2-(2'-hydroxy-5'-methylphenyl)benzotriazole and 2-(2 '-hydroxy-4'-n-octoxyphenyl)benzotriazole, etc.); benzophenone compounds (2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-n-octoxybenzophenone, etc.); salicylate compounds (phenyl salicylate and pt-butylphenyl salicylate, etc.); 2-ethylhexyl 2-cyano-3,3-diphenyl acrylate, 2-ethoxy-2′-ethyl bisanilide oxalate, and dimethyl-1-(2-hydroxyethyl succinate) )-4-hydroxy-2,2,6,6-tetramethylpiperidine polycondensates, or derivatives or the like, but are not limited thereto. However, those skilled in the art will recognize that different UV absorbing materials can be utilized without departing from the scope of the present invention. Such UV absorbing materials are manufactured commercially and available through various companies.

According to one embodiment, UV scattering agents may be used including but not limited to titanium dioxide or the like. However, those skilled in the art will recognize that different UV scattering agents or mixtures thereof can be utilized without departing from the scope of the present invention. Such UV scattering agents are manufactured commercially and available through various companies.

According to one embodiment, the moisturizing substance is one or more of polyoxyethylene/polyoxypropylene copolymers, especially block copolymers (such as the Synperonic PE series of copolymers available from Uniqema), or salts, derivatives thereof are selected from, but not limited to: Other moisturizing substances include propylene glycol, monoethylene glycol, hexylene glycol, butylene glycol, ethylene glycol, diethylene glycol, poly(ethylene glycol), poly(propylene glycol), glycerol, and the like; polyhydric alcohols or their It is a derivative. Other moisturizing substances include aloe vera gel, alpha hydroxyl acid (such as lactic acid), albumin, glyceryl triacetate, honey, calcium chloride, and the like. The nonionic surfactants mentioned above also act as humectants. However, those skilled in the art will recognize that other conventional and known moisturizing substances can be utilized without departing from the scope of the present invention. Moisturizing substances are manufactured commercially and available through various companies.

According to one embodiment, the moisturizing substance is present in the range of 0.1% to 30% w/w of the total composition. According to one embodiment, the moisturizing substance is present in the range of 0.1% to 20% w/w of the total composition. According to one embodiment, the moisturizing substance is present in the range of 0.1% to 10% w/w of the total composition.

The pest control compositions of the present invention have dispersibility, suspendability, wettability, viscosity, enhanced injectability and improved physical properties, provide ease of handling, and reduce product loss during packaging. It has been surprisingly found to reduce material loss during handling and field application.

Wettability is the condition or state of being wettable and can be defined as the degree to which a solid is wetted by a liquid and is measured by the force of adhesion between the solid and liquid phases. The wettability of a granular composition is measured using standard CIPAC test MT-53, which describes a procedure for determining the time to complete wetting of wet formulations. A weighed amount of the granular composition was dropped from a defined height onto the water in the beaker to determine the time for complete wetting. According to another embodiment, the pest control composition in the form of water dispersible granules or spheronized granules has a wettability of less than 2 minutes. According to another embodiment, the pest control composition has a wettability of less than 1 minute. According to another embodiment, the pest control composition has a wettability of less than 30 seconds. According to another embodiment, the pest control composition has a wettability of less than 15 seconds.

The spheronized granule composition is formulated in such a manner that the granules are imparted with sufficient hardness to prevent crumbling during storage and shipping. The hardness exhibited by the granules can be estimated by hardness testers such as those provided by Shimadzu, Brinell hardness (AKB-3000 model), Mecmesin, Agilent, Vinsyst, Ametek, and Rockwell.

According to one embodiment, the hardness exhibited by the granules is less than 100 Newtons. According to one embodiment, the hardness exhibited by the granules is less than 90 Newtons. According to one embodiment, the hardness exhibited by the granules is less than 80 Newtons. According to one embodiment, the hardness exhibited by the granules is less than 70 Newtons. According to one embodiment, the hardness exhibited by the granules is less than 60 Newtons. According to one embodiment, the hardness exhibited by the granules is less than 50 Newtons.

According to one embodiment, the water-dispersible granular composition of the invention has little hardness.

According to one embodiment, the pest control composition in the form of water dispersible granules or liquid suspension passes the wet sieve retention test. The test is used as a dispersion in water to determine the amount of non-dispersible material in the applied formulation. Wet sieve retention values for agrochemical compositions in the form of liquid suspensions and granules are determined by using standard CIPAC test MT-185, which describes a procedure for determining the amount of material retained on sieves. be done. A sample of the formulation is dispersed in water and the suspension formed is transferred to a sieve and washed. The amount of material retained on the sieve is determined by drying and weighing.

According to one embodiment, the pest control composition in the form of water dispersible granules or liquid suspension has a wet sieve retention value on a 75 micron sieve of less than 0.5%. According to one embodiment, the pest control composition has a wet sieve retention value on a 75 micron sieve of less than 0.2%. According to one embodiment, the pest control composition has a wet sieve retention value on a 75 micron sieve of less than 0.1%. A pest control composition with a wet sieve retention value of less than 0.5% has been shown to aid in easy application of the formulation to prevent nozzle or filter device clogging.

According to one embodiment, the pest control composition in the form of a liquid suspension does not settle or pile up upon storage and is readily pourable. This property can be measured in terms of the viscosity of a liquid, which is a measure of resistance to gradual deformation by shear or tensile stress.

According to one embodiment, the viscosity of the liquid composition is determined according to CIPAC MT-192. Samples are transferred to a standard measurement system. Measurements are performed under different shear conditions to determine the apparent viscosity. The temperature of the liquid is kept constant during the test.

According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 3000 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 2500 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 2000 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 1500 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 1200 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 500 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of less than about 500 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 400 cps at 25°C. According to one embodiment, the pest control composition has a viscosity of from about 10 cps to about 300 cps at 25°C.

According to one embodiment, the liquid suspension compositions of the invention are readily injectable. Injectability is a measure of percent residue.

According to one embodiment, the injectability of the pesticidal composition is determined according to CIPAC MT-148 by allowing the liquid suspension to stand for 24 hours and determining the amount remaining in the container after a standardized injection procedure. .1. Rinse the container, then determine the amount remaining and calculate the maximum residue in percent. According to further embodiments, the injectability of the pest control composition is less than 5% residual. According to a further embodiment, the injectability of the pest control composition is preferably less than 2.5% residual. According to a further embodiment, the injectability of the pest control composition is more preferably less than 2.0% residual.

The dispersibility of pest control compositions in the form of water-dispersible granules or spheroidized granules and liquid suspensions is a measure of percent dispersion. Dispersibility is calculated by the minimum percent variance. Dispersibility is defined as the ability of granules to disperse upon addition to a liquid (such as water or solvent). The dispersibility of the granule composition of the present application was determined according to the standard CIPAC test, MT174. A known amount of granular composition was added to a defined volume of water and mixed by stirring to form a suspension. After standing for a short period of time, the top nine tenths were poured off and the remaining tenths were dried and determined gravimetrically. The method is effectively a shortened test of suspendability and is suitable for establishing the ease with which a granular composition is uniformly dispersed in water.

According to one embodiment, the pest control composition has a dispersibility of at least 30%. According to one embodiment, the pest control composition has a dispersibility of at least 40%. According to one embodiment, the pest control composition has a dispersibility of at least 50%. According to one embodiment, the pest control composition has a dispersibility of at least 60%. According to one embodiment, the pest control composition has a dispersibility of at least 70%. According to one embodiment, the pest control composition has a dispersibility of at least 80%. According to one embodiment, the pest control composition has a dispersibility of at least 90%. According to one embodiment, the pest control composition has a dispersibility of at least 99%. According to one embodiment, the pest control composition has 100% dispersibility.

According to one embodiment, the pest control composition in the form of water-dispersible granules exhibits almost instantaneous dispersion.

According to one embodiment, the pesticidal composition in the form of spheroidized granules makes the active agent available immediately and also for an extended longer period of time throughout the crop cycle, providing immediate release and sustained release of the active agent. It provides release and ultimately strengthens and protects the crop at each and every stage of the crop cycle.

According to one embodiment, the pest control composition in the form of water-dispersible granules or spheroidized granules, liquid suspension, exhibits good suspendability. Suspendability is defined as the amount of active ingredient after a given time suspended in a column of liquid of specified height, expressed as a percentage of the amount of active ingredient in the original suspension. be done. Water-dispersible granules can be tested for suspendability according to the CIPAC Handbook "MT184 Test for Suspension", by preparing a suspension of known concentration of the composition in CIPAC's reference water, It was placed in a graduated cylinder indicated by temperature and left undisturbed for the specified time. The top 9/10 was drained off, then the remaining 1/10 was assayed chemically, gravimetrically, or by solvent extraction and the suspensibility was calculated.

Suspendability of a liquid suspension is the activity after a given time suspended in a column of liquid of specified height, expressed as a percentage of the amount of active ingredient in the original suspension. amount of ingredients. The suspensibility of the liquid suspension concentrate was determined by preparing 250 ml of the diluted suspension, letting it stand in a graduated cylinder under defined conditions, and removing the top nine tenths. Determined according to MT-161. The remaining tenths are then assayed chemically, gravimetrically, or by solvent extraction and the suspensibility is calculated.

According to one embodiment, the pest control composition has a suspendability of at least 30%. According to one embodiment, the pest control composition has a suspendability of at least 40%. According to one embodiment, the pest control composition has a suspendability of at least 50%. According to one embodiment, the pest control composition has a suspendability of at least 60%. According to one embodiment, the pest control composition has a suspendability of at least 70%. According to one embodiment, the pest control composition has a suspendability of at least 80%. According to one embodiment, the pest control composition has a suspendability of at least 90%. According to one embodiment, the pest control composition has a suspendability of at least 99%. According to one embodiment, the pest control composition has 100% suspendability.

According to one embodiment, the pest control composition in the form of water-dispersible granules or spheroidized granules, liquid suspension, demonstrates excellent stability with respect to suspendability under accelerated storage conditions (ATS). . According to one embodiment, the pest control composition exhibits greater than 90% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 80% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 70% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 60% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 50% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 40% suspendability under ATS. According to one embodiment, the pest control composition exhibits greater than 30% suspendability under ATS.

According to one embodiment, the pest control composition demonstrates greater than 90% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 80% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 70% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 60% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 50% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 40% dispersibility under ATS. According to one embodiment, the pest control composition demonstrates greater than 30% dispersibility under ATS.

According to one embodiment, the pest control composition demonstrates excellent stability to heat, light, temperature, and solidification. The composition does not form a hard cake and exhibits enhanced stability even with extended storage under higher temperatures, which likewise provides excellent field performance. According to further embodiments, the stability exhibited by the pest control composition is at least 3 years. According to further embodiments, the stability exhibited by the pest control composition is at least two years. According to further embodiments, the stability exhibited by the pest control composition is at least one year. According to further embodiments, the stability exhibited by the pesticidal composition is at least 6 months.

According to one embodiment, the present invention provides elemental sulfur present in the range of 40% w/w to 95% w/w of the total composition and 0.1% w/w to 3% w/w of the total composition. at least one antranilic diamide pesticide present in the range of 0./w, in the form of water-dispersible granules or spheroidized granules, liquid suspension, wherein 0. It relates to a process for preparing said composition having particles in the size range of 1 micron to 50 microns.

According to another embodiment, the pesticidal composition in the form of water dispersible granules or spheronized granules is prepared by various techniques (spray drying, fluid bed granulation, dish granulation, pin agglomerator). ), spheronizer, freeze-drying, etc.). Granules can also be extruded through an extruder to obtain extruded granules.

According to one embodiment, the process of preparing the water-dispersible granular composition comprises adding an admixture of elemental sulfur and at least one anthranilic diamide pesticide to at least one agrochemical grade to obtain a slurry or wet mixture. grinding with excipients of The resulting wet mixture is then dried in, for example, a spray dryer or fluid bed dryer, or any suitable granulation equipment, followed by sieving, if required, to remove undersized and oversized granules. Remove to obtain water-dispersible granules of desired size. However, those skilled in the art will recognize that the process or process parameters can be modified or altered or varied to obtain a water-dispersible granular composition without departing from the scope of the present invention.

According to another embodiment, the present invention comprises grinding an admixture of elemental sulfur and at least one anthranilic diamide pesticide with at least one agrochemical excipient to obtain a slurry or wet mixture. It further relates to a process of preparing spheroidized granules comprising: The resulting wet mixture is then dried in, for example, a spray dryer, fluid bed dryer, or any suitable granulation equipment, followed by sieving to remove granules that are too small and too large to obtain granules. . The powder or fine granules are further subjected to agglomeration in an agglomerator to obtain granules with a size of 0.1 mm to 6 mm. Aggregators can include a variety of devices such as disc pelletizers or dish granulators, pin agglomerators, spheronizers, or combinations. Water can also be added to the powder or fine granules to obtain a dough or paste which is then extruded through an extruder to obtain granules of desired size. Granules can also be formed by hot melt extrusion.

The granules obtained from the granulator can also be dried in the open air or air dried to remove residual moisture, if any. However, one of ordinary skill in the art will recognize that modifications or alterations or variations in the process or process parameters may be made without departing from the scope of the present invention.

According to another embodiment, the invention relates to a process of preparing a liquid suspension composition.

According to one embodiment, the present invention is a process for the preparation of a liquid suspension pesticide composition comprising elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable homogenizing the mixture of excipients to obtain a suspension, and wet milling the resulting suspension to provide a composition with a particle size range of 0.1 microns to 50 microns; The above process, comprising

According to one embodiment, the process of preparing a liquid suspension comprises homogenizing one or more of the excipients by feeding them into a vessel provided by an agitation facility. contain. Elemental sulfur and at least one anthranilic diamide pesticide were added to the homogenized mixture and stirred continuously for about 5-10 minutes until the entire mixture was homogeneous. The resulting suspension is subsequently passed through a wet mill to obtain the desired particle size ranging from 0.1 to 50 microns. The required amount of structuring agent is then added to the resulting suspension under continuous homogenization. However, one skilled in the art will recognize that the process or process parameters can be modified or altered or varied to obtain a liquid suspension composition without departing from the scope of the present invention.

According to one embodiment, the composition of the present invention is at least one of a pest control composition, a crop protection composition, a fertilization mediator composition, a crop enhancement composition, a yield enhancement composition.

According to one embodiment, the present invention is a method of protecting crops, controlling pests, improving crop health and growth, promoting yield, strengthening plants, and increasing crop protection, comprising: , seeds, crops, plants, plant propagation material, loci, portions thereof, or surrounding soil with an effective amount of a pest control composition, wherein the composition comprises elemental sulfur present in the range 40% w/w to 95% w/w of the total composition, at least one anthranilic diamide present in the range 0.1% w/w to 3% w/w of the total composition It also relates to said method comprising the insecticide in the form of water-dispersible granules or spheroidized granules, liquid suspension.

The composition is applied via various methods. Methods of application to the soil include any suitable method that ensures that the composition permeates the soil, such as nursery tray application, furrow application, soil irrigation, soil infusion, drip irrigation, sprinkler irrigation. , seed treatment, seed painting, and other such methods. The composition is also applied in the form of a foliar spray.

The rate of application or dosage of the composition will depend on the type of use, the type of crop, or the specific active ingredient in the composition, but will provide the desired effect (crop protection, yield, etc.). Such that the pesticidal active ingredient is in an effective amount.

A. Preparative Examples The following examples illustrate the basic methodology and versatility of the compositions of the present invention. Note that the invention is not limited to these examples.

I. Water-dispersible granular composition of elemental sulfur and anthranilic diamide insecticide

<Example 1: Water-dispersible granular composition of 75% elemental sulfur and 0.6% cyantraniliprole>
A water dispersible granule composition was prepared by adding 75 parts elemental sulfur, 0.6 parts cyantraniliprole, 6 parts naphthalene sulfonate condensate, 15 parts bentonite, and 3.4 parts lignin sulfonate. It was prepared by blending to obtain a blend. The resulting blend was mixed with water in a suitable mixer and ground to form a slurry or wet blend.

The resulting wet-milled slurry was spray dried at an inlet temperature of less than 175°C and an outlet temperature of less than 90°C to obtain a granular powder. The composition had a particle size of approximately 10 microns and a granule size of 2 mm. The composition has a dispersibility of 90%, a suspendability of 85%, a wet sieve retention value of 0.1%, and a wettability of better than 60 seconds. The composition further exhibited 85% dispersibility and about 81% suspendability under accelerated storage conditions.

<Example 2: Water-dispersible granular composition of 75% elemental sulfur and 0.5% tetraniliprole>
Granules are made by blending 75 parts elemental sulfur, 0.5 parts tetraniliprole, 8 parts naphthalenesulfonic acid, 5 parts maltodextrin, 6.5 parts kaolin, and 5 parts silica. Prepared according to the process described in Example 1. The composition had a particle size of approximately 13 microns and a granule size of 1.5 mm. The composition has a dispersibility of 85%, a suspendability of 79%, a wet sieve retention value of 0.1%, and a wettability of better than 40 seconds. The composition further exhibited 80% dispersibility and about 74% suspendability under accelerated storage conditions.

<Example 3: Water-dispersible granular composition of 80% elemental sulfur and 0.33% chlorantraniliprole>
The granules are made by blending 80 parts elemental sulfur, 0.33 parts chlorantraniliprole, 10 parts lignin sulfonate, 6 parts polyvinylpyrrolidone, 3.67 parts modified silica. Prepared according to the process described in Example 1. The composition had a particle size of approximately 18 microns and a granule size of 1.5 mm. The composition has a dispersibility of 79%, a suspendability of 76%, a wet sieve retention value of 0.3%, and a wettability of less than 10 seconds. The composition further exhibited a dispersibility of 70% and a suspendability of about 74% under accelerated storage conditions.

<Example 4: Water-dispersible granular composition of 90% elemental sulfur and 1.5% tetrachlorane traniliprole>
The granules are blended with 90 parts elemental sulfur, 1.5 parts tetrachlorane traniliprole, 4 parts polycarboxylate, 2.5 parts modified starch, and 2 parts phenolsulfonic acid condensate. Prepared according to the process described in Example 1 by The composition had a particle size of approximately 11 microns and a granule size of 1.0 mm. The composition has a dispersibility of 88%, a suspendability of 83%, a wet sieve retention value of 0.04%, and a wettability of better than 40 seconds. The composition further exhibited a dispersibility of 82% and a suspendability of about 77% under accelerated storage conditions.

<Example 5: Water-dispersible granular composition of 60% elemental sulfur and 2.5% cyclaniliprole>
The granules were prepared in Example 1 by blending 60 parts elemental sulfur, 2.5 parts cyclaniliprole, 4 parts EO/PO copolymer, 10 parts sodium dodecyl sulfate, and 23.5 parts china clay. Prepared according to the process described in The composition had a particle size of approximately 21 microns and a granule size of 2.0 mm. The composition has a dispersibility of 60%, a suspendability of 55%, a wet sieve retention value of 0.4%, and a wettability of less than 55 seconds. The composition further exhibited a dispersibility of 58% and a suspendability of about 50% under accelerated storage conditions.

Example 6: Extruded Granular Composition of 40% Elemental Sulfur and 2.9% Cyclaniliprole
Extruded granules were mixed with 40 parts elemental sulfur, 2.9 parts cycalniliprole, 20.1 parts sodium phenylsulfonate, 16 parts modified starch, 11 parts sodium salts of fatty acids, and Prepared by mixing 10 parts china clay. The resulting blend is dry milled to obtain the desired particle size blend. Water is added to the blend to form a dough and extruded to obtain extruded granules. The composition had a particle size of approximately 25 microns and a granule size of 5.5 mm. The composition has a dispersibility of 85%, a suspendability of 75%, a wet sieve retention value of 0.3%, and a wettability of less than 60 seconds. The composition further exhibited a dispersibility of 79% and a suspendability of about 70% under accelerated storage conditions.

Example 7: Extruded Granular Composition of 75% Elemental Sulfur and 1.5% Tetrachlorantaniliprole
Extruded granules were mixed with 75 parts elemental sulfur, 1.5 parts tetrachlorantaniliprole, 9 parts polaxomer, 6 parts sodium carbonate, 3.5 parts bentonite, and 5 parts of sorbitol. The composition had a particle size of approximately 13 microns and a granule size of 4 mm. The composition has a dispersibility of 55%, a suspendability of 40%, a wet sieve retention value of 0.5%, and a wettability of less than 30 seconds. The composition further exhibited a dispersibility of 46% and a suspendability of about 36% under accelerated storage conditions.

<Example 8: Spheroidized granular composition of 90% elemental sulfur and 0.48% chlorantraniliprole>
The composition is blended with 90 parts of elemental sulfur and 0.48 parts of chlorantraniliprole, 6.52 parts of naphthalene sulfonate condensate, and 3 parts of sodium lignosulfonate to obtain a blend Prepared by The resulting blend was milled to obtain a powder with a particle size of less than 50 microns. The powder was mixed with water in a suitable mixer to form a slurry. The resulting slurry was wet ground in suitable wet grinding equipment. The resulting wet-milled slurry was spray dried at an inlet temperature of less than 180°C and an outlet temperature of less than 85°C to obtain a granulated powder with less moisture. The spray-dried powder thus obtained was agglomerated in a fluid bed dryer followed by a pin agglomerator and a dish granulator. The pan granulator speed was maintained at approximately 35 rpm to obtain an agricultural granule composition. Water was incorporated at the time of flocculation. The resulting granules were then further dried in a post-fluid bed dryer at a temperature around 70°C to remove residual moisture. The sample had a granule size of 3.5 mm, a particle size of 25 microns. The granule composition had a wettability of less than 100 seconds, a hardness of 45N, a suspendability of 53%, and a dispersibility of 50%. The composition further exhibited a dispersibility of 45% and a suspendability of about 50% under accelerated storage conditions.

<Example 9: Spheroidized granules of 75% elemental sulfur and 0.25% cyclaniliprole>
The composition of Example 9 was prepared by blending 75 parts elemental sulfur, 0.25 parts cyclaniliprole, 10 parts lignosulfonate, 3.75 parts kaolin, and 11 parts maltodextrin. Prepared according to The composition had a granule size of 4.5 mm, a particle size of 38 microns, a hardness of 60N, a suspendability of 50% and a dispersibility of 38%. The composition further exhibited 35% dispersibility and 45% suspendability under accelerated storage conditions.

<Example 10: Spheroidized granules of 60% elemental sulfur and 0.4% tetraniliprole>
The composition was prepared by admixing 60 parts elemental sulfur, 0.4 parts tetraniliprole, 15 parts sodium naphthalenesulfonate condensate, 3.6 parts silica and 11 parts starch, and 10 parts polyvinyl alcohol. , prepared according to Example 9. The composition had a granule size of 5 mm, a particle size of 40 microns, a hardness of 55 N, a suspendability of 50% and a dispersibility of 45%. The composition further exhibited 41% dispersibility and 46% suspendability under accelerated storage conditions.

<Example 11: Spheroidized granules of 55% elemental sulfur and 1.5% tetrachlorane traniliprole>
Example 9 by blending 75 parts elemental sulfur, 1.5 parts tetrachlorane traniliprole, 19 parts sodium salt of lignosulfonate, 2.5 parts starch, and 2 parts polyvinylpyrrolidone composition according to The composition had a granule size of 3.0 mm, a particle size of 20 microns, a hardness of 38N, a suspendability of 55% and a dispersibility of 45. The composition further exhibited 41% dispersibility and 51% suspendability under accelerated storage conditions.

II. Liquid suspension compositions of amino acids, their salts, polymers, or derivatives, or mixtures thereof and elemental sulfur

<Example 12: Liquid suspension composition of 50% elemental sulfur and 0.33% tetraniliprole>
The liquid suspension composition was prepared by adding 50 parts elemental sulfur, 0.33 parts tetraniliprole, 12 parts naphthalene sulfonate condensate, 4.66 parts tristyrylphenol ethoxylate phosphate, 5.01 parts of ethylene glycol, 24 parts of water and homogenizing by feeding them into a vessel provided with stirring equipment until the whole mixture is homogeneous. The resulting suspension is then passed through a wet mill to obtain a 7 micron particle size suspension. Then 4 parts guar gum (3%) was added under continuous homogenization to obtain a suspension concentrate. The composition has a suspendability of about 95%, a dispersibility of 97%, a viscosity of about 550 cps, a pourability of less than 1.5%, and a wet sieve retention value of less than 0.1%. The composition has a suspendability of about 89%, a dispersibility of 94%, and a viscosity of about 600 cps under accelerated storage conditions.

<Example 13: Liquid suspension composition of 59% elemental sulfur and 1% tetrachlorane traniliprole>
A liquid suspension composition was prepared by mixing 59 parts sulfur, 1 part tetrachloranetraniliprole, 7 parts sodium dodecylbenzenesulfonate, 4 parts glyceryl monolaurate, 6 parts polyvinylpyrrolidone, 21 parts water, and Prepare according to Example 12 using 2 parts Rhamzan gum (3%). The composition has a particle size of 10 microns, a suspendability of about 87%, a dispersibility of 90%, a viscosity of about 800 cps, an injectability of less than 1.7%, and a wet sieve retention value of less than 0.1%. have. The composition has a suspendability of about 80%, a dispersibility of 85%, and a viscosity of about 850 cps under accelerated storage conditions.

<Example 14: Liquid suspension composition of 40% elemental sulfur and 2.5% cyclaniliprole>
A liquid suspension composition was prepared by mixing 40 parts sulfur, 2.5 parts cyclaniliprole, 6 parts monoethylene glycol, 16 parts ligninsulfonate and 10.5 parts phenolsulfonic acid, 25 parts water. Prepared according to Example 12 using The composition has a particle size of 23 microns, a suspendability of about 75%, a dispersibility of 70%, a viscosity of about 1500 cps, a pourability of less than 2.5%, and a wet sieve retention value of less than 0.5%. have. The composition has a suspendability of about 69%, a dispersibility of 64%, and a viscosity of about 1550 cps under accelerated storage conditions.

B. Field research <Field test 1: Study of the effects of elemental sulfur and anthranilic diamide pesticides for controlling insect pests in paddy rice>
A field trial was carried out to study the effect of the combination of elemental sulfur and anthranilic diamide insecticides on insect pests in rice crops. The study was designed during the wet season (ie, June-September) in a randomized block design (RBD) with eight treatments, including an untreated control, with four replicates. Formulated doses of test product samples (sulphur and anthranilic diamide insecticides, alone and in combination) were applied as soil applications 20 days after transplanting rice seedlings in the test plots. Paddy rice crops in the test field were grown with good farming practices.

[Experiment details]
a) Study location: Kaithal, Haryana
b) Crops: paddy rice (variety Pusa1121)
c) Experimental season: rainy season d) Study design: RBD
e) Iterations: 3
f) Treatment: 8
g) Area size: 6m x 10m
h) Date of sowing: 21.06.2019 i) Date of application: 09.07.2019 j) Method of application: soil application k) Date of harvest: 26.09.2019

Observations for stem borer damage caused by Scirpophaga incertulas and leaf folder damage caused by Cnaphalo crosismedinalis were recorded from each plot 50 days after rice planting and percent control was calculated using the following formula: calculated using
Control (%) = [(damage in control area - damage in treated area)/damage in control area] x 100
Mean data for the controls against the pitted borer and the clump borer, along with the grain yield, were recorded at harvest and shown in Table 1.

Compositions comprising elemental sulfur and at least one anthranilic diamide pesticide in the form of liquid suspensions or water-dispersible granules prepared according to embodiments of the present invention are synergistic in nature and It can be observed from the data shown in Table 1 that it is effective in controlling the pitted borer. Synergistic compositions prepared according to embodiments of the present invention also have improved crop yields compared to individual applications of sulfur, anthranilic diamide pesticides, and untreated plots. "Synergy" is defined in Weeds, 1967, 15, p. In an article titled "Calculation of the synergistic and antagonistic responses of herbicide combinations", published in 20-22, Colby S. R. as defined by The expected action for a given combination of two active components can be calculated as follows.
E=X+Y-(XY/100)
During the ceremony,
E=% effect expected by a mixture of the two products X and Y at a defined dose.
X=% effect observed with product A.
Y=% effect observed with product B;
The synergy factor (SF) is calculated by Abbott's formula (equation (2) (Abbott, 1925)).
SF=observed effect/predicted effect, where SF>1 is a synergistic response, SF<1 is an antagonizing response, and SF=1 is an additive response.

A synergistic effect of the combination can be inferred if the percentage yield effect (E) observed for the combination is greater than the expected percentage. A mere additive effect can be inferred if the percentage yield effect observed for the combination is equal to the expected percentage, and if the percentage yield effect observed for the combination is lower than the expected percentage Antagonist effects of combinations can be inferred.

For example, treatment T1 (4000 g/acre, 75% sulfur + 0.5% tetraniliprole, WG, according to an embodiment of the invention), T2 (6000 ml/acre, 50% sulfur + Tetraniliprole 0.33%, SC) compared to T10 (80% sulfur, WG) and T7 (at 100 ml/acre, tetraniliprole 20%, SC) applied at the same dosage, treatment T1 and T2 gave 78.3% and 76.7% control, respectively, and treatments T7 and T10 gave 68.3% and 15% control against the pitted moth. The percent yield increase compared to untreated plots was about 38.8% and 36.11% for T1 and T2, respectively, while it was about 11.1% and 22.2% for T7 and T10, respectively. As shown in Table 1, the pest control and efficacy data show that the combination of sulfur and tetraniliprole in the form of water-dispersible granules or liquid suspensions is synergistic in nature.

Similarly, treatments T3 (4000 g/acre, according to an embodiment of the invention, 75% sulfur + 0.6% cyantraniliprole, WG), T4 (6000 ml/acre, according to an embodiment of the invention, 50% sulfur % + cyantraniliprole 0.4%, SC) was compared to T8 (10% cyantraniliprole, OD at 240 ml/acre) and T10 (80% sulfur, WG) applied at the same dosage. Note that treatments T3 and T4 gave 70% and 56.3% control, respectively, against the Columbine borer and approximately 82% and 85.3% control against the pitted borer. The expected control for the combination of sulfur and cyantraniliprole was approximately 76.2% against the pitted borer and 62.4% against the dillworm. Percent yield increases compared to untreated plots were about 35% and 33.3% for treatments T3 and T4, respectively, while T8 and T10 were about 8.3% and 22.2%, respectively. Similar trends were observed with individual application of actives and other treatments compared to untreated areas. Therefore, the combination of elemental sulfur and anthranilic diamide pesticides in the form of WDG and SC according to embodiments of the present invention is synergistic in nature and provides more protection against pests compared to the application of the actives individually. Provides good control and higher yields.

<Field test 2: Investigation of the effect of elemental sulfur and anthranilic diamide insecticides on the moth in paddy rice>
A trial was conducted on paddy rice in Kaithal District, Haryana State, India to evaluate the effectiveness of elemental sulfur and anthranilic diamide insecticide spheroidized granules according to embodiments of the present invention. Treatments were performed according to a randomized block design to keep all farm practices uniform for all treatments. Treatment was carried out by spraying the composition 25-30 days after transplanting rice. Efficacy was evaluated 50 days and 90 days after rice transplantation. To avoid intermixing of treatments, a temporary embankment boundary approximately 20-30 cm thick was provided all around the area treated with particulate pesticides. The treatments applied are indicated in the table below.

Paddy rice crops in the test field were grown with good farming practices.

[Experiment details]
a) Study location: Kaithal, Haryana
b) Crops: paddy rice (variety Pusa1121)
c) Experimental season: rainy season d) Study design: RBD
e) Iterations: 3
f) Treatment: 8
g) Area size: 6m x 10m
h) Date of sowing: June 19, 2019 i) Date of application: July 7, 2019 j) Method of application: soil application k) Date of harvest: September 23, 2019

Compositions comprising elemental sulfur in the form of granules prepared according to embodiments of the present invention and at least one anthranilic diamide pesticide are synergistic in nature and effective in controlling the moth in rice. can be observed from the data presented in Table 2. The percentage of dead core and white ears was found to be lowest in areas treated with treatments T1 and T2, respectively, compared to the other treatments, demonstrating that the compositions of the present invention are effective in reducing damage caused by the moth. show that it is excellent in protecting paddy rice crops against For example, treatment T2 had 4.6% dead core 50 days after transplanting, while treatments T4 and T5 showed approximately 14.2% and 7.9% dead core, respectively. Similarly, the percentage of white spikes with treatments T2, T4, and T5 was approximately 1.7%, 23.5%, and 26%, respectively. Therefore, the combination of elemental sulfur and anthranilic diamide pesticides in the form of spheroidized granules according to embodiments of the present invention is synergistic in nature, providing more protection against pests compared to the application of the actives individually. It can be noted that it provides good control and higher yields.

In addition, the inventors of the present invention also tested combinations of elemental sulfur, at least one anthranilic diamide insecticide on certain crops such as peanuts, eggplants. It has been observed that the combinations of the invention provide better control against pests compared to the application of the individual actives. Further, such combinations help improve crop characteristics such as yield, straw weight, plant height, and the like. Thus, the compositions of the present invention were observed to be accelerated, effective and perform well in the field.

A carefully selected combination of properties (i.e., specific granule sizes that disperse into specific size ranges of particles with good suspendability, dispersibility, and adequate hardness) are applied to the soil. The inventors have determined that, in this case, it results in a composition that provides not only an immediate release of the active substance, but also a sustained and sustained release during the entire plant life cycle. Therefore, it provides effective crop protection and nutrient solution to crops. The compositions of the present invention also provide immediate release of actives that strengthen and protect crops against pest attack when applied to the foliage or soil.

From the foregoing, it will be noted that numerous modifications and variations may be made without departing from the true spirit and scope of the novel concept of the present invention. It should be understood that no limitation with respect to the particular embodiments illustrated is intended or should be implied.

Claims (21)

A granular pest control composition comprising:
elemental sulfur in the range of 40% w/w to 95% w/w of the total composition;
at least one anthranilic diamide insecticide present in the range of 0.1% w/w to 3% w/w of the total composition;
at least one agrochemical excipient;
wherein the composition is in the form of water-dispersible granules or spheroidized granules;
the size of the granules ranges from 0.1 mm to 6 mm;
A composition wherein said granules are dispersed into particles ranging in size from 0.1 microns to 50 microns. A liquid suspension pest control composition comprising:
elemental sulfur in the range of 40% w/w to 95% w/w of the total composition;
at least one anthranilic diamide insecticide ranging from 0.1% w/w to 3% w/w of the total composition;
at least one agrochemical excipient;
A composition wherein the particle size of said composition ranges from 0.1 microns to 50 microns. 3. The at least one anthranilic diamide insecticide according to claim 1 or 2, selected from cyantraniliprole and tetraniliprole and cyclaniliprole and tetrachlorantraniliprole and chlorantraniliprole. composition. The composition of claim 1, wherein said granules are dispersed into particles ranging in size from 0.1 microns to 20 microns. The composition according to claim 1, wherein said water-dispersible granules have a granule size ranging from 0.1 mm to 2.5 mm. Said at least one agrochemically acceptable excipient is at least one surface-active substance, binding substance or filler substance or carrier or diluent substance, disintegrating agent, buffering substance or pH adjusting substance or neutralizing agent, antifoaming agent 2. The method of claim 1, comprising agents, anti-settling agents, anti-caking agents, penetrants, sticking agents, UV-absorbing substances, UV-scattering agents, tackifying substances, pigments, coloring substances, stabilizing substances, and mixtures thereof. composition. The at least one agrochemically acceptable excipient is at least one structuring agent, surfactant, humectant, solvent, water-miscible solvent, spreading agent, suspending agent or suspending aid. Alternatively, an anti-settling agent, penetrant, sticking agent, drift reducing agent, ultraviolet absorbing agent, ultraviolet scattering agent, antiseptic agent, stabilizing agent, buffering agent or pH adjusting agent or neutralizing agent, antifreeze agent or freezing point depressing agent, 3. The composition of claim 2, comprising an antifoaming agent. 8. A composition according to claim 6 or 7, wherein said surface-active substance comprises at least one of an emulsifying substance, a wetting agent and a dispersing agent. 8. The composition of Claim 7, wherein the structurant comprises at least one of a thickening agent, a viscosity modifier, a tackifying agent, a suspension aid, a rheology modifier, and an anti-settling agent. 2. The composition of claim 1, wherein said composition has a wettability of less than 2 minutes. 2. The composition of claim 1, wherein said spheroidized granules have a hardness of less than 100 Newtons. 3. The composition of claim 2, wherein said composition has a viscosity of 10cps to 3000cps. 3. The composition of claim 2, wherein said composition has a residual injectability of less than 5%. 3. The composition of claim 1 or 2, wherein the composition has a suspensibility of at least 30%. 3. The composition of claim 1 or 2, wherein the composition has a dispersibility of at least 30%. 3. The composition of claim 1 or 2, wherein the suspendability or dispersibility of said composition is greater than 30% under accelerated storage conditions. 3. The wet sieve retention value for the water dispersible granule composition or liquid suspension composition on a 75 micron sieve is less than 0.5%, preferably less than 0.2%, according to claim 1 or 2. composition. A process for preparing the water dispersible granular pest control composition of claim 1, comprising:
a. grinding an admixture of elemental sulfur and at least one anthranilic diamide pesticide with at least one agrochemical excipient to obtain a slurry or wet mixture;
b. drying said wet mixture to obtain said water-dispersible granular composition, said granules of said composition comprising granules in the size range of 0.1 to 2.5 mm;
process, including A process for preparing the spheroidized granular pesticide composition of claim 1, comprising:
c. grinding an admixture of elemental sulfur and at least one anthranilic diamide pesticide with at least one agrochemical excipient to obtain a slurry or wet mixture;
d. drying said wet mixture to obtain said water-dispersible granular composition, said granules of said composition consisting of granules in the size range of 0.1 to 2.5 mm;
e. adding water to the dry powder and kneading said mixture to obtain a dough or paste, which is then extruded through an extruder to obtain extruded granules in the size range of 0.1 mm to 6 mm; or agglomerating said wet mixture or said dry powder obtained in (b) in an agglomerator to obtain a granular composition in the size range of 0.1 mm to 6 mm;
process, including A process for preparing the liquid suspension pest control composition of claim 2, comprising:
homogenizing a mixture of elemental sulfur, at least one anthranilic diamide pesticide, and at least one agrochemically acceptable excipient to obtain a suspension;
wet milling the resulting suspension to provide a composition with a particle size range of 0.1 microns to 50 microns;
process, including 3. A composition according to claim 1 or 2, which is at least one of a pest control or crop protection composition, a crop enhancer composition, a fertilization agent or nutrient composition, a yield enhancer composition.